SCY2_DICDI
ID SCY2_DICDI Reviewed; 1125 AA.
AC Q55BQ3;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Probable inactive serine/threonine-protein kinase scy2;
DE AltName: Full=SCY1-like protein kinase 2;
GN Name=scy2; ORFNames=DDB_G0270808;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AAFI02000005; EAL72754.1; -; Genomic_DNA.
DR RefSeq; XP_646778.1; XM_641686.1.
DR AlphaFoldDB; Q55BQ3; -.
DR STRING; 44689.DDB0231323; -.
DR PaxDb; Q55BQ3; -.
DR EnsemblProtists; EAL72754; EAL72754; DDB_G0270808.
DR GeneID; 8617751; -.
DR KEGG; ddi:DDB_G0270808; -.
DR dictyBase; DDB_G0270808; scy2.
DR eggNOG; KOG2137; Eukaryota.
DR HOGENOM; CLU_279832_0_0_1; -.
DR InParanoid; Q55BQ3; -.
DR OMA; MAHKCIP; -.
DR PhylomeDB; Q55BQ3; -.
DR PRO; PR:Q55BQ3; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding; Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..1125
FT /note="Probable inactive serine/threonine-protein kinase
FT scy2"
FT /id="PRO_0000362071"
FT DOMAIN 30..348
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 633..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 36..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 64
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 1125 AA; 125380 MW; 2DE8A6980E68972B CRC64;
MDTTKSFNFK EKVRGFLGSA ASVISPIKDH DLKEVVGQDK FWKIYQSTKK TTNTECSLFV
FEKKLYEKVS KSNLENVITF LKKEATTLQR LRHPSILQVV SVMEETKTHI HFATEPILAT
LEDLLGYYRQ RKKSTVDQSS QSEEGYKKKD FTFEELELKA GIFQILDGLL FLNQTAKLLH
RNISPESIFI TKDLKWKLGG LGFTCSIETK EPPISNLSLQ DLREYQYISG GGGGESSNNS
NYILPQLDYL APEFISQRKF ETNSDLFSIG RLIFELSINL EQKALDSHLI SQLPKLGVIS
YYNTMIEQVR RQSTMNTQRS DSAKVCTILL GDPMLRGDLE NFIRSSFFQD VLTKTLLYLA
NISQKEDESK LQFFRGLLRI VQQFSPRIQN NYILPVLLSE ISNDRIIYVL LPNIMSISAN
HVKKETFQSK VLPAISNILQ SKEPKPEVLS CVLENLPMLL QKCSLDQIKK ILLPICLGSM
CGPTNEIIFQ CLSTAQPIAK FFDTDMISVA VIPRLTNLCV GGFPVHIRTK AIQWFTLLVP
SIEKKIIVDS LLPNLEKILA GDNSPVILQS LVETYEALSK KLGGELLAKS VLPALIPLSS
DKHIDLEQFK TVMKVIRDIL NTYEQERINE LSNLQRYTSP TPTKDENDTS FITVNNNNNN
NNNISPTPIN LTLPNSFGIT PITTTATTQP SSSPSMLFPQ PPQTSQPSSS PLSSSSSGTT
SNPFNSVLSG NNKALIDSPD FGSTYISQPP STQQLSSNIS LTLPKSPPTT RPTVSNSSNS
LFPTTNTTNN NNNNNNINNN NSSNNGSNYN SFNNSSFQNN SNQPVQPPPQ QQQPLSFNSS
FDFGSNLQPI KPTNTIAAQT PLPQPKLSYN SSFDIGNSNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNLNSFS NFGNNSSNGM NNSNNNFALN SGSTLPIKST STSKYDINLE
DHVNSSSNSF SNNSFSNNNN SSSNNNTNNN NNNNGVGNFN SSNSFSSSSQ SNYGFDQPLN
PTTNSNHNSY GNNNYGNNSN NNNNNNTNSM NSSFKNMDLN QNNSYNNTLN DFNSFHNNVN
SSFNMNPPSI TKNVNFNSNN YNNNNNNNNN NNNNNYNNNN NSNFW
