ID   BET_FFV                 Reviewed;         387 AA.
AC   O93036; O56863;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   02-JUN-2021, entry version 48.
DE   RecName: Full=Protein Bet;
GN   Name=bet;
OS   Feline foamy virus (FFV) (Feline syncytial virus).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Spumaretrovirinae; Felispumavirus.
OX   NCBI_TaxID=53182;
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM BEL-2).
RX   PubMed=9261397; DOI=10.1128/jvi.71.9.6727-6741.1997;
RA   Winkler I., Bodem J., Haas L., Zemba M., Delius H., Flower R.,
RA   Fluegel R.M., Loechelt M.;
RT   "Characterization of the genome of feline foamy virus and its proteins
RT   shows distinct features different from those of primate Spumaviruses.";
RL   J. Virol. 71:6727-6741(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA] (ISOFORM BET).
RC   STRAIN=Isolate FUV;
RX   PubMed=9601510; DOI=10.1006/viro.1998.9113;
RA   Bodem J., Loechelt M., Delius H., Fluegel R.M.;
RT   "Detection of subgenomic cDNAs and mapping of feline foamy virus mRNAs
RT   reveals complex patterns of transcription.";
RL   Virology 244:417-426(1998).
RN   [3]
RP   FUNCTION OF BET AND BEL-2.
RC   STRAIN=Isolate FUV;
RX   PubMed=11531409; DOI=10.1006/viro.2001.1065;
RA   Alke A., Schwantes A., Kido K., Floetenmeyer M., Fluegel R.M., Loechelt M.;
RT   "The bet gene of feline foamy virus is required for virus replication.";
RL   Virology 287:310-320(2001).
RN   [4]
RP   INTERACTION WITH FELINE APOBEC3CA.
RX   PubMed=15911774; DOI=10.1073/pnas.0501445102;
RA   Loechelt M., Romen F., Bastone P., Muckenfuss H., Kirchner N., Kim Y.B.,
RA   Truyen U., Rosler U., Battenberg M., Saib A., Flory E., Cichutek K.,
RA   Muenk C.;
RT   "The antiretroviral activity of APOBEC3 is inhibited by the foamy virus
RT   accessory Bet protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:7982-7987(2005).
CC   -!- FUNCTION: May be implicated in the establishment and/or maintenance of
CC       viral persistance. Bet is required for viral replication.
CC       {ECO:0000269|PubMed:11531409}.
CC   -!- SUBUNIT: Bet interacts with host APOBEC3Ca (PubMed:15911774). This
CC       interaction does not induce APOBEC3Ca degradation but prevents its
CC       dimerization and incorporation into virion (Probable).
CC       {ECO:0000269|PubMed:15911774, ECO:0000305|PubMed:15911774}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=The first 31 residues are shared by isoforms Bet and Bel-1,
CC         the last 356 residues are shared by isoforms Bet and Bel-2.;
CC       Name=Bet;
CC         IsoId=O93036-1; Sequence=Displayed;
CC       Name=Bel-1; Synonyms=Bel1;
CC         IsoId=O56862-1; Sequence=External;
CC       Name=Bel-2; Synonyms=Bel2;
CC         IsoId=O93036-2; Sequence=VSP_019619;
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DR   EMBL; Y08851; CAA70078.1; -; Genomic_DNA.
DR   EMBL; AJ223851; CAA11584.1; -; Genomic_RNA.
DR   RefSeq; NP_056916.1; NC_001871.1.
DR   Proteomes; UP000008763; Genome.
DR   Proteomes; UP000201849; Genome.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..387
FT                   /note="Protein Bet"
FT                   /id="PRO_0000244971"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..74
FT                   /note="Missing (in isoform Bel-2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_019619"
SQ   SEQUENCE   387 AA;  44224 MW;  887C8B9EE2C1BBFE CRC64;
     MASKYPEEGP ITEGVEEDFN SHSTSGLDLT SVGKNPEHPR RILLVLQHLI AYAEATIKKQ
     DVPGPLLPIL SPYVMAWDNP QNVVTRLVNL GESWKKYLLS PGWKDCGERD LTMLTRELLV
     PGIGLVQIAA TLTKTYVLMC NGRCITGSRT DPDCDPLFCK LLCWKQNIQD PRECNLEEWC
     LYSLDPEHDP LWDPKMIVRR HRNLLPYCMR PFLIWMNYIS HNPLTQQCIM MKTLNMLWRA
     QADDPSDVAS LYPRVKVFKA SHFDIFGSAS GNSEERVSWA KENSHRGEYS LLPSSDDEEE
     EMSEREELLC HINQCQQKLF YPGGTTDVLG MESNVWLTKF VNIKFPKGTK VILPDGRKFI
     ACDPELKPLL QELKFLDRAT SESSDSE