SCXU_TITPA
ID SCXU_TITPA Reviewed; 39 AA.
AC P0DL25;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 1.
DT 23-FEB-2022, entry version 18.
DE RecName: Full=Putative beta-neurotoxin;
DE Flags: Fragment;
OS Tityus pachyurus (Colombian scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX NCBI_TaxID=288781;
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Venom;
RX PubMed=16309982; DOI=10.1016/j.bbapap.2005.08.010;
RA Barona J., Batista C.V.F., Zamudio F.Z., Gomez-Lagunas F., Wanke E.,
RA Otero R., Possani L.D.;
RT "Proteomic analysis of the venom and characterization of toxins specific
RT for Na+ - and K+ -channels from the Colombian scorpion Tityus pachyurus.";
RL Biochim. Biophys. Acta 1764:76-84(2006).
CC -!- FUNCTION: Beta toxins bind voltage-independently at site-4 of sodium
CC channels (Nav) and shift the voltage of activation toward more negative
CC potentials thereby affecting sodium channel activation and promoting
CC spontaneous and repetitive firing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16309982}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000269|PubMed:16309982}.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC Sodium channel inhibitor family. Beta subfamily. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR044062; LCN-type_CS_alpha_beta_dom.
DR PROSITE; PS51863; LCN_CSAB; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Neurotoxin; Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT CHAIN 1..>39
FT /note="Putative beta-neurotoxin"
FT /id="PRO_0000422257"
FT DOMAIN 3..>39
FT /note="LCN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01210"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 14..?
FT /evidence="ECO:0000250"
FT DISULFID 30..?
FT /evidence="ECO:0000250"
FT NON_TER 39
SQ SEQUENCE 39 AA; 4025 MW; 6E0E5A0E986ABAEC CRC64;
GGKEGYPLNS SNGCKSGRFA GTNSNENTEC KGXDAENGY