SCY1_DICDI
ID SCY1_DICDI Reviewed; 813 AA.
AC Q55GS2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Probable inactive serine/threonine-protein kinase scy1;
DE AltName: Full=N-terminal kinase-like protein;
DE AltName: Full=SCY1-like protein kinase 1;
GN Name=scy1; Synonyms=ntkl; ORFNames=DDB_G0267540;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=15548420; DOI=10.1016/s0074-7696(04)41003-1;
RA Graef R., Daunderer C., Schulz I.;
RT "Molecular and functional analysis of the dictyostelium centrosome.";
RL Int. Rev. Cytol. 241:155-202(2004).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AAFI02000003; EAL73223.1; -; Genomic_DNA.
DR RefSeq; XP_647112.1; XM_642020.1.
DR AlphaFoldDB; Q55GS2; -.
DR SMR; Q55GS2; -.
DR STRING; 44689.DDB0220502; -.
DR PaxDb; Q55GS2; -.
DR EnsemblProtists; EAL73223; EAL73223; DDB_G0267540.
DR GeneID; 8615916; -.
DR KEGG; ddi:DDB_G0267540; -.
DR dictyBase; DDB_G0267540; scy1.
DR eggNOG; KOG1243; Eukaryota.
DR HOGENOM; CLU_010392_1_0_1; -.
DR InParanoid; Q55GS2; -.
DR OMA; KFMHEAK; -.
DR PhylomeDB; Q55GS2; -.
DR PRO; PR:Q55GS2; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005813; C:centrosome; TAS:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat.
FT CHAIN 1..813
FT /note="Probable inactive serine/threonine-protein kinase
FT scy1"
FT /id="PRO_0000327440"
FT DOMAIN 1..264
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REPEAT 340..378
FT /note="HEAT 1"
FT REPEAT 380..416
FT /note="HEAT 2"
FT REPEAT 417..454
FT /note="HEAT 3"
FT REPEAT 456..493
FT /note="HEAT 4"
FT REPEAT 494..532
FT /note="HEAT 5"
FT REGION 539..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..696
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 92102 MW; 3B5569D3115432D1 CRC64;
MYIFKLMGQN LTASQSFPYN IGPIVTGYVG KSIWTLHSGT KKEDGSAVSI FSFDIKKNPS
KLEVAKNGFK RAKTTRHPNV LKYLDGLETE TNIYIVTEPI QLLDELLEDI RNFENAISWG
LYQEGLSFLN NKCNLTHGNI QSSSIFVNKG GDWQIGGLDF VSDVKDINNS ILRNHNDLIP
NKYKSPEIMK SQWQQIQQSP SYSIDSWMLG CLMYECYNGT MTKAEDIKNL DQIPKQLHQA
YQKSFAVKTE SRLNPQKFLE SPYFQNVFVE TLVFLENITL KDTFEKEQFF KKLDQHIEKI
PINICKFKIL PHLVTAFDLG PVNPRLLSTL LKIGSNLSTE EYNSRIVPSV VKWFACDDRA
LRINLLENLE HYIQHLNEAT INDQIFPHVV NGFNDNPTLK ELTIKSMLLF APKLQEKTMI
ILLKYFAALQ KDQQAGVRCN TTICLGRITE YMNEATKKRV LIPAFSTALK DPFVPSQNAA
IQAFMFTISN YSLEELATRV IPEVSRMLIS PEKSIRTSAF TAINMFLQKI EKNVDSILPS
SPQQQQQNGS TLNTNPNDPN QNSQDSMLGW AVGITKKLYS GENSPITATN NNNNTNTPPI
NQNNNNGYKS PPINQNNNQN NNQNNNQNNN QNNNQNNKSL QNKQPTKVIH DGWGDNDYQE
PPKKQTTTNT PSKSSKYKVE DNDDDDDDDE DYQEEDYSKY KEDLPRLTPK PSSTSSSSSS
TSNKLDNKPM SLVSKNKPKY SFDEEDTSSS SSNIVNKNNN NKNNNSDGWG DDDGWGNDEI
QVPSTTTSNI KKTVEKKTIV TASKSDGWDD GWD
