ABDA_DROME
ID ABDA_DROME Reviewed; 590 AA.
AC P29555; Q5U161; Q9VER1;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 197.
DE RecName: Full=Homeobox protein abdominal-A;
GN Name=abd-A; ORFNames=CG10325;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ABD-A1), FUNCTION, AND SUBCELLULAR
RP LOCATION.
RX PubMed=1979297; DOI=10.1101/gad.4.9.1573;
RA Karch F., Bender W., Weiffenbach B.;
RT "abdA expression in Drosophila embryos.";
RL Genes Dev. 4:1573-1587(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING (ISOFORMS
RP ABD-A1 AND ABD-A2).
RC STRAIN=Canton-S;
RX PubMed=7667301; DOI=10.1073/pnas.92.18.8398;
RA Martin C.H., Mayeda C.A., Davis C.A., Ericsson C.L., Knafels J.D.,
RA Mathog D.R., Celniker S.E., Lewis E.B., Palazzolo M.J.;
RT "Complete sequence of the bithorax complex of Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:8398-8402(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ABD-A1).
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Required for
CC segmental identity of the second through eighth abdominal segments.
CC Once a pattern of abd-A expression is turned on in a given parasegment,
CC it remains on the more posterior parasegment, so that the complex
CC pattern of expression is built up in the successive parasegments.
CC Appears to repress expression of Ubx whenever they appear in the same
CC cell, but abd-A is repressed by Abd-B only in the eight and ninth
CC abdominal segments. {ECO:0000269|PubMed:1979297}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:1979297}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Abd-A2; Synonyms=ABD-AII, B;
CC IsoId=P29555-1; Sequence=Displayed;
CC Name=Abd-A1; Synonyms=ABD-AI, A;
CC IsoId=P29555-2; Sequence=VSP_002394;
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X54453; CAA38321.1; -; mRNA.
DR EMBL; U31961; AAA84405.1; -; Genomic_DNA.
DR EMBL; U31961; AAA84406.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF55359.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF55360.2; -; Genomic_DNA.
DR EMBL; BT016031; AAV36916.1; -; mRNA.
DR PIR; A35915; A35915.
DR RefSeq; NP_001163632.1; NM_001170161.2. [P29555-2]
DR RefSeq; NP_001247145.1; NM_001260216.2. [P29555-2]
DR RefSeq; NP_476693.1; NM_057345.5. [P29555-2]
DR RefSeq; NP_732176.1; NM_169733.5. [P29555-1]
DR AlphaFoldDB; P29555; -.
DR SMR; P29555; -.
DR BioGRID; 67081; 170.
DR DIP; DIP-17987N; -.
DR IntAct; P29555; 1.
DR STRING; 7227.FBpp0082829; -.
DR PaxDb; P29555; -.
DR DNASU; 42037; -.
DR EnsemblMetazoa; FBtr0083387; FBpp0082828; FBgn0000014. [P29555-2]
DR EnsemblMetazoa; FBtr0083388; FBpp0082829; FBgn0000014. [P29555-1]
DR EnsemblMetazoa; FBtr0300485; FBpp0289712; FBgn0000014. [P29555-2]
DR EnsemblMetazoa; FBtr0306337; FBpp0297433; FBgn0000014. [P29555-2]
DR GeneID; 42037; -.
DR KEGG; dme:Dmel_CG10325; -.
DR CTD; 42037; -.
DR FlyBase; FBgn0000014; abd-A.
DR VEuPathDB; VectorBase:FBgn0000014; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000165065; -.
DR HOGENOM; CLU_462541_0_0_1; -.
DR InParanoid; P29555; -.
DR OMA; HHINKLA; -.
DR PhylomeDB; P29555; -.
DR SignaLink; P29555; -.
DR BioGRID-ORCS; 42037; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42037; -.
DR PRO; PR:P29555; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0000014; Expressed in spermathecum and 19 other tissues.
DR ExpressionAtlas; P29555; baseline and differential.
DR Genevisible; P29555; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0005704; C:polytene chromosome band; IDA:FlyBase.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:FlyBase.
DR GO; GO:0005667; C:transcription regulator complex; IDA:CAFA.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:CAFA.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IMP:FlyBase.
DR GO; GO:0048738; P:cardiac muscle tissue development; IMP:FlyBase.
DR GO; GO:0010002; P:cardioblast differentiation; IMP:FlyBase.
DR GO; GO:0035225; P:determination of genital disc primordium; IMP:FlyBase.
DR GO; GO:0035053; P:dorsal vessel heart proper cell fate commitment; IMP:FlyBase.
DR GO; GO:0035224; P:genital disc anterior/posterior pattern formation; IEP:FlyBase.
DR GO; GO:0048806; P:genitalia development; IMP:FlyBase.
DR GO; GO:0008354; P:germ cell migration; IMP:FlyBase.
DR GO; GO:0008406; P:gonad development; TAS:FlyBase.
DR GO; GO:0007506; P:gonadal mesoderm development; IMP:FlyBase.
DR GO; GO:0007507; P:heart development; IMP:FlyBase.
DR GO; GO:0007501; P:mesodermal cell fate specification; IMP:FlyBase.
DR GO; GO:0007494; P:midgut development; TAS:FlyBase.
DR GO; GO:0042694; P:muscle cell fate specification; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IMP:FlyBase.
DR GO; GO:0014019; P:neuroblast development; IMP:FlyBase.
DR GO; GO:0007400; P:neuroblast fate determination; IMP:FlyBase.
DR GO; GO:0007438; P:oenocyte development; IMP:FlyBase.
DR GO; GO:0001742; P:oenocyte differentiation; IMP:FlyBase.
DR GO; GO:0007422; P:peripheral nervous system development; TAS:FlyBase.
DR GO; GO:0007280; P:pole cell migration; TAS:FlyBase.
DR GO; GO:0048636; P:positive regulation of muscle organ development; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:CAFA.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR022132; Abdominal-A.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF12407; Abdominal-A; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome.
FT CHAIN 1..590
FT /note="Homeobox protein abdominal-A"
FT /id="PRO_0000200249"
FT DNA_BIND 398..457
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 53..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 368..373
FT /note="Antp-type hexapeptide"
FT COMPBIAS 53..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..260
FT /note="Missing (in isoform Abd-A1)"
FT /evidence="ECO:0000303|PubMed:1979297, ECO:0000303|Ref.5"
FT /id="VSP_002394"
SQ SEQUENCE 590 AA; 62410 MW; FF080CC2D71ECA82 CRC64;
MSKFVFDSML PKYPQFQPFI SSHHLTTTPP NSSSAAVAAA LAAAAASASA SVSASSSSNN
NSSNTIAGSN TSNTNNSSSS PSSSSNNNSN LNLSGGSLSP SHLSQHLGQS PHSPVSSSSP
FQQHHPQVQQ QHLNHQQQQH LHHQQQQHHH QYSSLSAALQ LQQQQHHISK LAAAAVASHG
HAHQQLLLTP PSAGNSQAGD SSCSPSPSAS GSSSLHRSLN DNSPGSASAS ASASAASSVA
AAAAAAAAAA SSSFAIPTSK MYPYVSNHPS SHGGLSGMAG FTGLEDKSCS RYTDTVMNSY
QSMSVPASAS AQFAQFYQHA TAAASAVSAA SAGAIGVDSL GNACTQPASG VMPGAGGAGG
AGIADLPRYP WMTLTDWMGS PFERVVCGDF NGPNGCPRRR GRQTYTRFQT LELEKEFHFN
HYLTRRRRIE IAHALCLTER QIKIWFQNRR MKLKKELRAV KEINEQARRD REEQEKMKAQ
ETMKSAQQNK QVQQQQQQQQ QQQQQQQQQH QQQQQQPQDH HSIIAHNPGH LHHSVVGQND
LKLGLGMGVG VGVGGIGPGI GGGLGGNLGM MSALDKSNHD LLKAVSKVNS
