ID   BET_SFVCP               Reviewed;         490 AA.
AC   Q87043;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   29-SEP-2021, entry version 66.
DE   RecName: Full=Protein Bet;
GN   Name=bet;
OS   Simian foamy virus (isolate chimpanzee) (SFVcpz).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Spumaretrovirinae; Spumavirus.
OX   NCBI_TaxID=298339;
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8184531; DOI=10.1006/viro.1994.1285;
RA   Herchenroder O., Renne R., Loncar D., Cobb E.K., Murthy K.K., Schneider J.,
RA   Mergia A., Luciw P.A.;
RT   "Isolation, cloning, and sequencing of simian foamy viruses from
RT   chimpanzees (SFVcpz): high homology to human foamy virus (HFV).";
RL   Virology 201:187-199(1994).
CC   -!- FUNCTION: Bet counteracts the innate antiretroviral activity of APOBEC3
CC       family defense factors by inhibiting their incorporation into virions.
CC       May be implicated in the establishment and/or maintenance of viral
CC       persistance. Bet is required for viral replication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Bet interacts with host APOBEC3C; this interaction does not
CC       induce APOBEC3C degradation, but prevents dimerization and
CC       incorporation into virion of the latter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Isoform Bet]: Host cytoplasm
CC       {ECO:0000250|UniProtKB:P89873}. Host nucleus
CC       {ECO:0000250|UniProtKB:P89873}. Secreted
CC       {ECO:0000250|UniProtKB:P89873}. Note=Bet is highly expressed in
CC       infected cells, where it localizes to both cytoplasm and nucleus. Also
CC       secreted and internalized by non-infected surrounding cells.
CC       {ECO:0000250|UniProtKB:P89873}.
CC   -!- SUBCELLULAR LOCATION: [Isoform Bel-2]: Host nucleus
CC       {ECO:0000250|UniProtKB:P89873}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=The first 88 residues are shared by isoform Bel-1 and isoform
CC         Bet.;
CC       Name=Bet;
CC         IsoId=Q87043-1; Sequence=Displayed;
CC       Name=Bel-1; Synonyms=Bel1;
CC         IsoId=Q87042-1; Sequence=External;
CC       Name=Bel-2; Synonyms=Bel2;
CC         IsoId=Q87043-2; Sequence=VSP_037602;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA19981.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; U04327; AAA19981.1; ALT_SEQ; Genomic_DNA.
DR   SMR; Q87043; -.
DR   Proteomes; UP000001063; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR004956; Foamy_BEL.
DR   Pfam; PF03274; Foamy_BEL; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Reference proteome; Secreted.
FT   CHAIN           1..490
FT                   /note="Protein Bet"
FT                   /id="PRO_0000378599"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          25..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          471..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..126
FT                   /note="Missing (in isoform Bel-2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_037602"
SQ   SEQUENCE   490 AA;  56208 MW;  C5202E5CB0AD84A1 CRC64;
     MDSYQEEEPV ASTSGLQDLQ TLSELVGPEN AGEGDLVIAE EPEENPRRPR RYTKRDVKCV
     SYHAYKELED KHPHHIKLQD WIPKPEEMVA QKVQNQDVGT ILSFDVTCLK SITSLGRNDP
     GNDPSIMSHV LPVVTPWPMS QDHYAPTLFG LLDRYYKGYL ENPATFQTWK FTCQEDPSGK
     RYMGTQFWVP PLGQVNIQFY KNYQIVTCCQ ALDPFANIFH GTEEEMYDID SGPDVWCTPS
     LCFKVIYEGA IGQKQEQKSW LCRLGYGHRM GANDYRRVDL YAMKQGKKNP YGDKGDAALQ
     YAYQVKRGCK AGCLASPVLN FKALQFHRTL MADLTNPKIG QGYLAHGYHA AMEAYGPQRG
     SSEERVWWNA TRNQGKKDEY YREGGEEPHY PNTPAPHKKT WEERHKVLKL SPFATPSDIQ
     RWTTRALPYG WKVIDGNGDD YTSRRNIRTL TEMTQEEIRK RWERGYCDPF IDSGSDSDGP
     LSKPQTVKVW