ID   BETI_VIBVY              Reviewed;         198 AA.
AC   Q7MF14;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI {ECO:0000255|HAMAP-Rule:MF_00768}; OrderedLocusNames=VVA0506;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC       glycine betaine. It represses transcription of the choline transporter
CC       BetT and the genes of BetAB involved in the synthesis of glycine
CC       betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC       choline pathway [regulation].
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DR   EMBL; BA000038; BAC96532.1; -; Genomic_DNA.
DR   RefSeq; WP_011151877.1; NC_005140.1.
DR   AlphaFoldDB; Q7MF14; -.
DR   SMR; Q7MF14; -.
DR   STRING; 672.VV93_v1c35130; -.
DR   EnsemblBacteria; BAC96532; BAC96532; BAC96532.
DR   KEGG; vvy:VVA0506; -.
DR   PATRIC; fig|196600.6.peg.3706; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_15_4_6; -.
DR   OMA; WLAFYAE; -.
DR   OrthoDB; 1745184at2; -.
DR   UniPathway; UPA00529; -.
DR   Proteomes; UP000002675; Chromosome II.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..198
FT                   /note="HTH-type transcriptional regulator BetI"
FT                   /id="PRO_0000070590"
FT   DOMAIN          8..68
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT   DNA_BIND        31..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ   SEQUENCE   198 AA;  22277 MW;  BD8C7BC0CB8FFFAD CRC64;
     MPKVGMPKIR RPQLVSATMT VIDRVGLHGA SVSLISQEAG VSSGIINHYF GGKHGLLEET
     MRDILRQLSC DATKRLNSLP KQAHMQRINA ILDANFVGFQ SESKVIKTWL AFWSYSMHDE
     ALKRLQRVNE KRLLSHLKRE LKALMSKEQA DIVAQGIAAL IDGIWLRGAL NPEGINANKA
     RIIINDYLEK QLTFYSQQ