ID   SCXE_TITPA              Reviewed;          20 AA.
AC   P0DW31;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Toxin TpF21-Cocle {ECO:0000303|PubMed:29196122};
DE   Flags: Fragment;
OS   Tityus pachyurus (Colombian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=288781;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   STRAIN=Cocle area; TISSUE=Venom;
RX   PubMed=29196122; DOI=10.1016/j.toxicon.2017.11.013;
RA   Salazar M.H., Arenas I., Corrales-Garcia L.L., Miranda R., Velez S.,
RA   Sanchez J., Mendoza K., Cleghorn J., Zamudio F.Z., Castillo A.,
RA   Possani L.D., Corzo G., Acosta H.;
RT   "Venoms of Centruroides and Tityus species from Panama and their main toxic
RT   fractions.";
RL   Toxicon 141:79-87(2018).
CC   -!- FUNCTION: Beta toxins bind voltage-independently at site-4 of sodium
CC       channels (Nav) and shift the voltage of activation toward more negative
CC       potentials thereby affecting sodium channel activation and promoting
CC       spontaneous and repetitive firing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29196122}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:29196122}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=7332.4; Method=Electrospray; Note=Average
CC       mass.; Evidence={ECO:0000269|PubMed:29196122};
CC   -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC       Sodium channel inhibitor family. Beta subfamily. {ECO:0000305}.
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DR   PROSITE; PS51863; LCN_CSAB; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>20
FT                   /note="Toxin TpF21-Cocle"
FT                   /evidence="ECO:0000305|PubMed:29196122"
FT                   /id="PRO_0000456229"
FT   DOMAIN          1..>20
FT                   /note="LCN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   DISULFID        11..?
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   DISULFID        15..?
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   NON_TER         20
FT                   /evidence="ECO:0000305|PubMed:29196122"
SQ   SEQUENCE   20 AA;  2225 MW;  388AFE1506FF7C7B CRC64;
     KDGYLVGNDG CKYSCNTYPK