SCY1_YEAST
ID SCY1_YEAST Reviewed; 804 AA.
AC P53009; D6VU61;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Protein kinase-like protein SCY1;
GN Name=SCY1; OrderedLocusNames=YGL083W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Pietsch M., Gallwitz D.;
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9290212;
RX DOI=10.1002/(sici)1097-0061(19970915)13:11<1077::aid-yea152>3.0.co;2-y;
RA Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
RT "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
RT chromosome VII.";
RL Yeast 13:1077-1090(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- MISCELLANEOUS: Present with 1480 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X97305; CAA65975.1; -; Genomic_DNA.
DR EMBL; Z72605; CAA96788.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08022.1; -; Genomic_DNA.
DR PIR; S64090; S64090.
DR RefSeq; NP_011432.1; NM_001180948.1.
DR AlphaFoldDB; P53009; -.
DR SMR; P53009; -.
DR BioGRID; 33167; 50.
DR DIP; DIP-4400N; -.
DR STRING; 4932.YGL083W; -.
DR iPTMnet; P53009; -.
DR MaxQB; P53009; -.
DR PaxDb; P53009; -.
DR PRIDE; P53009; -.
DR EnsemblFungi; YGL083W_mRNA; YGL083W; YGL083W.
DR GeneID; 852797; -.
DR KEGG; sce:YGL083W; -.
DR SGD; S000003051; SCY1.
DR VEuPathDB; FungiDB:YGL083W; -.
DR eggNOG; KOG2137; Eukaryota.
DR GeneTree; ENSGT00880000138031; -.
DR HOGENOM; CLU_008724_3_0_1; -.
DR InParanoid; P53009; -.
DR OMA; MAHKCIP; -.
DR BioCyc; YEAST:G3O-30584-MON; -.
DR PRO; PR:P53009; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53009; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..804
FT /note="Protein kinase-like protein SCY1"
FT /id="PRO_0000097636"
FT DOMAIN 1..324
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 666..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 804 AA; 91001 MW; 457A81DDC7AB808E CRC64;
MMFWSSKTGI TSKYSFSSSP TFTAEPWSIY TGRPKSSSSS SPSKVSIFMF DKKQFENYLL
HYGIIKSKSG SRDKVLIQEA YEILRNQANN LAKLKHPNIL TLIEPLEEHS KNFMFVTEFV
TSSLETVFRE TDDEEQNFLQ GHVKDNIVVQ RGILQLVNAL DFVHNRASFV HLNIQPRAIF
INENSDWKIS GLGYLVKIPP GTNTSEYFLP QYDPRVPPFM HLQLNYTAPE IVFENTLTFK
NDYFSLGLLI YFLYTGKDLF RSENSTSEYK LEYNKFESKI STMSWDNIFS KVPQKLRHCI
PKLINRDIYS RYDNITLILD SEFFQDPLVK TLNFLDDLPT KNNEEKYVFL EGLVNLLPEF
PPALLQKKFL PILLELLSQF CAEKVVSDKC VGKSLDLIIK IGSTLSQLSF QEKVYPVLLS
DANFPVLLKK ATICLIDNLD TLKQKVKRSD FLENILKPLF NYVLHDSESD ITVVCQEKLL
SQIPLALEVL DFPTVKQFLL PLLSNLFTKT TSLTVKNTCV TCFQIMIEHK SIDSYTCSET
VLPLFKSMKT RDPRILSKLL KLFETVPLII TDEIVLVDQV LPLMWNYSMA STLTKSQYSG
YTKAINKMSS DIQKHHIAKL DDKVNDIGED AFHKVIEPTI MKKEDPETVA AKNIEVAAMQ
PVKKKTGSSY GETLPQSKSI LNSKPLNPKN ALATRGFPTR ILNSPPQTPS SRTGSKVMTK
GGSNDASSTK VEEEFNEFQS FSSTGSIRQT SAPSDVWMNS TPSPTPTSAS STNLPPGFSI
SLQPNKRKDG SSDIPRSNVY GSLI
