ID   SCX_CHICK               Reviewed;         187 AA.
AC   P59101;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2002, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Basic helix-loop-helix transcription factor scleraxis;
GN   Name=SCX;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11585810; DOI=10.1242/dev.128.19.3855;
RA   Schweitzer R., Chyung J.H., Murtaugh L.C., Brent A.E., Rosen V.,
RA   Olson E.N., Lassar A., Tabin C.J.;
RT   "Analysis of the tendon cell fate using Scleraxis, a specific marker for
RT   tendons and ligaments.";
RL   Development 128:3855-3866(2001).
CC   -!- FUNCTION: Plays an early essential role in mesoderm formation, as well
CC       as a later role in formation of somite-derived chondrogenic lineages.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Dimerizes and binds the E-box consensus sequence with E12.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- TISSUE SPECIFICITY: Expressed in the intersomitic, the superficial
CC       proximomedial limb mesenchyme and the subectodermal mesenchyme.
CC   -!- DEVELOPMENTAL STAGE: At stage 21, expressed in leg buds in a
CC       superficial proximomedial domain, expression is enhanced by stage 23.
CC       By stage 29, expression is elaborated to include both leg and wing. By
CC       stage 35, expressed in all muscle-to-bone attachment sites. Expressed
CC       also in a wing aponeurosis, a tendinous element arranged in flattened
CC       bands, and in some of the flattened sheets of connective tissue
CC       associated with muscle.
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DR   EMBL; AF505881; AAM33337.1; -; mRNA.
DR   RefSeq; NP_989584.1; NM_204253.1.
DR   AlphaFoldDB; P59101; -.
DR   SMR; P59101; -.
DR   Ensembl; ENSGALT00000062465; ENSGALP00000051519; ENSGALG00000043433.
DR   GeneID; 374101; -.
DR   KEGG; gga:374101; -.
DR   CTD; 642658; -.
DR   VEuPathDB; HostDB:geneid_374101; -.
DR   GeneTree; ENSGT00940000161897; -.
DR   InParanoid; P59101; -.
DR   OMA; LLVGETC; -.
DR   OrthoDB; 1511100at2759; -.
DR   PhylomeDB; P59101; -.
DR   PRO; PR:P59101; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000043433; Expressed in skeletal muscle tissue.
DR   ExpressionAtlas; P59101; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0071773; P:cellular response to BMP stimulus; IEP:UniProtKB.
DR   GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEP:UniProtKB.
DR   GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0061056; P:sclerotome development; IEP:UniProtKB.
DR   GO; GO:0035989; P:tendon development; IEP:UniProtKB.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..187
FT                   /note="Basic helix-loop-helix transcription factor
FT                   scleraxis"
FT                   /id="PRO_0000127437"
FT   DOMAIN          67..119
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          21..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          140..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   187 AA;  20562 MW;  F789683077C2FC1B CRC64;
     MSFAMLRPAA GRYLYPEISM LSEDEENGSE SSGSDEKPFH LDADGFGIKA GKRRSGKKAG
     RLHREPRQRH TANARERDRT NSVNTAFTAL RTLIPTEPAD RKLSKIETLR LASSYISHLG
     NVLLVGEACG DGQPCHTSPA FFHHGGGGGS PPPRDSENSQ PKQICTFCLS NQRKLSKDRD
     RKTAIRS