ID   SDA1_XENLA              Reviewed;         689 AA.
AC   Q2VPG3; Q4V844; Q6IP54; Q7ZXR8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Protein SDA1 homolog;
DE   AltName: Full=SDA1 domain-containing protein 1;
GN   Name=sdad1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC       cytoplasm. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000305}.
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DR   EMBL; BC044283; AAH44283.1; ALT_TERM; mRNA.
DR   EMBL; BC070991; AAH70991.1; ALT_TERM; mRNA.
DR   EMBL; BC072064; AAH72064.1; ALT_TERM; mRNA.
DR   EMBL; BC097552; AAH97552.1; ALT_TERM; mRNA.
DR   EMBL; BC108827; AAI08828.1; -; mRNA.
DR   RefSeq; NP_001082492.1; NM_001089023.1.
DR   RefSeq; XP_018089948.1; XM_018234459.1.
DR   RefSeq; XP_018089951.1; XM_018234462.1.
DR   RefSeq; XP_018089957.1; XM_018234468.1.
DR   AlphaFoldDB; Q2VPG3; -.
DR   SMR; Q2VPG3; -.
DR   BioGRID; 99838; 2.
DR   IntAct; Q2VPG3; 1.
DR   MaxQB; Q2VPG3; -.
DR   PRIDE; Q2VPG3; -.
DR   DNASU; 398506; -.
DR   GeneID; 398506; -.
DR   KEGG; xla:398506; -.
DR   CTD; 398506; -.
DR   Xenbase; XB-GENE-1008737; sdad1.S.
DR   OrthoDB; 426305at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 398506; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:InterPro.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027312; Sda1.
DR   InterPro; IPR007949; SDA1_dom.
DR   InterPro; IPR012977; Uncharacterised_NUC130/133_N.
DR   PANTHER; PTHR12730; PTHR12730; 1.
DR   Pfam; PF08158; NUC130_3NT; 1.
DR   Pfam; PF05285; SDA1; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Protein transport; Reference proteome;
KW   Ribosome biogenesis; Transport.
FT   CHAIN           1..689
FT                   /note="Protein SDA1 homolog"
FT                   /id="PRO_0000287486"
FT   REGION          227..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          623..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          258..319
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        227..244
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..509
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        623..652
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   689 AA;  80077 MW;  4DFEB94B8B6CCB6D CRC64;
     MSGRNNNKLP TNLPQLQNLI KRDPASYREE FLQQYKHYLS VIEIFKLQPD KPNKDLSTLV
     MFMAQTAHCF QQYLEDFPEQ LKSLLCTHHT VMDPDQRMTL CKALIMLRNK NLISPSVLLE
     LFFELLRCQD KLLRKTLYTH IVTDIKNINA KHKNNKVNTT LQNFMYTMLR DNNAIAAKIS
     LDVMIELYRR NIWNDAKTVN VITTACFSKV TKILVAALKF FLGKDEDEKK DSDSESEDEG
     PTARDLMVRY STGKKNTKNK KKLDKAMKVL KKHKKKKRPE VFNFSAIHLV HDPQEFAEKL
     LKQLEASKER FEVKLMHMDL ISRLVGIHEL FLFNFYPFVQ RFLQPHQREV TKILLYAAQA
     THHLVPPEIS QSVLKTIANN FVTDRNSGEV MTVGINAIKE VTARCPLAMT EELLQDLAQY
     KTHRDKNVSM SARGLIQLFR SLNPDMLQKK FRGKPTEASK EARIHAYGEL DAKDYIPGAE
     VLEVEQEKKE EPEEDDGWES ASLSDDDEDG EWIDVHHSSD EEQQEMAEKI QAMPTEERIA
     KAATVSGSRL LTQEDFKKIR LAQLAKEMNN APGKSMKRKN IEIDSDEEER SGELLSLRDI
     EHLHKKPKSD KETRLATVLA GRTDRKEFVR KKTKMNPHAS STNKEKKKNK NFMMMRYSQN
     IRSKKKRSFR DKQIALRDSL LKKRKRLMK