ID   ABDA_MANSE              Reviewed;          97 AA.
AC   Q26430;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Homeobox protein abdominal-A homolog;
DE   Flags: Fragment;
GN   Name=ABD-A;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1685112; DOI=10.1242/dev.112.1.119;
RA   Nagy L.M., Booker R., Riddiford L.M.;
RT   "Isolation and embryonic expression of an abdominal-A-like gene from the
RT   lepidopteran, Manduca sexta.";
RL   Development 112:119-129(1991).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Required for
CC       segmental identity of the first through tenth abdominal segments.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; S77989; AAB21131.2; ALT_SEQ; Genomic_DNA.
DR   PIR; A60127; A60127.
DR   AlphaFoldDB; Q26430; -.
DR   SMR; Q26430; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022132; Abdominal-A.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF12407; Abdominal-A; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..>97
FT                   /note="Homeobox protein abdominal-A homolog"
FT                   /id="PRO_0000200252"
FT   DNA_BIND        6..65
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          73..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         97
SQ   SEQUENCE   97 AA;  12197 MW;  91C567E7C2CE8F6A CRC64;
     SNGCPRRRGR QTYTRFQTLE LEKEFHFNHY LTRRRRIEIA HALCLTERQI KIWFQNRRMK
     LKKELRAVKE INEQARRERE EQDRMKQQQQ EKQAKLE