SD18_ARATH
ID SD18_ARATH Reviewed; 850 AA.
AC O81905; A3RCC7; A7Y5X0; D6NTP9; D6NTQ1; D6NTQ4; D6NTQ5; D6NTQ8; D6NTR0;
AC D6NTR1; D6NTR5; D6NTR7; D6NTR8; D6NTS3; D6NTS6; D6NTS8; D6NTT4; D6NTV2;
AC D6NTX2; Q9S971;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Receptor-like serine/threonine-protein kinase SD1-8;
DE EC=2.7.11.1;
DE AltName: Full=Arabidopsis thaliana receptor kinase 3;
DE AltName: Full=S-domain-1 (SD1) receptor kinase 8;
DE Short=SD1-8;
DE Flags: Precursor;
GN Name=SD18; Synonyms=ARK3; OrderedLocusNames=At4g21380; ORFNames=T6K22.110;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. C24;
RX PubMed=7866027; DOI=10.2307/3869911;
RA Dwyer K.G., Kandasamy M.K., Mahosky D.I., Acciai J., Kudish B.I.,
RA Miller J.E., Nasrallah M.E., Nasrallah J.B.;
RT "A superfamily of S locus-related sequences in Arabidopsis: diverse
RT structures and expression patterns.";
RL Plant Cell 6:1829-1843(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASN-102; VAL-256; THR-270;
RP MET-366; LEU-375; LYS-384 AND ILE-405.
RC STRAIN=cv. C24;
RX PubMed=17237349; DOI=10.1105/tpc.106.048199;
RA Sherman-Broyles S., Boggs N., Farkas A., Liu P., Vrebalov J.,
RA Nasrallah M.E., Nasrallah J.B.;
RT "S locus genes and the evolution of self-fertility in Arabidopsis
RT thaliana.";
RL Plant Cell 19:94-106(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-256.
RC STRAIN=cv. Cvi-0;
RX PubMed=17656687; DOI=10.1126/science.1143153;
RA Tang C., Toomajian C., Sherman-Broyles S., Plagnol V., Guo Y.-L., Hu T.T.,
RA Clark R.M., Nasrallah J.B., Weigel D., Nordborg M.;
RT "The evolution of selfing in Arabidopsis thaliana.";
RL Science 317:1070-1072(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-432, AND VARIANTS THR-34; ILE-45;
RP ASN-63; THR-74; ASN-102; ARG-150; GLY-173; ILE-240; VAL-256;
RP 256-ILE-THR-257 DELINS VAL-SER; 256-ILE--SER-259 DELINS VAL-THR-LYS-ARG;
RP THR-270; ILE-304; THR-346; CYS-361; ARG-366; MET-366; LEU-375; LYS-384;
RP SER-386 AND ILE-405.
RC STRAIN=cv. Ag-0, cv. An-1, cv. Bay-0, cv. Bil-5, cv. Bil-7, cv. Bor-1,
RC cv. Bor-4, cv. Br-0, cv. Bur-0, cv. C24, cv. CIBC-17, cv. CIBC-5, cv. Ct-1,
RC cv. Ed-1, cv. Ed-2, cv. Edi-0, cv. Ei-2, cv. Est-1, cv. Fab-2, cv. Fab-4,
RC cv. Fei-0, cv. Ga-0, cv. Ge-0, cv. Goettingen-22, cv. Goettingen-7,
RC cv. Gy-0, cv. HR-10, cv. HR-5, cv. Ler-1, cv. Ll-0, cv. Lov-1, cv. Lov-5,
RC cv. Lp2-2, cv. Lp2-6, cv. Lz-0, cv. Mr-0, cv. Mrk-0, cv. Ms-0, cv. Mt-0,
RC cv. Mz-0, cv. N13 Konchezero, cv. Nd-1, cv. NFA-10, cv. NFA-8, cv. Nok-3,
RC cv. Omo2-1, cv. Omo2-3, cv. Oy-0, cv. Pu2-23, cv. Pu2-7, cv. Ra-0,
RC cv. REN-11, cv. Se-0, cv. Spr1-2, cv. Spr1-6, cv. Sq-1, cv. Sq-8,
RC cv. Tamm-2, cv. Tamm-27, cv. Ts-1, cv. Ts-5, cv. Ull2-3, cv. Ull2-5,
RC cv. Uod-1, cv. Uod-7, cv. Var2-1, cv. Var2-6, cv. Wa-1, cv. Wassilewskija,
RC cv. Wassilewskija-2, cv. Wei-0, cv. Wt-5, cv. Zdr-1, and cv. Zdr-6;
RX PubMed=20400945; DOI=10.1038/nature08927;
RA Tsuchimatsu T., Suwabe K., Shimizu-Inatsugi R., Isokawa S., Pavlidis P.,
RA Stadler T., Suzuki G., Takayama S., Watanabe M., Shimizu K.K.;
RT "Evolution of self-compatibility in Arabidopsis by a mutation in the male
RT specificity gene.";
RL Nature 464:1342-1346(2010).
RN [9]
RP INDUCTION BY WOUNDING AND XANTHOMONAS CAMPESTRIS.
RX PubMed=11814694; DOI=10.1016/s0378-1119(01)00821-6;
RA Pastuglia M., Swarup R., Rocher A., Saindrenan P., Roby D., Dumas C.,
RA Cock J.M.;
RT "Comparison of the expression patterns of two small gene families of S gene
RT family receptor kinase genes during the defence response in Brassica
RT oleracea and Arabidopsis thaliana.";
RL Gene 282:215-225(2002).
RN [10]
RP SUBCELLULAR LOCATION.
RC STRAIN=cv. La-0;
RX PubMed=14506206; DOI=10.1074/mcp.t300006-mcp200;
RA Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
RT "Large-scale analysis of in vivo phosphorylated membrane proteins by
RT immobilized metal ion affinity chromatography and mass spectrometry.";
RL Mol. Cell. Proteomics 2:1234-1243(2003).
RN [11]
RP GENE FAMILY, NOMENCLATURE, AND INTERACTION WITH PUB9; PUB13; PUB14 AND
RP PUB38.
RX PubMed=18552232; DOI=10.1104/pp.108.123380;
RA Samuel M.A., Mudgil Y., Salt J.N., Delmas F., Ramachandran S., Chilelli A.,
RA Goring D.R.;
RT "Interactions between the S-domain receptor kinases and AtPUB-ARM E3
RT ubiquitin ligases suggest a conserved signaling pathway in Arabidopsis.";
RL Plant Physiol. 147:2084-2095(2008).
CC -!- FUNCTION: Involved in the regulation of cellular expansion and
CC differentiation. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SUBUNIT: Interacts with PUB9, PUB13, PUB14 and PUB38.
CC {ECO:0000269|PubMed:18552232}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14506206};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:14506206}.
CC -!- TISSUE SPECIFICITY: Expressed in the root-hypocotyl transition zone, at
CC the base of lateral roots, axillary buds and pedicels.
CC {ECO:0000269|PubMed:7866027}.
CC -!- INDUCTION: By wounding and Xanthomonas campestris pv. campestris.
CC {ECO:0000269|PubMed:11814694}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; EF182720; ABN05291.1; -; Genomic_DNA.
DR EMBL; EF637083; ABV21214.1; -; Genomic_DNA.
DR EMBL; AL031187; CAA20203.1; -; Genomic_DNA.
DR EMBL; AL161555; CAB81245.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84446.1; -; Genomic_DNA.
DR EMBL; AK118895; BAC43479.1; -; mRNA.
DR EMBL; BT006032; AAP04019.1; -; mRNA.
DR EMBL; GU723792; ADG01655.1; -; Genomic_DNA.
DR EMBL; GU723793; ADG01656.1; -; Genomic_DNA.
DR EMBL; GU723794; ADG01657.1; -; Genomic_DNA.
DR EMBL; GU723795; ADG01658.1; -; Genomic_DNA.
DR EMBL; GU723796; ADG01659.1; -; Genomic_DNA.
DR EMBL; GU723797; ADG01660.1; -; Genomic_DNA.
DR EMBL; GU723798; ADG01661.1; -; Genomic_DNA.
DR EMBL; GU723799; ADG01662.1; -; Genomic_DNA.
DR EMBL; GU723800; ADG01663.1; -; Genomic_DNA.
DR EMBL; GU723801; ADG01664.1; -; Genomic_DNA.
DR EMBL; GU723802; ADG01665.1; -; Genomic_DNA.
DR EMBL; GU723803; ADG01666.1; -; Genomic_DNA.
DR EMBL; GU723804; ADG01667.1; -; Genomic_DNA.
DR EMBL; GU723805; ADG01668.1; -; Genomic_DNA.
DR EMBL; GU723806; ADG01669.1; -; Genomic_DNA.
DR EMBL; GU723807; ADG01670.1; -; Genomic_DNA.
DR EMBL; GU723808; ADG01671.1; -; Genomic_DNA.
DR EMBL; GU723809; ADG01672.1; -; Genomic_DNA.
DR EMBL; GU723810; ADG01673.1; -; Genomic_DNA.
DR EMBL; GU723811; ADG01674.1; -; Genomic_DNA.
DR EMBL; GU723812; ADG01675.1; -; Genomic_DNA.
DR EMBL; GU723813; ADG01676.1; -; Genomic_DNA.
DR EMBL; GU723814; ADG01677.1; -; Genomic_DNA.
DR EMBL; GU723815; ADG01678.1; -; Genomic_DNA.
DR EMBL; GU723816; ADG01679.1; -; Genomic_DNA.
DR EMBL; GU723817; ADG01680.1; -; Genomic_DNA.
DR EMBL; GU723818; ADG01681.1; -; Genomic_DNA.
DR EMBL; GU723819; ADG01682.1; -; Genomic_DNA.
DR EMBL; GU723820; ADG01683.1; -; Genomic_DNA.
DR EMBL; GU723821; ADG01684.1; -; Genomic_DNA.
DR EMBL; GU723822; ADG01685.1; -; Genomic_DNA.
DR EMBL; GU723823; ADG01686.1; -; Genomic_DNA.
DR EMBL; GU723824; ADG01687.1; -; Genomic_DNA.
DR EMBL; GU723825; ADG01688.1; -; Genomic_DNA.
DR EMBL; GU723826; ADG01689.1; -; Genomic_DNA.
DR EMBL; GU723827; ADG01690.1; -; Genomic_DNA.
DR EMBL; GU723828; ADG01691.1; -; Genomic_DNA.
DR EMBL; GU723829; ADG01692.1; -; Genomic_DNA.
DR EMBL; GU723830; ADG01693.1; -; Genomic_DNA.
DR EMBL; GU723831; ADG01694.1; -; Genomic_DNA.
DR EMBL; GU723832; ADG01695.1; -; Genomic_DNA.
DR EMBL; GU723833; ADG01696.1; -; Genomic_DNA.
DR EMBL; GU723834; ADG01697.1; -; Genomic_DNA.
DR EMBL; GU723835; ADG01698.1; -; Genomic_DNA.
DR EMBL; GU723836; ADG01699.1; -; Genomic_DNA.
DR EMBL; GU723837; ADG01700.1; -; Genomic_DNA.
DR EMBL; GU723838; ADG01701.1; -; Genomic_DNA.
DR EMBL; GU723839; ADG01702.1; -; Genomic_DNA.
DR EMBL; GU723840; ADG01703.1; -; Genomic_DNA.
DR EMBL; GU723841; ADG01704.1; -; Genomic_DNA.
DR EMBL; GU723842; ADG01705.1; -; Genomic_DNA.
DR EMBL; GU723843; ADG01706.1; -; Genomic_DNA.
DR EMBL; GU723844; ADG01707.1; -; Genomic_DNA.
DR EMBL; GU723845; ADG01708.1; -; Genomic_DNA.
DR EMBL; GU723846; ADG01709.1; -; Genomic_DNA.
DR EMBL; GU723847; ADG01710.1; -; Genomic_DNA.
DR EMBL; GU723848; ADG01711.1; -; Genomic_DNA.
DR EMBL; GU723849; ADG01712.1; -; Genomic_DNA.
DR EMBL; GU723850; ADG01713.1; -; Genomic_DNA.
DR EMBL; GU723851; ADG01714.1; -; Genomic_DNA.
DR EMBL; GU723852; ADG01715.1; -; Genomic_DNA.
DR EMBL; GU723853; ADG01716.1; -; Genomic_DNA.
DR EMBL; GU723854; ADG01717.1; -; Genomic_DNA.
DR EMBL; GU723855; ADG01718.1; -; Genomic_DNA.
DR EMBL; GU723856; ADG01719.1; -; Genomic_DNA.
DR EMBL; GU723857; ADG01720.1; -; Genomic_DNA.
DR EMBL; GU723858; ADG01721.1; -; Genomic_DNA.
DR EMBL; GU723859; ADG01722.1; -; Genomic_DNA.
DR EMBL; GU723860; ADG01723.1; -; Genomic_DNA.
DR EMBL; GU723861; ADG01724.1; -; Genomic_DNA.
DR EMBL; GU723862; ADG01725.1; -; Genomic_DNA.
DR EMBL; GU723863; ADG01726.1; -; Genomic_DNA.
DR EMBL; GU723864; ADG01727.1; -; Genomic_DNA.
DR EMBL; GU723865; ADG01728.1; -; Genomic_DNA.
DR PIR; T05180; T05180.
DR RefSeq; NP_193869.1; NM_118258.3.
DR AlphaFoldDB; O81905; -.
DR SMR; O81905; -.
DR BioGRID; 13181; 17.
DR IntAct; O81905; 9.
DR STRING; 3702.AT4G21380.1; -.
DR iPTMnet; O81905; -.
DR PaxDb; O81905; -.
DR PRIDE; O81905; -.
DR ProteomicsDB; 232872; -.
DR EnsemblPlants; AT4G21380.1; AT4G21380.1; AT4G21380.
DR GeneID; 827890; -.
DR Gramene; AT4G21380.1; AT4G21380.1; AT4G21380.
DR KEGG; ath:AT4G21380; -.
DR Araport; AT4G21380; -.
DR TAIR; locus:2141181; AT4G21380.
DR eggNOG; ENOG502QS2H; Eukaryota.
DR HOGENOM; CLU_000288_116_1_1; -.
DR InParanoid; O81905; -.
DR OrthoDB; 684563at2759; -.
DR PhylomeDB; O81905; -.
DR PRO; PR:O81905; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O81905; baseline and differential.
DR Genevisible; O81905; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0005773; C:vacuole; HDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; ISS:TAIR.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR GO; GO:0048544; P:recognition of pollen; IEA:InterPro.
DR CDD; cd00028; B_lectin; 1.
DR Gene3D; 2.90.10.10; -; 1.
DR InterPro; IPR001480; Bulb-type_lectin_dom.
DR InterPro; IPR036426; Bulb-type_lectin_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR022126; S-locus_recpt_kinase.
DR InterPro; IPR021820; S-locus_recpt_kinase_C.
DR InterPro; IPR000858; S_locus_glycoprot_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR024171; SRK-like_kinase.
DR Pfam; PF01453; B_lectin; 1.
DR Pfam; PF11883; DUF3403; 1.
DR Pfam; PF12398; DUF3660; 1.
DR Pfam; PF08276; PAN_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00954; S_locus_glycop; 1.
DR PIRSF; PIRSF000641; SRK; 1.
DR SMART; SM00108; B_lectin; 1.
DR SMART; SM00473; PAN_AP; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF51110; SSF51110; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50927; BULB_LECTIN; 1.
DR PROSITE; PS50948; PAN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell membrane; Disulfide bond; EGF-like domain; Glycoprotein;
KW Kinase; Lectin; Membrane; Nucleotide-binding; Receptor; Reference proteome;
KW Serine/threonine-protein kinase; Signal; Transferase; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..850
FT /note="Receptor-like serine/threonine-protein kinase SD1-8"
FT /id="PRO_0000401296"
FT TOPO_DOM 27..441
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 463..850
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..153
FT /note="Bulb-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00038"
FT DOMAIN 292..328
FT /note="EGF-like"
FT DOMAIN 347..428
FT /note="PAN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00315"
FT DOMAIN 526..807
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 615..632
FT /note="CaM-binding"
FT /evidence="ECO:0000250"
FT ACT_SITE 651
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 532..540
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 554
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 242
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 387
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 437
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 296..308
FT /evidence="ECO:0000250"
FT DISULFID 302..316
FT /evidence="ECO:0000250"
FT DISULFID 378..403
FT /evidence="ECO:0000250"
FT DISULFID 382..388
FT /evidence="ECO:0000250"
FT VARIANT 34
FT /note="A -> T (in strain: cv. Bor-1, cv. Pu2-23, cv. Pu2-7,
FT cv. Wa-1, cv. Wassilewskija)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 45
FT /note="T -> I (in strain: cv. Bay-0, cv. Bil-5, cv. Bil-7,
FT cv. Bor-1, cv. Bor-4, cv. Br-0, cv. Bur-0, cv. Ed-1, cv.
FT Edi-0, cv. Fab-2, cv. Fab-4, cv. Ga-0, cv. Ge-0, cv.
FT Goettingen-7, cv. HR-10, cv. Lov-1, cv. Lov-5, cv. Lz-0,
FT cv. Mr-0, cv. Mrk-0, cv. Mz-0, cv. Nd-1, cv. Nok-3, cv.
FT Omo2-1, cv. Omo2-3, cv. Oy-0, cv. Pu2-23, cv. Pu2-7, cv.
FT Ra-0, cv. Spr1-2, cv. Sq-8, cv. Ts-1, cv. Uod-1, cv. Var2-
FT 1, cv. Var2-6, cv. Wa-1, cv. Wassilewskija, cv. Wt-5, cv.
FT Zdr-1, cv. Zdr-6)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 63
FT /note="D -> N (in strain: cv. Bay-0, cv. Bil-5, cv. Bil-7,
FT cv. Bor-1, cv. Br-0, cv. Bur-0, cv. Ed-1, cv. Edi-0, cv.
FT Fab-2, cv. Fab-4, cv. Ga-0, cv. Ge-0, cv. Goettingen-7, cv.
FT HR-10, cv. Lov-1, cv. Lov-5, cv. Lz-0, cv. Mr-0, cv. Mrk-0,
FT cv. Mz-0, cv. Nd-1, cv. Nok-3, cv. Omo2-1, cv. Omo2-3, cv.
FT Oy-0, cv. Pu2-23, cv. Pu2-7, cv. Ra-0, cv. Spr1-2, cv. Sq-
FT 8, cv. Ts-1, cv. Uod-1, cv. Var2-1, cv. Var2-6, cv. Wa-1,
FT cv. Wassilewskija, cv. Wt-5, cv. Zdr-1, cv. Zdr-6)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 74
FT /note="A -> T (in strain: cv. Bay-0, cv. Bil-5, cv. Bil-7,
FT cv. Bor-1, cv. Br-0, cv. Bur-0, cv. Ed-1, cv. Edi-0, cv.
FT Fab-2, cv. Fab-4, cv. Ga-0, cv. Ge-0, cv. Goettingen-7, cv.
FT HR-10, cv. Lov-1, cv. Lov-5, cv. Lz-0, cv. Mr-0, cv. Mrk-0,
FT cv. Mz-0, cv. Nd-1, cv. Nok-3, cv. Omo2-1, cv. Omo2-3, cv.
FT Oy-0, cv. Pu2-23, cv. Pu2-7, cv. Ra-0, cv. Spr1-2, cv. Sq-
FT 8, cv. Ts-1, cv. Uod-1, cv. Var2-1, cv. Var2-6, cv. Wa-1,
FT cv. Wassilewskija, cv. Wt-5, cv. Zdr-1, cv. Zdr-6)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 102
FT /note="S -> N (in strain: cv. Ag-0, cv. An-1, cv. Bay-0,
FT cv. Bil-5, cv. Bil-7, cv. Bor-1, cv. Br-0, cv. Bur-0, cv.
FT C24, cv. CIBC-17, cv. Ct-1, cv. Ed-1, cv. Edi-0, cv. Fab-2,
FT cv. Fab-4, cv. Fei-0, cv. Ga-0, cv. Ge-0, cv. Goettingen-
FT 22, cv. Goettingen-7, cv. Gy-0, cv. HR-10, cv. Ll-0, cv.
FT Lov-1, cv. Lov-5, cv. Lz-0, cv. Mr-0, cv. Mrk-0, cv. Mt-0,
FT cv. Mz-0, cv. NFA-10, cv. NFA-8, cv. Nd-1, cv. Nok-3, cv.
FT Omo2-1, cv. Omo2-3, cv. Oy-0, cv. Pu2-23, cv. Pu2-7, cv.
FT REN-11, cv. Ra-0, cv. Se-0, cv. Spr1-2, cv. Sq-1, cv. Sq-8,
FT cv. Ts-1, cv. Ts-5, cv. Ull2-3, cv. Uod-1, cv. Uod-7, cv.
FT Var2-1, cv. Var2-6, cv. Wa-1, cv. Wassilewskija, cv. Wei-0,
FT cv. Wt-5, cv. Zdr-1)"
FT /evidence="ECO:0000269|PubMed:17237349,
FT ECO:0000269|PubMed:20400945"
FT VARIANT 150
FT /note="G -> R (in strain: cv. Est-1, cv. Wassilewskija-2)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 173
FT /note="A -> G (in strain: cv. CIBC-5, cv. Ed-2, cv. HR-5,
FT cv. Spr1-6, cv. Ull2-5)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 240
FT /note="V -> I (in strain: cv. Ler-1, cv. Lp2-2, cv. Lp2-6,
FT cv. Tamm-2, cv. Tamm-27)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 256..259
FT /note="ITKS -> VTKR (in strain: cv. HR-10)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 256..257
FT /note="IT -> VS (in strain: cv. Edi-0, cv. Ga-0, cv. Mrk-0,
FT cv. Mz-0, cv. Nd-1, cv. Omo2-3, cv. Oy-0, cv. Sq-8, cv. Ts-
FT 1, cv. Zdr-1)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 256
FT /note="I -> V (in strain: cv. Ag-0, cv. An-1, cv. Bay-0,
FT cv. Bil-5, cv. Bil-7, cv. Bor-1, cv. Br-0, cv. Bur-0, cv.
FT C24, cv. CIBC-17, cv. Ct-1, cv. Cvi-0, cv. Ed-1, cv. Fab-2,
FT cv. Fab-4, cv. Fei-0, cv. Ge-0, cv. Goettingen-22, cv.
FT Goettingen-7, cv. Gy-0, cv. Ll-0, cv. Lov-1, cv. Lov-5, cv.
FT Lz-0, cv. Mr-0, cv. Mt-0, cv. NFA-10, cv. NFA-8, cv. Nok-3,
FT cv. Omo2-1, cv. Pu2-23, cv. Pu2-7, cv. REN-11, cv. Ra-0,
FT cv. Se-0, cv. Spr1-2, cv. Sq-1, cv. Ts-5, cv. Ull2-3, cv.
FT Uod-1, cv. Uod-7, cv. Var2-1, cv. Var2-6, cv. Wa-1, cv.
FT Wassilewskija, cv. Wei-0, cv. Wt-5)"
FT /evidence="ECO:0000269|PubMed:17237349,
FT ECO:0000269|PubMed:17656687, ECO:0000269|PubMed:20400945"
FT VARIANT 270
FT /note="S -> T (in strain: cv. Ag-0, cv. An-1, cv. Bay-0,
FT cv. Bil-5, cv. Bil-7, cv. Bor-1, cv. Br-0, cv. Bur-0, cv.
FT C24, cv. CIBC-17, cv. Ct-1, cv. Ed-1, cv. Edi-0, cv. Fab-2,
FT cv. Fab-4, cv. Fei-0, cv. Ga-0, cv. Ge-0, cv. Goettingen-
FT 22, cv. Goettingen-7, cv. Gy-0, cv. HR-10, cv. Ll-0, cv.
FT Lov-1, cv. Lov-5, cv. Lz-0, cv. Mr-0, cv. Mrk-0, cv. Mt-0,
FT cv. Mz-0, cv. NFA-10, cv. NFA-8, cv. Nd-1, cv. Nok-3, cv.
FT Omo2-1, cv. Omo2-3, cv. Oy-0, cv. Pu2-23, cv. Pu2-7, cv.
FT REN-11, cv. Ra-0, cv. Se-0, cv. Spr1-2, cv. Sq-1, cv. Sq-8,
FT cv. Ts-1, cv. Ts-5, cv. Ull2-3, cv. Uod-1, cv. Uod-7, cv.
FT Var2-1, cv. Var2-6, cv. Wa-1, cv. Wassilewskija, cv. Wei-0,
FT cv. Wt-5, cv. Zdr-1)"
FT /evidence="ECO:0000269|PubMed:17237349,
FT ECO:0000269|PubMed:20400945"
FT VARIANT 304
FT /note="V -> I (in strain: cv. Goettingen-7)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 346
FT /note="S -> T (in strain: cv. CIBC-5, cv. Ed-2, cv. HR-5,
FT cv. Spr1-6, cv. Ull2-5)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 361
FT /note="L -> C (in strain: cv. Lz-0)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 366
FT /note="T -> M (in strain: cv. Ag-0, cv. An-1, cv. Bay-0,
FT cv. Bil-5, cv. Bil-7, cv. Bor-1, cv. Br-0, cv. Bur-0, cv.
FT C24, cv. CIBC-17, cv. Ct-1, cv. Ed-1, cv. Edi-0, cv. Fab-4,
FT cv. Fei-0, cv. Ga-0, cv. Ge-0, cv. Goettingen-22, cv.
FT Goettingen-7, cv. Gy-0, cv. HR-10, cv. Ll-0, cv. Lov-1, cv.
FT Lov-5, cv. Lz-0, cv. Mr-0, cv. Mrk-0, cv. Mz-0, cv. NFA-10,
FT cv. NFA-8, cv. Nd-1, cv. Nok-3, cv. Omo2-1, cv. Omo2-3, cv.
FT Oy-0, cv. Pu2-23, cv. Pu2-7, cv. REN-11, cv. Ra-0, cv. Se-
FT 0, cv. Sq-1, cv. Sq-8, cv. Ts-1, cv. Ts-5, cv. Ull2-3, cv.
FT Uod-1, cv. Uod-7, cv. Wa-1, cv. Wassilewskija, cv. Wei-0,
FT cv. Wt-5, cv. Zdr-1)"
FT /evidence="ECO:0000269|PubMed:17237349,
FT ECO:0000269|PubMed:20400945"
FT VARIANT 366
FT /note="T -> R (in strain: cv. C24, cv. Mt-0)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 375
FT /note="V -> L (in strain: cv. Ag-0, cv. An-1, cv. Bay-0,
FT cv. Bil-5, cv. Bil-7, cv. Bor-1, cv. Br-0, cv. Bur-0, cv.
FT C24, cv. CIBC-17, cv. Ct-1, cv. Ed-1, cv. Edi-0, cv. Fab-4,
FT cv. Fei-0, cv. Ga-0, cv. Ge-0, cv. Goettingen-22, cv.
FT Goettingen-7, cv. Gy-0, cv. HR-10, cv. Ll-0, cv. Lov-1, cv.
FT Lov-5, cv. Lz-0, cv. Mr-0, cv. Mrk-0, cv. Mt-0, cv. Mz-0,
FT cv. NFA-10, cv. NFA-8, cv. Nd-1, cv. Nok-3, cv. Omo2-1, cv.
FT Omo2-3, cv. Oy-0, cv. Pu2-23, cv. Pu2-7, cv. REN-11, cv.
FT Ra-0, cv. Se-0, cv. Sq-1, cv. Sq-8, cv. Ts-1, cv. Ts-5, cv.
FT Ull2-3, cv. Uod-1, cv. Uod-7, cv. Wa-1, cv. Wassilewskija,
FT cv. Wei-0, cv. Wt-5, cv. Zdr-1)"
FT /evidence="ECO:0000269|PubMed:17237349,
FT ECO:0000269|PubMed:20400945"
FT VARIANT 384
FT /note="R -> K (in strain: cv. Ag-0, cv. An-1, cv. Bay-0,
FT cv. Bil-5, cv. Bil-7, cv. Bor-1, cv. Br-0, cv. Bur-0, cv.
FT C24, cv. CIBC-17, cv. Ct-1, cv. Ed-1, cv. Edi-0, cv. Fab-4,
FT cv. Fei-0, cv. Ga-0, cv. Ge-0, cv. Goettingen-22, cv.
FT Goettingen-7, cv. Gy-0, cv. HR-10, cv. Ll-0, cv. Lov-1, cv.
FT Lov-5, cv. Lz-0, cv. Mr-0, cv. Mrk-0, cv. Mt-0, cv. Mz-0,
FT cv. NFA-10, cv. NFA-8, cv. Nd-1, cv. Nok-3, cv. Omo2-1, cv.
FT Omo2-3, cv. Oy-0, cv. Pu2-23, cv. Pu2-7, cv. REN-11, cv.
FT Ra-0, cv. Se-0, cv. Sq-1, cv. Sq-8, cv. Ts-1, cv. Ts-5, cv.
FT Ull2-3, cv. Uod-1, cv. Uod-7, cv. Wa-1, cv. Wassilewskija,
FT cv. Wei-0, cv. Wt-5, cv. Zdr-1)"
FT /evidence="ECO:0000269|PubMed:17237349,
FT ECO:0000269|PubMed:20400945"
FT VARIANT 386
FT /note="C -> S (in strain: cv. Fab-2)"
FT /evidence="ECO:0000269|PubMed:20400945"
FT VARIANT 405
FT /note="T -> I (in strain: cv. Ag-0, cv. An-1, cv. Bay-0,
FT cv. Bil-5, cv. Bil-7, cv. Bor-1, cv. Br-0, cv. Bur-0, cv.
FT C24, cv. CIBC-17, cv. Ct-1, cv. Ed-1, cv. Edi-0, cv. Fab-4,
FT cv. Fei-0, cv. Ga-0, cv. Ge-0, cv. Goettingen-22, cv.
FT Goettingen-7, cv. Gy-0, cv. HR-10, cv. Ll-0, cv. Lov-1, cv.
FT Lov-5, cv. Lz-0, cv. Mr-0, cv. Mrk-0, cv. Mt-0, cv. Mz-0,
FT cv. NFA-10, cv. NFA-8, cv. Nd-1, cv. Nok-3, cv. Omo2-1, cv.
FT Omo2-3, cv. Oy-0, cv. Pu2-23, cv. Pu2-7, cv. REN-11, cv.
FT Ra-0, cv. Se-0, cv. Sq-1, cv. Sq-8, cv. Ts-1, cv. Ts-5, cv.
FT Ull2-3, cv. Uod-1, cv. Uod-7, cv. Wa-1, cv. Wassilewskija,
FT cv. Wei-0, cv. Wt-5, cv. Zdr-1)"
FT /evidence="ECO:0000269|PubMed:17237349,
FT ECO:0000269|PubMed:20400945"
FT CONFLICT 100
FT /note="S -> F (in Ref. 3; ABV21214)"
FT /evidence="ECO:0000305"
FT CONFLICT 146..151
FT /note="SAPDGV -> NDSDGF (in Ref. 3; ABV21214)"
FT /evidence="ECO:0000305"
FT CONFLICT 456
FT /note="S -> G (in Ref. 3; ABV21214)"
FT /evidence="ECO:0000305"
FT CONFLICT 459..461
FT /note="IFF -> VFI (in Ref. 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 473..482
FT /note="IETPIVDHQL -> SETPTVDHQV (in Ref. 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 482
FT /note="L -> V (in Ref. 3; ABV21214)"
FT /evidence="ECO:0000305"
FT CONFLICT 489
FT /note="M -> K (in Ref. 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 527..528
FT /note="SN -> CT (in Ref. 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 617
FT /note="N -> S (in Ref. 3; ABV21214 and 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 626
FT /note="F -> Y (in Ref. 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 705
FT /note="F -> Y (in Ref. 3; ABV21214)"
FT /evidence="ECO:0000305"
FT CONFLICT 723..724
FT /note="SS -> CG (in Ref. 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 724
FT /note="S -> G (in Ref. 3; ABV21214)"
FT /evidence="ECO:0000305"
FT CONFLICT 762
FT /note="D -> G (in Ref. 3; ABV21214)"
FT /evidence="ECO:0000305"
FT CONFLICT 763
FT /note="S -> SL (in Ref. 1; no nucleotide entry)"
FT /evidence="ECO:0000305"
FT CONFLICT 789
FT /note="D -> E (in Ref. 3; ABV21214)"
FT /evidence="ECO:0000305"
FT CONFLICT 797
FT /note="I -> V (in Ref. 3; ABV21214 and 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 812
FT /note="A -> S (in Ref. 3; ABV21214 and 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 818..821
FT /note="ERSL -> GRSP (in Ref. 3; ABV21214 and 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 836..838
FT /note="SWT -> CWS (in Ref. 2; ABN05291)"
FT /evidence="ECO:0000305"
FT CONFLICT 848
FT /note="D -> E (in Ref. 3; ABV21214)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 850 AA; 96466 MW; 05E14F9848B46410 CRC64;
MRGLPNFYHS YTFFFFFLLI LFPAYSISAN TLSASESLTI SSNNTIVSPG NVFELGFFKP
GLDSRWYLGI WYKAISKRTY VWVANRDTPL SSSIGTLKIS DSNLVVLDQS DTPVWSTNLT
GGDVRSPLVA ELLDNGNFVL RDSKNSAPDG VLWQSFDFPT DTLLPEMKLG WDAKTGFNRF
IRSWKSPDDP SSGDFSFKLE TEGFPEIFLW NRESRMYRSG PWNGIRFSGV PEMQPFEYMV
FNFTTSKEEV TYSFRITKSD VYSRLSISSS GLLQRFTWIE TAQNWNQFWY APKDQCDEYK
ECGVYGYCDS NTSPVCNCIK GFKPRNPQVW GLRDGSDGCV RKTLLSCGGG DGFVRLKKMK
LPDTTTASVD RGIGVKECEQ KCLRDCNCTA FANTDIRGSG SGCVTWTGEL FDIRNYAKGG
QDLYVRLAAT DLEDKRNRSA KIIGSSIGVS VLLLLSFIIF FLWKRKQKRS ILIETPIVDH
QLRSRDLLMN EVVISSRRHI SRENNTDDLE LPLMEFEEVA MATNNFSNAN KLGQGGFGIV
YKGKLLDGQE MAVKRLSKTS VQGTDEFKNE VKLIARLQHI NLVRLLACCV DAGEKMLIYE
YLENLSLDSH LFDKSRNSKL NWQMRFDIIN GIARGLLYLH QDSRFRIIHR DLKASNILLD
KYMTPKISDF GMARIFGRDE TEANTRKVVG TYGYMSPEYA MDGIFSMKSD VFSFGVLLLE
IISSKRNKGF YNSDRDLNLL GCVWRNWKEG KGLEIIDPII TDSSSTFRQH EILRCIQIGL
LCVQERAEDR PTMSLVILML GSESTTIPQP KAPGYCLERS LLDTDSSSSK QRDDESWTVN
QITVSVLDAR
