SCX2_TITME
ID SCX2_TITME Reviewed; 65 AA.
AC P0DQU7;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 1.
DT 03-AUG-2022, entry version 2.
DE RecName: Full=Sodium channel toxin 2;
OS Tityus metuendus (Scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX NCBI_TaxID=2203750;
RN [1]
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=29337221; DOI=10.1016/j.toxicon.2018.01.006;
RA Batista C.V.F., Martins J.G., Restano-Cassulini R., Coronas F.I.V.,
RA Zamudio F.Z., Procopio R., Possani L.D.;
RT "Venom characterization of the Amazonian scorpion Tityus metuendus.";
RL Toxicon 143:51-58(2018).
CC -!- FUNCTION: Alpha toxins bind voltage-independently at site-3 of sodium
CC channels (Nav) and inhibit the inactivation of the activated channels,
CC thereby blocking neuronal transmission. {ECO:0000250|UniProtKB:P60212}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29337221}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:29337221}.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC {ECO:0000250|UniProtKB:P60212}.
CC -!- MASS SPECTROMETRY: Mass=7318.00; Method=Electrospray; Note=Average
CC mass.; Evidence={ECO:0000269|PubMed:29337221};
CC -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC Sodium channel inhibitor family. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.30.30.10; -; 1.
DR InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR InterPro; IPR003614; Scorpion_toxin-like.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR InterPro; IPR018218; Scorpion_toxinL.
DR InterPro; IPR002061; Scorpion_toxinL/defensin.
DR Pfam; PF00537; Toxin_3; 1.
DR PRINTS; PR00285; SCORPNTOXIN.
DR SMART; SM00505; Knot1; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
DR PROSITE; PS51863; LCN_CSAB; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond; Secreted.
FT CHAIN 1..65
FT /note="Sodium channel toxin 2"
FT /id="PRO_0000455695"
FT DOMAIN 2..64
FT /note="LCN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT MOD_RES 65
FT /note="Lysine amide"
FT /evidence="ECO:0000250|UniProtKB:P60212"
FT DISULFID 12..63
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT DISULFID 16..38
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT DISULFID 24..44
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT DISULFID 28..46
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
SQ SEQUENCE 65 AA; 7327 MW; F85BB964FA4B2111 CRC64;
NKDGYLMEGD GCKMGCLTRK ASYCVDQCKE VGGKDGYCYA WLSCYCYNMP DSVEIWDSKN
NKCGK