ID   SCXNF_MESEU             Reviewed;          86 AA.
AC   P86406; E4VP47; R4H619;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-JUL-2019, sequence version 2.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=Sodium channel neurotoxin MeuNaTxalpha-15 {ECO:0000312|EMBL:ADT64277.1, ECO:0000312|EMBL:ADT64278.1, ECO:0000312|EMBL:ADT64279.1, ECO:0000312|EMBL:ADT64280.1};
DE   AltName: Full=Sodium channel neurotoxin MeuNaTxalpha-6 {ECO:0000303|Ref.2};
DE   Flags: Precursor;
OS   Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34648;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Zhu S.Y., Gao B.;
RT   "Molecular characterization of sodium channel toxins from the scorpion
RT   Mesobuthus eupeus.";
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 21-86, FUNCTION, SUBCELLULAR LOCATION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom;
RA   Zhu S.Y., Gao B.;
RT   "Characterization of a sodium channel toxin from the scorpion Mesobuthus
RT   eupeus venom.";
RL   Submitted (NOV-2009) to UniProtKB.
CC   -!- FUNCTION: Inhibits sodium channels (Nav). Has antimicrobial activity.
CC       {ECO:0000269|Ref.2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.2}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.2}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=7785; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.2};
CC   -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC       Sodium channel inhibitor family. {ECO:0000255}.
CC   -!- CAUTION: Zhu and colleagues published information on another
CC       'Neurotoxin MeuNaTx-6' in 2012 (AC E7CZY9), whose sequence highly
CC       differs from the one presented here. {ECO:0000305}.
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DR   EMBL; EF445089; ABR21064.1; -; mRNA.
DR   EMBL; GU187954; ADT64277.1; -; mRNA.
DR   EMBL; GU187957; ADT64280.1; -; mRNA.
DR   EMBL; GU187955; ADT64278.1; -; mRNA.
DR   EMBL; GU187956; ADT64279.1; -; mRNA.
DR   AlphaFoldDB; P86406; -.
DR   SMR; P86406; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   CDD; cd00107; Knot1; 1.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR   InterPro; IPR003614; Scorpion_toxin-like.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR018218; Scorpion_toxinL.
DR   InterPro; IPR002061; Scorpion_toxinL/defensin.
DR   Pfam; PF00537; Toxin_3; 1.
DR   PRINTS; PR00285; SCORPNTOXIN.
DR   SMART; SM00505; Knot1; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51863; LCN_CSAB; 1.
PE   1: Evidence at protein level;
KW   Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|Ref.2"
FT   CHAIN           21..86
FT                   /note="Sodium channel neurotoxin MeuNaTxalpha-15"
FT                   /evidence="ECO:0000269|Ref.2"
FT                   /id="PRO_0000401123"
FT   DOMAIN          21..83
FT                   /note="LCN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   DISULFID        32..82
FT                   /evidence="ECO:0000250|UniProtKB:P86405"
FT   DISULFID        36..57
FT                   /evidence="ECO:0000250|UniProtKB:P86405"
FT   DISULFID        43..64
FT                   /evidence="ECO:0000250|UniProtKB:P86405"
FT   DISULFID        47..66
FT                   /evidence="ECO:0000250|UniProtKB:P86405"
SQ   SEQUENCE   86 AA;  9995 MW;  1FA58C18620A5EFB CRC64;
     MMKIIIFLIV SSLVLIGVKT DNGYLLDKYT GCKVWCVINN ESCNSECKIR RGNYGYCYFW
     KLACYCEGAP KSELWHYETN KCNGRM