ID   SCX2_HOTTA              Reviewed;          24 AA.
AC   P45668;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Neurotoxin-2;
DE   AltName: Full=BT-II;
DE   AltName: Full=Neurotoxin II;
DE   Flags: Fragment;
OS   Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34647;
RN   [1]
RP   PROTEIN SEQUENCE, AND TOXIC DOSE.
RC   TISSUE=Venom;
RX   PubMed=8016854; DOI=10.1016/0041-0101(94)90085-x;
RA   Lala K., Narayanan P.;
RT   "Purification, N-terminal sequence and structural characterization of a
RT   toxic protein from the Indian scorpion venom Buthus tamulus.";
RL   Toxicon 32:325-338(1994).
CC   -!- FUNCTION: Binds to sodium channels (Nav) and inhibits the inactivation
CC       of the activated channels, thereby blocking neuronal transmission. This
CC       toxin is active against mammals.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is 2.25 mg/kg in mice by subcutaneous injection.
CC       {ECO:0000269|PubMed:8016854}.
CC   -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC       Sodium channel inhibitor family. Alpha subfamily. {ECO:0000305}.
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DR   PIR; A53357; A53357.
DR   AlphaFoldDB; P45668; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR   PROSITE; PS51863; LCN_CSAB; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>24
FT                   /note="Neurotoxin-2"
FT                   /id="PRO_0000066758"
FT   DOMAIN          1..>24
FT                   /note="LCN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   NON_TER         24
SQ   SEQUENCE   24 AA;  2686 MW;  DA1990C8FF8E2769 CRC64;
     EDGYLLNRDT GCKVSCGTCR YCND