ID   SCXT_PARLS              Reviewed;          14 AA.
AC   P0C5J7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   23-FEB-2022, entry version 25.
DE   RecName: Full=Insect toxin PlIT;
DE   Flags: Fragment;
OS   Parabuthus liosoma (African black tail scorpion) (Parabuthus leiosoma).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Parabuthus.
OX   NCBI_TaxID=470425;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=17618664; DOI=10.1016/j.toxicon.2007.04.020;
RA   Ochola J.B., Lwande W., Thiong'o T., Rogo L., Herrmann R., Schepers E.,
RA   Bagine R., Mungai P., Ndiege I.O.;
RT   "Identification of insect-selective and mammal-selective toxins from
RT   Parabuthus leiosoma venom.";
RL   Toxicon 50:449-456(2007).
CC   -!- FUNCTION: Binds to sodium channels (Nav) and inhibits the inactivation
CC       of the activated channels, thereby blocking neuronal transmission (By
CC       similarity). Causes prolonged contractile paralysis in C.partellus
CC       larvae. It also has significant toxic effects on B.fusca larvae but not
CC       on mice. {ECO:0000250, ECO:0000269|PubMed:17618664}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=6688.5; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17618664};
CC   -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC       Sodium channel inhibitor family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR   PROSITE; PS51863; LCN_CSAB; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>14
FT                   /note="Insect toxin PlIT"
FT                   /id="PRO_0000307897"
FT   DOMAIN          1..>14
FT                   /note="LCN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT   NON_TER         14
SQ   SEQUENCE   14 AA;  1616 MW;  9DC00D147B41734A CRC64;
     KDGYPVDNAN CKYE