ID   SDA1_CHATD              Reviewed;         767 AA.
AC   G0S215;
DT   16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-MAR-2016, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Protein SDA1;
GN   Name=SDA1; ORFNames=CTHT_0015620;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC       cytoplasm. May also be required for 60S ribosomal subunit maturation
CC       and accumulation. {ECO:0000250|UniProtKB:P53313}.
CC   -!- SUBUNIT: Associated with the 60S pre-ribosomal particles.
CC       {ECO:0000250|UniProtKB:P53313}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P53313}.
CC   -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EGS23075.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; GL988039; EGS23075.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_006692067.1; XM_006692004.1.
DR   AlphaFoldDB; G0S215; -.
DR   SMR; G0S215; -.
DR   STRING; 759272.G0S215; -.
DR   EnsemblFungi; EGS23075; EGS23075; CTHT_0015620.
DR   GeneID; 18255600; -.
DR   KEGG; cthr:CTHT_0015620; -.
DR   eggNOG; KOG2229; Eukaryota.
DR   HOGENOM; CLU_009161_2_1_1; -.
DR   OrthoDB; 426305at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:InterPro.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027312; Sda1.
DR   InterPro; IPR007949; SDA1_dom.
DR   InterPro; IPR012977; Uncharacterised_NUC130/133_N.
DR   PANTHER; PTHR12730; PTHR12730; 1.
DR   Pfam; PF08158; NUC130_3NT; 1.
DR   Pfam; PF05285; SDA1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Protein transport; Reference proteome;
KW   Ribosome biogenesis; Transport.
FT   CHAIN           1..767
FT                   /note="Protein SDA1"
FT                   /id="PRO_0000435806"
FT   REGION          504..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          662..767
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..533
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..551
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..575
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        675..728
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        751..767
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   767 AA;  86808 MW;  49C8205DE98FA44A CRC64;
     MPKRKVAALE KVEADLVNLQ YKIRRDPKSY AQEFYDQWLA YDAQRQIFFS SPATASSEDI
     KKFHDLVDLV AHVADLYPDI TAPFPDHLKQ LLTQHHTTLD KDLREKVVGS LVLLRRKDVI
     DSVSLLTTLF PILISSPSKS LRTLIYTKII SDLRESNAKA TNHKLNRTIQ TVLHNLLTSD
     RTSSKGLWAC RITRELWRRQ IWTDARPCDV MKEACLSDNE KVVVGGCRFF LGGDKEREEL
     EDEESDEDID LKKVKHQSLI NKKTKKRQKA YEKALEKIKK QERKKHAPHP LNFSALHLIN
     DPQGFAEKLF QKHLQNLKNK FTLENRLLVL QLVTRLVGLH KLTVLPLYSW FVRYLTPKQL
     NVTTFLACLA QATHNLVPPD VIEPLVVKIA NEFVSEASAA EVAAAGLNAI REVAMRQPLC
     MSETLLQDLV LYQKSKDKGV MMAAKGLQSL YREVYPEMLQ KKFRGKEATM GLRAGEIKPL
     KFGEEEAAED IEGIELLEKY KEEQKKKKVE QGEGDGENKD GGEEDEDDGW NSSEWEVASD
     TSESSGGWID VSSESEDEGP AKKRQRKDSG AEEVPELVDT SKTNGEVQTN GEAKAGSEAR
     PNGTAESTAE AEARRISKLA TTTILTPADL AKLKELRQQA KLDKMLGNTA KRKKELIEKH
     IEDGLTAEDI ELPAQLGKKA TKEEKLERAR ENKPSRDEHK STQALRKAKK EAEGKSSTNK
     EKARKKNFFM TLGKAKQKQK RSLVETRKAL RAHIKRSKAG GRRRNGQ