ID   BETI_VIBA3              Reviewed;         200 AA.
AC   B7VQ27;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI {ECO:0000255|HAMAP-Rule:MF_00768}; OrderedLocusNames=VS_II0056;
OS   Vibrio atlanticus (strain LGP32) (Vibrio splendidus (strain Mel32)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=575788;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LGP32;
RA   Mazel D., Le Roux F.;
RT   "Vibrio splendidus str. LGP32 complete genome.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC       glycine betaine. It represses transcription of the choline transporter
CC       BetT and the genes of BetAB involved in the synthesis of glycine
CC       betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC       choline pathway [regulation].
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DR   EMBL; FM954973; CAV25275.1; -; Genomic_DNA.
DR   RefSeq; WP_012600068.1; NC_011744.2.
DR   AlphaFoldDB; B7VQ27; -.
DR   SMR; B7VQ27; -.
DR   STRING; 575788.VS_II0056; -.
DR   EnsemblBacteria; CAV25275; CAV25275; VS_II0056.
DR   KEGG; vsp:VS_II0056; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_15_4_6; -.
DR   OMA; WLAFYAE; -.
DR   OrthoDB; 1745184at2; -.
DR   UniPathway; UPA00529; -.
DR   Proteomes; UP000009100; Chromosome 2.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..200
FT                   /note="HTH-type transcriptional regulator BetI"
FT                   /id="PRO_1000148447"
FT   DOMAIN          8..68
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT   DNA_BIND        31..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ   SEQUENCE   200 AA;  22472 MW;  4CDCA7BC80CE16CB CRC64;
     MPKVGMPDIR KPQLVQATMT VIDRVGLHAA SIALISKEAG VSTGIINHYF GGKHGLLEET
     MREILRQLSN TVTTELKALP ADAHQQRINA IINGNFEGYQ AENKVSKTWL AFWSYSMHDA
     QLKRLQRVNE KRLISHLLIE LKSIFQPDQA ELIAHGIASL IDGIWLRGTL NPEGINADKA
     RAIINDYLDK QLTFYSCQRD