SDA1_CAEEL
ID SDA1_CAEEL Reviewed; 801 AA.
AC Q9NEU2; A7UGI8; Q9NEV8;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein SDA1 homolog;
DE AltName: Full=Proximal proliferation in germline protein 3;
GN Name=pro-3; ORFNames=Y39B6A.14;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF GLY-48, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=16876152; DOI=10.1016/j.ydbio.2006.06.011;
RA Voutev R., Killian D.J., Ahn J.H., Hubbard E.J.A.;
RT "Alterations in ribosome biogenesis cause specific defects in C. elegans
RT hermaphrodite gonadogenesis.";
RL Dev. Biol. 298:45-58(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm (Probable). Required for normal somatic gonad development and
CC for regulation of germline development and proliferation.
CC {ECO:0000269|PubMed:16876152, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Worms exhibit defects in hermaphrodite
CC gonadogenesis and germline proliferation which are associated with a
CC reduction in sheath cell number. {ECO:0000269|PubMed:16876152}.
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000305}.
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DR EMBL; EU068466; ABU49431.1; -; mRNA.
DR EMBL; AL132948; CAD31812.3; -; Genomic_DNA.
DR RefSeq; NP_741684.2; NM_171594.4.
DR AlphaFoldDB; Q9NEU2; -.
DR SMR; Q9NEU2; -.
DR BioGRID; 45218; 8.
DR STRING; 6239.Y39B6A.14; -.
DR EPD; Q9NEU2; -.
DR PaxDb; Q9NEU2; -.
DR PeptideAtlas; Q9NEU2; -.
DR EnsemblMetazoa; Y39B6A.14.1; Y39B6A.14.1; WBGene00012676.
DR GeneID; 180256; -.
DR KEGG; cel:CELE_Y39B6A.14; -.
DR UCSC; Y39B6A.14; c. elegans.
DR CTD; 180256; -.
DR WormBase; Y39B6A.14; CE40630; WBGene00012676; pro-3.
DR eggNOG; KOG2229; Eukaryota.
DR GeneTree; ENSGT00390000010355; -.
DR HOGENOM; CLU_009161_3_1_1; -.
DR InParanoid; Q9NEU2; -.
DR OMA; AMYKTYK; -.
DR OrthoDB; 426305at2759; -.
DR PhylomeDB; Q9NEU2; -.
DR PRO; PR:Q9NEU2; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00012676; Expressed in embryo and 3 other tissues.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR007949; SDA1_dom.
DR InterPro; IPR012977; Uncharacterised_NUC130/133_N.
DR PANTHER; PTHR12730; PTHR12730; 1.
DR Pfam; PF08158; NUC130_3NT; 1.
DR Pfam; PF05285; SDA1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Gonadal differentiation; Nucleus;
KW Protein transport; Reference proteome; Ribosome biogenesis; Transport.
FT CHAIN 1..801
FT /note="Protein SDA1 homolog"
FT /id="PRO_0000287487"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..565
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..631
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 48
FT /note="G->E: In ar226; confers a recessive temperature-
FT sensitive Pro phenotype in which an ectopic mass of
FT proliferating germ cells occupies the proximal adult germ
FT line."
FT /evidence="ECO:0000269|PubMed:16876152"
SQ SEQUENCE 801 AA; 92131 MW; E73E9993CF779902 CRC64;
MGKVSKSPGK GEKRIGKVGK KNGKSNAPTE GSNSGKASRF TMSERNLGLM QEIIRKDPES
YKEEFLEQFN YFVQTMKLLH LQPEQSRQEM QSLVDSVLFL SGLAKHYPKE SKQFSDSLFE
LLREQGAGLD PEVRMAFCKA LVLLRNQDMI DPIILMETFF ELVKVEDKVL RKFLLSSISA
HLKRVYHKKK DVKMLGKIQN LCFSKMKDSR SIVARAAQLV CIDAFRRKFW RDARTANVIA
QACFHKVAKI QVTSMKFFLG SENENGDAED SDEMDSDAED NTKTLKEVMT SFRNVKKTRK
REKNVERAKK MISKKKKAKK EGRSKECNLM AIQSLYDPQE FVDRLFGAVE AKKMDNFEVR
LFKIALCARI IGIHRLHTLS FYSYLHRFLQ PKQRDVTKIL LYAAQACHEM VPPDTVEQLI
RVIANNFVTD RNSPEAMTVG INAIREILSN CPFAATEELL RDLSEYKTYK NKNVSMAARS
LITLFRAVNP KLLARKDRGK PQEKDDEDEE YNGFARPKVH DFISGAEILD EDAADGEQGH
LEEDGTDSEL DVSDVDTDDV DTDDDADEPV AKKKRVEQKS VENDAESDAD DEEIEDEEEM
DDEEEEIEIS DEEEEEIDDE AEEEAVVEEE ASEAVEKDPK LKASKNSMDR IMTQEDFKNI
KAYQLKKQLI GEKRLKKQMG KGRSQADERI VDEMAEKLEL KRSSDGLARL SDIEHFYKKK
RQSKEERMAD VMAGRADEDY KFGRPKKNGA HVGRTNDQNS KKKVFAMVKN KIRGRNRQRS
FRDQQKSLRH YLMRQSGRKP Q
