ID   SDA1_DICDI              Reviewed;         756 AA.
AC   Q55DE2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Protein SDA1 homolog;
DE   AltName: Full=SDA1 domain-containing protein 1 homolog;
GN   Name=sdad1; ORFNames=DDB_G0269688;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC       cytoplasm. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72194.1; -; Genomic_DNA.
DR   RefSeq; XP_646189.1; XM_641097.1.
DR   AlphaFoldDB; Q55DE2; -.
DR   SMR; Q55DE2; -.
DR   STRING; 44689.DDB0266533; -.
DR   PaxDb; Q55DE2; -.
DR   PRIDE; Q55DE2; -.
DR   EnsemblProtists; EAL72194; EAL72194; DDB_G0269688.
DR   GeneID; 8617142; -.
DR   KEGG; ddi:DDB_G0269688; -.
DR   dictyBase; DDB_G0269688; sdad1.
DR   eggNOG; KOG2229; Eukaryota.
DR   HOGENOM; CLU_009161_3_1_1; -.
DR   InParanoid; Q55DE2; -.
DR   OMA; AMYKTYK; -.
DR   PhylomeDB; Q55DE2; -.
DR   PRO; PR:Q55DE2; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027312; Sda1.
DR   InterPro; IPR007949; SDA1_dom.
DR   InterPro; IPR012977; Uncharacterised_NUC130/133_N.
DR   PANTHER; PTHR12730; PTHR12730; 2.
DR   Pfam; PF08158; NUC130_3NT; 1.
DR   Pfam; PF05285; SDA1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Protein transport; Reference proteome;
KW   Ribosome biogenesis; Transport.
FT   CHAIN           1..756
FT                   /note="Protein SDA1 homolog"
FT                   /id="PRO_0000328429"
FT   REGION          494..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          638..756
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          227..282
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        495..518
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..594
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..615
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        655..709
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   756 AA;  88003 MW;  8FC43FD4E0977FFA CRC64;
     MGTRILDLLQ LQNLTKRDPS AYKEEFLLQY QHYLTQLQIF QLKPTKEFKH FSQLVSYLSH
     VCVCYPKELS EFPKQISDLL ENNCNNLEPE LRRILAKSLI LMRNRNLLPQ IQMLSLFFKL
     FRVHDKPLRS LLYSHIVADI KNTNLKQKNQ KLNRTLQNFM FTMMNDDSEI ASKMSLKVMI
     ELFRKKIWHD TKTVNVISNG VFSKNSKILI TTLNFFLHID NPDKPDEEEE DEAVKEKRAK
     DNFRKKSLAH RVGKKTKGRI TRLAKSKVDL KKAKQEEDNK LQPNFPAIEL IHDPQGYCDK
     LFNVLVKTTE KFETRIMIMN FISRLIYVHK LMVYNFYPFL QKYLQPHQKN ITYLLAVLAQ
     SCHELVDPDV LKPLVMTIAK YFVNDGCGSD VIAIGLNTIR SICSRCPLAI DTVLLADLIQ
     YREKKEKGVA MASKSLLQFF KDNYPSMLPK KERGKNKTDI GLLAFGHQKV SQGIDGLDLL
     MDEELNARLD AIEAGEEFES DDDSDSDSDD EGWEDVNTTT ADDDNNSEWV SDDDDEEGEE
     DEEVEDEEDE EEVDEEELED DEEGDWESGE EIEGDDDDDE EWEEVEEEVE EEEEEEIKPT
     KKKSQQKEKV EVLRTDDIKV LTDEELIRIR KLRILKEARE NNKQYEDMDQ DDDENGENVH
     GLIRPEDLQG AHKKKKEEKL ERIARAKEGR DGGYGSKASR RDKTGKSTTN EYKAKVTKPF
     VLTLKTKKVR GKSLKSFRDK QIGQREHSAR QKRGRH