SDC1_SCHPO
ID SDC1_SCHPO Reviewed; 109 AA.
AC O74861;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Set1 complex component sdc1;
DE Short=Set1C component sdc1;
DE AltName: Full=COMPASS component sdc1;
DE AltName: Full=Complex proteins associated with set1 protein sdc1;
DE AltName: Full=Lid2 complex component sdc1;
DE Short=Lid2C component sdc1;
GN Name=sdc1; ORFNames=SPCC18.11c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA21425.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP FUNCTION OF THE SET1 COMPLEX, AND COMPOSITION OF THE SET1 AND LID2
RP COMPLEXES.
RX PubMed=12488447; DOI=10.1074/jbc.m209562200;
RA Roguev A., Schaft D., Shevchenko A., Aasland R., Shevchenko A.,
RA Stewart A.F.;
RT "High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation
RT in budding and fission yeasts.";
RL J. Biol. Chem. 278:8487-8493(2003).
RN [3] {ECO:0000305}
RP COMPOSITION OF THE SET1 AND LID2 COMPLEXES.
RX PubMed=14617822; DOI=10.1074/mcp.m300081-mcp200;
RA Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F.,
RA Shevchenko A.;
RT "A comparative analysis of an orthologous proteomic environment in the
RT yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.";
RL Mol. Cell. Proteomics 3:125-132(2004).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: The COMPASS (Set1C) complex specifically mono-, di- and
CC trimethylates histone H3 to form H3K4me1/2/3, which subsequently
CC activates gene expression by regulating transcription elongation and
CC plays a role in telomere length maintenance.
CC {ECO:0000269|PubMed:12488447}.
CC -!- SUBUNIT: Component of the COMPASS (Set1C) complex composed of ash2,
CC sdc1, set1, shg1, spp1, swd1, swd2 and swd3. Component of the Lid2
CC complex composed of ash2, jmj3, lid2, sdc1 and snt2.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the dpy-30 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329672; CAA21425.1; -; Genomic_DNA.
DR PIR; T41154; T41154.
DR RefSeq; NP_588390.1; NM_001023381.2.
DR AlphaFoldDB; O74861; -.
DR SMR; O74861; -.
DR BioGRID; 275717; 131.
DR STRING; 4896.SPCC18.11c.1; -.
DR iPTMnet; O74861; -.
DR MaxQB; O74861; -.
DR PaxDb; O74861; -.
DR EnsemblFungi; SPCC18.11c.1; SPCC18.11c.1:pep; SPCC18.11c.
DR GeneID; 2539145; -.
DR KEGG; spo:SPCC18.11c; -.
DR PomBase; SPCC18.11c; sdc1.
DR VEuPathDB; FungiDB:SPCC18.11c; -.
DR eggNOG; KOG4109; Eukaryota.
DR HOGENOM; CLU_2224732_0_0_1; -.
DR InParanoid; O74861; -.
DR PhylomeDB; O74861; -.
DR PRO; PR:O74861; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000785; C:chromatin; IC:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0048189; C:Lid2 complex; IDA:PomBase.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IDA:PomBase.
DR GO; GO:0031507; P:heterochromatin assembly; IC:PomBase.
DR GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR InterPro; IPR007858; Dpy-30_motif.
DR InterPro; IPR037856; Sdc1/DPY30.
DR PANTHER; PTHR23356; PTHR23356; 1.
DR Pfam; PF05186; Dpy-30; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome.
FT CHAIN 1..109
FT /note="Set1 complex component sdc1"
FT /id="PRO_0000114685"
FT REGION 49..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 109 AA; 11856 MW; E42AD16BA3AD323F CRC64;
MSNSAPARQY LNEKVTPVLL EGMKILARDR PENPLQFLGQ FLLDANANQQ KQKEIVNQPE
PQQETPKADA DMSTPTMAEQ VQTSFSNPAS TPLTQTSSPS SNPGKNSAS
