SDAC_ECO57
ID SDAC_ECO57 Reviewed; 429 AA.
AC P0AAD7; P36559;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Serine transporter SdaC {ECO:0000250|UniProtKB:P0AAD6};
DE AltName: Full=H(+)/L-serine symporter {ECO:0000250|UniProtKB:P0AAD6};
GN Name=sdaC; OrderedLocusNames=Z4113, ECs3656;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Mediates the import of L-serine into the cell. Is energized
CC by proton cotransport. {ECO:0000250|UniProtKB:P0AAD6}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out);
CC Xref=Rhea:RHEA:28887, ChEBI:CHEBI:15378, ChEBI:CHEBI:33384;
CC Evidence={ECO:0000250|UniProtKB:P0AAD6};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28889;
CC Evidence={ECO:0000250|UniProtKB:P0AAD6};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0AAD6}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC SdaC/TdcC subfamily. {ECO:0000305}.
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DR EMBL; AE005174; AAG57910.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB37079.1; -; Genomic_DNA.
DR PIR; B85931; B85931.
DR PIR; H91085; H91085.
DR RefSeq; NP_311683.1; NC_002695.1.
DR RefSeq; WP_000450476.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P0AAD7; -.
DR STRING; 155864.EDL933_3977; -.
DR EnsemblBacteria; AAG57910; AAG57910; Z4113.
DR EnsemblBacteria; BAB37079; BAB37079; ECs_3656.
DR GeneID; 66673337; -.
DR GeneID; 916539; -.
DR KEGG; ece:Z4113; -.
DR KEGG; ecs:ECs_3656; -.
DR PATRIC; fig|386585.9.peg.3822; -.
DR eggNOG; COG0814; Bacteria.
DR HOGENOM; CLU_052043_1_1_6; -.
DR OMA; PLTYLGH; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR004694; Hydroxy_aa_transpt.
DR TIGRFAMs; TIGR00814; stp; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..429
FT /note="Serine transporter SdaC"
FT /id="PRO_0000093809"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..46
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..140
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..163
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..201
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..297
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..429
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 429 AA; 46906 MW; F97AB93F84A38FE6 CRC64;
METTQTSTIA SKDSRSAWRK TDTMWMLGLY GTAIGAGVLF LPINAGVGGM IPLIIMAILA
FPMTFFAHRG LTRFVLSGKN PGEDITEVVE EHFGIGAGKL ITLLYFFAIY PILLVYSVAI
TNTVESFMSH QLGMTPPPRA ILSLILIVGM MTIVRFGEQM IVKAMSILVF PFVGVLMLLA
LYLIPQWNGA ALETLSLDTA SATGNGLWMT LWLAIPVMVF SFNHSPIISS FAVAKREEYG
DMAEQKCSKI LAFAHIMMVL TVMFFVFSCV LSLTPADLAA AKEQNISILS YLANHFNAPV
IAWMAPIIAI IAITKSFLGH YLGAREGFNG MVIKSLRGKG KSIEINKLNR ITALFMLVTT
WIVATLNPSI LGMIETLGGP IIAMILFLMP MYAIQKVPAM RKYSGHISNV FVVVMGLIAI
SAIFYSLFS
