ID   SCX_ANDMA               Reviewed;          16 AA.
AC   P0C911;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 1.
DT   23-FEB-2022, entry version 20.
DE   RecName: Full=Alpha-toxin;
DE   Flags: Fragment;
OS   Androctonus mauritanicus mauritanicus (Scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Androctonus.
OX   NCBI_TaxID=6860;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=18243273; DOI=10.1016/j.toxicon.2007.12.012;
RA   Oukkache N., Rosso J.-P., Alami M., Ghalim N., Saile R., Hassar M.,
RA   Bougis P.E., Martin-Eauclaire M.-F.;
RT   "New analysis of the toxic compounds from the Androctonus mauretanicus
RT   mauretanicus scorpion venom.";
RL   Toxicon 51:835-852(2008).
CC   -!- FUNCTION: Alpha toxins bind voltage-independently at site-3 of sodium
CC       channels (Nav) and inhibit the inactivation of the activated channels,
CC       thereby blocking neuronal transmission. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC       Sodium channel inhibitor family. Alpha subfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>16
FT                   /note="Alpha-toxin"
FT                   /id="PRO_0000368019"
FT   NON_TER         16
SQ   SEQUENCE   16 AA;  1816 MW;  F2AFA421F02B58CA CRC64;
     GRDGYIAQPE NXVYXX