ABDA_CULQU
ID ABDA_CULQU Reviewed; 216 AA.
AC B0W1V2;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Homeobox protein abdominal-A homolog;
GN Name=abd-A {ECO:0000250|UniProtKB:P29555}; ORFNames=CPIJ001016;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000312|EMBL:EDS27388.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000312|EMBL:EDS27388.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000255}.
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DR EMBL; DS231824; EDS27388.1; -; Genomic_DNA.
DR RefSeq; XP_001842686.1; XM_001842634.1.
DR AlphaFoldDB; B0W1V2; -.
DR SMR; B0W1V2; -.
DR STRING; 7176.CPIJ001016-PA; -.
DR KEGG; cqu:CpipJ_CPIJ001016; -.
DR VEuPathDB; VectorBase:CPIJ001016; -.
DR VEuPathDB; VectorBase:CQUJHB003948; -.
DR eggNOG; KOG0489; Eukaryota.
DR HOGENOM; CLU_1278737_0_0_1; -.
DR InParanoid; B0W1V2; -.
DR OMA; NCLHTRS; -.
DR OrthoDB; 1128667at2759; -.
DR PhylomeDB; B0W1V2; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR022132; Abdominal-A.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF12407; Abdominal-A; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..216
FT /note="Homeobox protein abdominal-A homolog"
FT /id="PRO_0000343524"
FT DNA_BIND 43..102
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 112..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 216 AA; 24606 MW; 9C906C3D142559A7 CRC64;
MCDIVRCRRS QLIRGHVLAR LCHGIASPLL GRLRPRRPNG CPRRRGRQTY TRFQTLELEK
EFHFNHYLTR RRRIEIAHAL CLTERQIKIW FQNRRMKLKK ELRAVKEINE QARREREEQD
KMKNDSLKSA QQHHQSQKQQ QQEHTVVGSQ QTSGGGGGGS TSLGSHLHHP SIVAQNDLKL
GLGSMGVGVG GNLSMMGGLD NKTNQDILKA VSNVHS