SDC4_CHICK
ID SDC4_CHICK Reviewed; 197 AA.
AC P49416;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Syndecan-4;
DE Flags: Precursor;
GN Name=SDC4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8276871; DOI=10.1016/s0021-9258(17)42405-7;
RA Baciu P.C., Acaster C., Goetinck P.F.;
RT "Molecular cloning and genomic organization of chicken syndecan-4.";
RL J. Biol. Chem. 269:696-703(1994).
RN [2]
RP INTERACTION WITH SDOS.
RC TISSUE=Embryo;
RX PubMed=10633082; DOI=10.1242/jcs.113.2.315;
RA Baciu P.C., Saoncella S., Lee S.H., Denhez F., Leuthardt D., Goetinck P.F.;
RT "Syndesmos, a protein that interacts with the cytoplasmic domain of
RT syndecan-4, mediates cell spreading and actin cytoskeletal organization.";
RL J. Cell Sci. 113:315-324(2000).
CC -!- FUNCTION: Cell surface proteoglycan that bears heparan sulfate.
CC Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
CC {ECO:0000250|UniProtKB:P31431}.
CC -!- SUBUNIT: Interacts with SDOS. {ECO:0000269|PubMed:10633082}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the syndecan proteoglycan family. {ECO:0000305}.
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DR EMBL; L23940; AAA16479.1; -; Unassigned_DNA.
DR PIR; A53126; A53126.
DR RefSeq; NP_001007870.1; NM_001007869.1.
DR AlphaFoldDB; P49416; -.
DR BMRB; P49416; -.
DR SMR; P49416; -.
DR STRING; 9031.ENSGALP00000006255; -.
DR PaxDb; P49416; -.
DR Ensembl; ENSGALT00000093118; ENSGALP00000070840; ENSGALG00000003932.
DR GeneID; 419184; -.
DR KEGG; gga:419184; -.
DR CTD; 6385; -.
DR VEuPathDB; HostDB:geneid_419184; -.
DR eggNOG; ENOG502S1SZ; Eukaryota.
DR GeneTree; ENSGT00940000160663; -.
DR HOGENOM; CLU_046599_3_0_1; -.
DR InParanoid; P49416; -.
DR OMA; GSWVPTE; -.
DR OrthoDB; 1507361at2759; -.
DR PhylomeDB; P49416; -.
DR TreeFam; TF320463; -.
DR Reactome; R-GGA-1971475; A tetrasaccharide linker sequence is required for GAG synthesis.
DR Reactome; R-GGA-2022928; HS-GAG biosynthesis.
DR Reactome; R-GGA-2024096; HS-GAG degradation.
DR Reactome; R-GGA-3000170; Syndecan interactions.
DR PRO; PR:P49416; -.
DR Proteomes; UP000000539; Chromosome 20.
DR Bgee; ENSGALG00000003932; Expressed in colon and 13 other tissues.
DR ExpressionAtlas; P49416; baseline and differential.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0090630; P:activation of GTPase activity; ISS:AgBase.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:1902725; P:negative regulation of satellite cell differentiation; ISS:AgBase.
DR GO; GO:1902723; P:negative regulation of skeletal muscle satellite cell proliferation; ISS:AgBase.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISS:AgBase.
DR GO; GO:0061098; P:positive regulation of protein tyrosine kinase activity; ISS:AgBase.
DR GO; GO:1903076; P:regulation of protein localization to plasma membrane; ISS:AgBase.
DR GO; GO:1902766; P:skeletal muscle satellite cell migration; ISS:AgBase.
DR GO; GO:0044319; P:wound healing, spreading of cells; ISS:AgBase.
DR InterPro; IPR003585; Neurexin-like.
DR InterPro; IPR001050; Syndecan.
DR InterPro; IPR027789; Syndecan/Neurexin_dom.
DR InterPro; IPR030479; Syndecan_CS.
DR PANTHER; PTHR10915; PTHR10915; 1.
DR Pfam; PF01034; Syndecan; 1.
DR SMART; SM00294; 4.1m; 1.
DR PROSITE; PS00964; SYNDECAN; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Heparan sulfate; Membrane; Proteoglycan; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..197
FT /note="Syndecan-4"
FT /id="PRO_0000033510"
FT TOPO_DOM 20..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="O-linked (Xyl...) (heparan sulfate) serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 65
FT /note="O-linked (Xyl...) (heparan sulfate) serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 67
FT /note="O-linked (Xyl...) (heparan sulfate) serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 197 AA; 21502 MW; 88F1C7E188A99848 CRC64;
MPLPRAAFLL GLLLAAAAAE SVRETETMDA RWLDNVGSGD LPDDEDIGEF TPHLTSDEFD
IDDTSGSGDY SDYDDAIYLT TVDTPAISDN YIPGDTERKM EGEKKNTMLD NEIIPDKASP
VEANLSNKIS MASTANSSIF ERTEVLTALI AGGAVGLLFA VFLILLLVYR MKKKDEGSYD
LGKKPIYKKA PTNEFYA
