ID   SCYL1_XENLA             Reviewed;         827 AA.
AC   Q561M0; Q6DKA9;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=N-terminal kinase-like protein;
DE   AltName: Full=SCY1-like protein 1;
GN   Name=scyl1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye, and Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates COPI-mediated retrograde protein traffic at the
CC       interface between the Golgi apparatus and the endoplasmic reticulum.
CC       Involved in the maintenance of the Golgi apparatus morphology. Has no
CC       detectable kinase activity in vitro. {ECO:0000250|UniProtKB:Q96KG9}.
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. {ECO:0000305}.
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DR   EMBL; BC074449; AAH74449.1; -; mRNA.
DR   EMBL; BC093531; AAH93531.1; -; mRNA.
DR   RefSeq; NP_001085304.1; NM_001091835.1.
DR   AlphaFoldDB; Q561M0; -.
DR   SMR; Q561M0; -.
DR   BioGRID; 101874; 1.
DR   IntAct; Q561M0; 1.
DR   DNASU; 443710; -.
DR   GeneID; 443710; -.
DR   KEGG; xla:443710; -.
DR   CTD; 443710; -.
DR   Xenbase; XB-GENE-5843636; scyl1.L.
DR   OMA; LIRDQAN; -.
DR   OrthoDB; 1074965at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 443710; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..827
FT                   /note="N-terminal kinase-like protein"
FT                   /id="PRO_0000249544"
FT   DOMAIN          16..309
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REPEAT          345..383
FT                   /note="HEAT 1"
FT   REPEAT          384..422
FT                   /note="HEAT 2"
FT   REPEAT          502..540
FT                   /note="HEAT 3"
FT   REGION          580..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          788..817
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        650..690
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        716..757
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        789..827
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  91303 MW;  1D72BC52BE565FDA CRC64;
     MWFWSRDPAR DFPYDVTGER EELPGGWGIQ KGKKKTGGDP VSVFTYEIRP GAEEQTQAAK
     TASKRIKTLK HPNILSYVDG LETDKCLYIV TEPVTPLETY VKLRTDSGGV SELEISWGLH
     QIVKALSFLV NDGNLIHNNV CMSAVFVDRA GEWKLGGLDY MYTAGAENTA PRKGVEMEKY
     NPPEKTDRSK TSKEKWSADM WCLGCLIWEV FNGPLPRPTA LRSLGKIAKS LVPHYCELVG
     ANPKIRPNPS RFLQNCRSPG GFFCNSFVET NLFLEEIQIK DPAEKQTFFE QLSENLDSFP
     EDFCRHKILP QLLTAFEFGS AGAVVLPPLF KIGKFLNADE YQQKIIPVVV KMFSSTDRAM
     RIRLLQQMEN FIQYLNEPTV NAQIFPHVVH GFMDTNPAIR EQTVKSMLLL APKLNENNLN
     MDLMKHFARL QARDDQGPIR CNTTVCLGKI APYLNPATRQ RVLISAFSRA TKDPFAPSRA
     AGVLGFAATH NFYSMADCAG KVLPVLCGVT LDPEKNVREQ AFKTIRSFLD KLETVSGDPS
     QLAELEKDVH TASASPSVVG GWAGWAVTGV SSLTSKFIRT GGGAQDASPS EGAPAPPATI
     EASKPDTVPS PSAPPAASTT PSSYEPEEEK GASDSLDRWD DEDWGSLEDT DQSKGQTVND
     DWDTDWGQSK TQQKTVHSSS SSSKGEQVLH PPNKTSALDD GWGWDDAFPT VPPAKKPTAS
     KSQQPEEGTR PASDYNWESP GTAGQQGDFF TTLSEHSSQK TDDSRNSDSP GDWGGEDNWE
     SVEADQGLSK AEIARKKREE RQKEIEAKRA ERRAAKGPLK LGVRKLD