SDA1_MOUSE
ID SDA1_MOUSE Reviewed; 687 AA.
AC Q80UZ2; Q3TP91; Q3TUN3; Q8CDL7; Q99JQ4;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein SDA1 homolog;
DE AltName: Full=SDA1 domain-containing protein 1;
GN Name=Sdad1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-641 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Lung, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-585, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-585, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-585 AND SER-589, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q80UZ2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80UZ2-2; Sequence=VSP_025508;
CC Name=3;
CC IsoId=Q80UZ2-3; Sequence=VSP_025506, VSP_025507;
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000305}.
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DR EMBL; AK029881; BAC26657.1; -; mRNA.
DR EMBL; AK160646; BAE35938.1; -; mRNA.
DR EMBL; AK164608; BAE37846.1; -; mRNA.
DR EMBL; BC005751; AAH05751.1; -; mRNA.
DR EMBL; BC042708; AAH42708.1; -; mRNA.
DR CCDS; CCDS19429.1; -. [Q80UZ2-1]
DR RefSeq; NP_766301.1; NM_172713.2.
DR AlphaFoldDB; Q80UZ2; -.
DR SMR; Q80UZ2; -.
DR BioGRID; 231123; 39.
DR STRING; 10090.ENSMUSP00000031364; -.
DR iPTMnet; Q80UZ2; -.
DR PhosphoSitePlus; Q80UZ2; -.
DR EPD; Q80UZ2; -.
DR jPOST; Q80UZ2; -.
DR MaxQB; Q80UZ2; -.
DR PaxDb; Q80UZ2; -.
DR PeptideAtlas; Q80UZ2; -.
DR PRIDE; Q80UZ2; -.
DR ProteomicsDB; 255503; -. [Q80UZ2-1]
DR ProteomicsDB; 255504; -. [Q80UZ2-2]
DR ProteomicsDB; 255505; -. [Q80UZ2-3]
DR GeneID; 231452; -.
DR KEGG; mmu:231452; -.
DR UCSC; uc008yct.1; mouse. [Q80UZ2-1]
DR UCSC; uc008ycu.1; mouse. [Q80UZ2-3]
DR UCSC; uc012dyp.1; mouse. [Q80UZ2-2]
DR CTD; 55153; -.
DR MGI; MGI:2140779; Sdad1.
DR eggNOG; KOG2229; Eukaryota.
DR InParanoid; Q80UZ2; -.
DR OrthoDB; 426305at2759; -.
DR PhylomeDB; Q80UZ2; -.
DR TreeFam; TF105727; -.
DR BioGRID-ORCS; 231452; 25 hits in 71 CRISPR screens.
DR PRO; PR:Q80UZ2; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q80UZ2; protein.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEP:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR007949; SDA1_dom.
DR InterPro; IPR012977; Uncharacterised_NUC130/133_N.
DR PANTHER; PTHR12730; PTHR12730; 1.
DR Pfam; PF08158; NUC130_3NT; 1.
DR Pfam; PF05285; SDA1; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Nucleus; Phosphoprotein;
KW Protein transport; Reference proteome; Ribosome biogenesis; Transport.
FT CHAIN 1..687
FT /note="Protein SDA1 homolog"
FT /id="PRO_0000287483"
FT REGION 484..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 254..315
FT /evidence="ECO:0000255"
FT COMPBIAS 486..509
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
FT MOD_RES 234
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
FT MOD_RES 236
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
FT MOD_RES 552
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
FT MOD_RES 585
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 589
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 595
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVU7"
FT VAR_SEQ 238..239
FT /note="DD -> VG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025506"
FT VAR_SEQ 240..687
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025507"
FT VAR_SEQ 271
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025508"
FT CONFLICT 238
FT /note="D -> E (in Ref. 1; BAC26657/BAE35938)"
FT /evidence="ECO:0000305"
FT CONFLICT 488
FT /note="E -> D (in Ref. 1; BAC26657/BAE35938)"
FT /evidence="ECO:0000305"
FT CONFLICT 664
FT /note="S -> T (in Ref. 1; BAC26657)"
FT /evidence="ECO:0000305"
FT CONFLICT 670
FT /note="D -> E (in Ref. 1; BAC26657)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 687 AA; 79559 MW; BC2B308F178DAFF7 CRC64;
MSGRNNNKLP SNLPQLQNLI KRDPPAYVEE FLQQYNHYKS NMEIFKLQPN KPSKELAELV
MFMAQIGQCY PEHLSNFPQE LKDLLSYNHT VLDPDLRMTF CKALILLRNK NLINPSSLLE
LFFELLRCHD KLLRKTLYTH IVTDIKNINA KHKNNKVNVV LQNFMYTMLR DSNATAAKMS
LDVMIELYRR NIWNDAKTVN VITTACFSKI TKILVAALTF FLGKDEEEKQ DSDSESEDDG
PTARDLLVQY ATGKKGSKNK KKLEKAMKVL KKQKKKKKPE VFNFSAIHLI HDPQDFAEKL
LKQLESCKER FEVKMMLMNL ISRLVGIHEL FLFNFYPFVQ RFLQPHQREV TKILLFAAQA
SHHLVPPEII QSLLVTVANN FVTDKNSGEV MTVGINAIKE ITARCPLAMT EELLQDLAQY
KTHKDKNVMM SARTLIHLFR TLNPQMLQKK FRGKPTEASI EARIQEYGEL DAKDYIPGAE
VLELEKGENT EDDEDGWESA SLSEEEEEDG EWVDVHHSSD EEQQAIATKL DSMPMEERKA
KAAAISTSRV LTQDDFQKIR MAQMKKEMDA APGKAQKRKY LEIDSDEESR GELLSLRDIE
RLHKKPKSDK ETRLATAMAG RTDRKEFVRK KTKINPFSSS TNKEKKKQKN FMMMRYSQNV
RSKSARSFRD KQLALRDALL KKRKRMK
