ID   SDA1_DANRE              Reviewed;         682 AA.
AC   Q6NV26; Q8JHJ0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protein SDA1 homolog;
DE   AltName: Full=SDA1 domain-containing protein 1;
GN   Name=sdad1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12006978; DOI=10.1038/ng896;
RA   Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W.,
RA   Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M.,
RA   Hopkins N.;
RT   "Insertional mutagenesis in zebrafish rapidly identifies genes essential
RT   for early vertebrate development.";
RL   Nat. Genet. 31:135-140(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC       cytoplasm. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000305}.
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DR   EMBL; AF506206; AAM34650.1; -; mRNA.
DR   EMBL; BC068340; AAH68340.1; -; mRNA.
DR   RefSeq; NP_775337.1; NM_173230.1.
DR   AlphaFoldDB; Q6NV26; -.
DR   SMR; Q6NV26; -.
DR   STRING; 7955.ENSDARP00000090568; -.
DR   PaxDb; Q6NV26; -.
DR   PRIDE; Q6NV26; -.
DR   GeneID; 286746; -.
DR   KEGG; dre:286746; -.
DR   CTD; 55153; -.
DR   ZFIN; ZDB-GENE-021213-1; sdad1.
DR   eggNOG; KOG2229; Eukaryota.
DR   InParanoid; Q6NV26; -.
DR   OrthoDB; 426305at2759; -.
DR   PhylomeDB; Q6NV26; -.
DR   PRO; PR:Q6NV26; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027312; Sda1.
DR   InterPro; IPR007949; SDA1_dom.
DR   InterPro; IPR012977; Uncharacterised_NUC130/133_N.
DR   PANTHER; PTHR12730; PTHR12730; 1.
DR   Pfam; PF08158; NUC130_3NT; 1.
DR   Pfam; PF05285; SDA1; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Protein transport; Reference proteome;
KW   Ribosome biogenesis; Transport.
FT   CHAIN           1..682
FT                   /note="Protein SDA1 homolog"
FT                   /id="PRO_0000287485"
FT   REGION          226..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          601..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          254..319
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        485..506
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        507..541
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        601..628
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..658
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..676
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        158
FT                   /note="N -> K (in Ref. 1; AAM34650)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        294
FT                   /note="Q -> K (in Ref. 1; AAM34650)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        519
FT                   /note="D -> E (in Ref. 1; AAM34650)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   682 AA;  79022 MW;  4EB8EF43DBC9D842 CRC64;
     MSGRHNNKLP TNLPQLQNLI KRDPKSYTEE FLQQYRHYQS NVEIFKHQPD KANKDLSELV
     MFLAQVGHCY LEELSDFPQQ LTDLLLNYHT VLESDLRMTF CKALIMLRNK DLVSPTSLLG
     LFFELLRCHD KLLRKTLYTH IVTDIKNINA KHKNNKMNTT LQNFMYTMLR DSNPIAAKIS
     LDVMVELYRR NIWNDAKTVN VITTACFSKV TKILVAGLKF FLGKDEDEKK DDDSESEDEG
     STARDLMMRY STGKKTSKNK KKLEKAMKVL KKHKKKKKVE VFNFSAIHLI HDPQDFSEKL
     LKQLESSNER FEVKIMMMEL ISRLVGIHEL FLFNFYPFVQ RFLQPHQREV TKILLCAAQS
     SHQLVPPEII EPVIMTIANN FVTDRNSGEV MTVGINAIKE VVARCPLSMS EDLLQDLTQY
     KSHKDKNVVM SARGLIQLFR DLNPKMLTRK DRGRPTESSK EAKIHKYGEL EAKDYIPGAE
     VLEAEKAEDE EDEDGWESAS MSDDDEDGEW VNVHHSSDDD QAEVAEKLQS IPEEERKAKA
     AMVSTSRLLT QDDFKKIRVA QMAKEVGNAP GKGQKRKNVD SDEEERGELL SLRDIERLHK
     KPKSDKETRL ATAMAGRTDR KEFTKKRGKL NPYASTSNKE KKRKKNFMMM RHSQNVRTKG
     KRSFREKQIA LRDSLLKKRK FK