SDA1_SCHPO
ID SDA1_SCHPO Reviewed; 719 AA.
AC Q10342; Q9URU8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein sda1;
GN Name=sda1; ORFNames=SPBC106.14c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm. May also be required for 60S ribosomal subunit maturation
CC and accumulation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB53730.1; -; Genomic_DNA.
DR PIR; T39271; T39271.
DR RefSeq; NP_595163.1; NM_001021072.2.
DR AlphaFoldDB; Q10342; -.
DR SMR; Q10342; -.
DR BioGRID; 276435; 4.
DR STRING; 4896.SPBC106.14c.1; -.
DR iPTMnet; Q10342; -.
DR MaxQB; Q10342; -.
DR PaxDb; Q10342; -.
DR PRIDE; Q10342; -.
DR EnsemblFungi; SPBC106.14c.1; SPBC106.14c.1:pep; SPBC106.14c.
DR GeneID; 2539889; -.
DR KEGG; spo:SPBC106.14c; -.
DR PomBase; SPBC106.14c; sda1.
DR VEuPathDB; FungiDB:SPBC106.14c; -.
DR eggNOG; KOG2229; Eukaryota.
DR HOGENOM; CLU_009161_2_1_1; -.
DR InParanoid; Q10342; -.
DR OMA; AMYKTYK; -.
DR PhylomeDB; Q10342; -.
DR PRO; PR:Q10342; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISO:PomBase.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; ISO:PomBase.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR007949; SDA1_dom.
DR InterPro; IPR012977; Uncharacterised_NUC130/133_N.
DR PANTHER; PTHR12730; PTHR12730; 1.
DR Pfam; PF08158; NUC130_3NT; 1.
DR Pfam; PF05285; SDA1; 2.
PE 3: Inferred from homology;
KW Nucleus; Protein transport; Reference proteome; Ribosome biogenesis;
KW Transport.
FT CHAIN 1..719
FT /note="Protein sda1"
FT /id="PRO_0000116515"
FT REGION 515..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..559
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 81250 MW; 93864D55B86BD1D6 CRC64;
MVKRRTAAVL PNNLPHLQHL VKKDPKSYRE EFLQQWNHYE TAREIFLVNP SSDISEFCSL
IDFISQTCNY YHDVTADFPS ELIELLQKNH TIFPFELCEK IVLCLVLLKN KTVISPITLL
QCFFPLFREN PTRGVRELLY QQVSLTIRNA NKQAKNDKLN KAVQSALFTL VDGSGSGSAT
HTDYSGQKRE YSASELSGVW AVKMVRDLWK RNVWSGDARA VNIMKSAALS SNPKVMLAGI
YFFLGADNQE EEEESDDEGP DVSKLLHQAN VNKKTKSREA ALLRARAVVK KKERGKQNVP
TNVNFPALQL LHDPQGFAEE LFEKHLASSK SRLSMDQKLV VLRLLTRLVG SHKLTVLGLY
SFLMKYLTPH QRDVTQFLAC LAQASHEFVP PDALEPLVRK IADEFVTSGV ANEVVCAGIN
AIREVCARAP LAMTPDLLQD LTEYKSSKDK GVMMASRSLI TLYREVAPDM LKRKDRGKLA
SIEMKDRTPL KYGEELNVTH GIQGLELLAQ YKAEHGEEGE NGDDWDNWEV SEDGQNSDDS
GGWIDVDSDD NIELSDSDEE EEKATARKES DEKGSSSQKE LVDRMTELAS QSILTPNDLK
KLEELREQAG VDRLVNGPKR SLKRPDDAVE ADEIEGPRKK AKNDREARIA SVMEGREGRD
KFSSKKAGFN PTSLSNKRKQ RNKNFMMIKH KLKGKAGRSL VQKQKVLREH VAREKRKIK
