SDAC_HAEIN
ID SDAC_HAEIN Reviewed; 412 AA.
AC P44615;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Serine transporter SdaC {ECO:0000250|UniProtKB:P0AAD6};
DE AltName: Full=H(+)/L-serine symporter {ECO:0000250|UniProtKB:P0AAD6};
GN Name=sdaC; OrderedLocusNames=HI_0289;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Mediates the import of L-serine into the cell. Is energized
CC by proton cotransport. {ECO:0000250|UniProtKB:P0AAD6}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out);
CC Xref=Rhea:RHEA:28887, ChEBI:CHEBI:15378, ChEBI:CHEBI:33384;
CC Evidence={ECO:0000250|UniProtKB:P0AAD6};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28889;
CC Evidence={ECO:0000250|UniProtKB:P0AAD6};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0AAD6}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC SdaC/TdcC subfamily. {ECO:0000305}.
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DR EMBL; L42023; AAC21954.1; -; Genomic_DNA.
DR PIR; G64059; G64059.
DR RefSeq; NP_438456.1; NC_000907.1.
DR RefSeq; WP_005666700.1; NC_000907.1.
DR AlphaFoldDB; P44615; -.
DR STRING; 71421.HI_0289; -.
DR EnsemblBacteria; AAC21954; AAC21954; HI_0289.
DR KEGG; hin:HI_0289; -.
DR PATRIC; fig|71421.8.peg.305; -.
DR eggNOG; COG0814; Bacteria.
DR HOGENOM; CLU_052043_1_1_6; -.
DR OMA; PLTYLGH; -.
DR PhylomeDB; P44615; -.
DR BioCyc; HINF71421:G1GJ1-307-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR018227; Amino_acid_transport_2.
DR InterPro; IPR004694; Hydroxy_aa_transpt.
DR Pfam; PF03222; Trp_Tyr_perm; 1.
DR TIGRFAMs; TIGR00814; stp; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..412
FT /note="Serine transporter SdaC"
FT /id="PRO_0000093810"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 412 AA; 45895 MW; 147C1DA2E9099008 CRC64;
MKSTEKLKWN KFDATWMLNL FGTAVGAGVL FLPINAGMGG FWPLVLMAII VGPMTYFAHR
GLAYFVLSSK NPGSDITEVV EEHFGKTAGK LITLLYFFAI FPILLIYGNG ITNTVDSFIV
NQLGMASPNR VILSFVLIAV LISVMLFNEK VMLKITEWLV YPLVLILFVL SIYLIPEWNS
AVLYEFPTVG GFLTTLWLTI PVLVFSFNHS PAISSFTCSQ FREYKTFDGA ERHISHTEKG
ASTILLFFVM FFVFSCVLTL TPEELVAAKE QNISILSFLA NKFDNPYISY FGPLVAFLAI
TSSFFGHYMG AREGLEGLYL KMKGEAVNRK KLNYATALFF LLTLWGVAII NPSILGLIES
LGGPIIAMIL FIMPMYAIRK IPAMKRYSGR FSNVFVTIMG LIAISAVVYG LL
