ID   BEV1E_BETPN             Reviewed;         160 AA.
AC   P43178;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Major pollen allergen Bet v 1-E;
DE   AltName: Full=Allergen Bet v I-E;
DE   AltName: Allergen=Bet v 1-E;
GN   Name=BETV1E;
OS   Betula pendula (European white birch) (Betula verrucosa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fagales; Betulaceae; Betula.
OX   NCBI_TaxID=3505;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Pollen;
RX   PubMed=7852325; DOI=10.1074/jbc.270.6.2607;
RA   Swoboda I., Jilek A., Ferreira F., Engel E., Hoffman-Sommergruber K.,
RA   Scheiner O., Kraft D., Breiteneder H., Pittenauer E., Schmid E.,
RA   Vicente O., Heberle-Bors E., Ahorn H., Breitenbach M.;
RT   "Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid
RT   chromatography, mass spectrometry, and cDNA cloning.";
RL   J. Biol. Chem. 270:2607-2613(1995).
CC   -!- FUNCTION: May be a general steroid carrier protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Is a cause of type I
CC       allergic reactions in Europe, North America and USSR.
CC   -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
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DR   EMBL; X77267; CAA54483.1; -; mRNA.
DR   PIR; D55699; D55699.
DR   AlphaFoldDB; P43178; -.
DR   SMR; P43178; -.
DR   Allergome; 89; Bet v 1.
DR   Allergome; 97; Bet v 1.0103.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR000916; Bet_v_I/MLP.
DR   InterPro; IPR024949; Bet_v_I_allergen.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF00407; Bet_v_1; 1.
DR   PRINTS; PR00634; BETALLERGEN.
DR   SMART; SM01037; Bet_v_1; 1.
DR   PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE   1: Evidence at protein level;
KW   Allergen; Cytoplasm; Direct protein sequencing;
KW   Pathogenesis-related protein; Plant defense.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..160
FT                   /note="Major pollen allergen Bet v 1-E"
FT                   /id="PRO_0000154178"
FT   BINDING         55
FT                   /ligand="brassinolide"
FT                   /ligand_id="ChEBI:CHEBI:28277"
FT                   /evidence="ECO:0000250|UniProtKB:P43185"
FT   BINDING         82
FT                   /ligand="brassinolide"
FT                   /ligand_id="ChEBI:CHEBI:28277"
FT                   /evidence="ECO:0000250|UniProtKB:P43185"
FT   BINDING         84
FT                   /ligand="brassinolide"
FT                   /ligand_id="ChEBI:CHEBI:28277"
FT                   /evidence="ECO:0000250|UniProtKB:P43185"
FT   BINDING         101
FT                   /ligand="brassinolide"
FT                   /ligand_id="ChEBI:CHEBI:28277"
FT                   /evidence="ECO:0000250|UniProtKB:P43185"
SQ   SEQUENCE   160 AA;  17448 MW;  C120E54A1DB139AE CRC64;
     MGVFNYETEA TSVIPAARLF KAFILDGDNL FPKVAPQAIS SVENIEGNGG PGTIKKISFP
     EGIPFKYVKG RVDEVDHTNF KYSYSVIEGG PVGDTLEKIS NEIKIVATPN GGSILKINNK
     YHTKGDHEVK AEQIKASKEM GETLLRAVES YLLAHSDAYN