ID   SCX38_CENMA             Reviewed;          19 AA.
AC   P0DTB8;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   22-APR-2020, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=Toxin Cm38 {ECO:0000303|PubMed:25633390};
DE   Flags: Fragment;
OS   Centruroides margaritatus (Central American bark Scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Centruroides.
OX   NCBI_TaxID=29018;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=25633390; DOI=10.2174/092986652202150128143048;
RA   Duenas-Cuellar R.A., Kushmerick C., Naves L.A., Batista I.F.,
RA   Guerrero-Vargas J.A., Pires O.R. Jr., Fontes W., Castro M.S.;
RT   "Cm38: a new antimicrobial peptide active against Klebsiella pneumoniae is
RT   homologous to Cn11.";
RL   Protein Pept. Lett. 22:164-172(2015).
CC   -!- FUNCTION: May block sodium channels (Nav) found (By similarity).
CC       Reversibly modifies the firing of DRG neurons by causing membrane
CC       depolarization and increasing the number of action potentials
CC       (PubMed:25633390). Shows antimicrobial activity against the Gram-
CC       negative bacteria K.pneumoniae (MIC=64 uM), and only a very weak
CC       activity against S.aureus (PubMed:25633390). Does not show hemolytic
CC       activity (PubMed:25633390). {ECO:0000250|UniProtKB:P58296,
CC       ECO:0000269|PubMed:25633390}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25633390}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:25633390}.
CC   -!- MASS SPECTROMETRY: Mass=6800.31; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:25633390};
CC   -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC       Sodium channel inhibitor family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=02518";
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DR   AlphaFoldDB; P0DTB8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR   InterPro; IPR002061; Scorpion_toxinL/defensin.
DR   Pfam; PF00537; Toxin_3; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>19
FT                   /note="Toxin Cm38"
FT                   /id="PRO_0000449319"
FT   DISULFID        12..?
FT                   /evidence="ECO:0000305"
FT   DISULFID        16..?
FT                   /evidence="ECO:0000305"
FT   NON_TER         19
SQ   SEQUENCE   19 AA;  2149 MW;  210AC16CDB0DA014 CRC64;
     ARDGYIVDEK GCKFACFIN