ID   SDCS_STAAN              Reviewed;         520 AA.
AC   Q7A4P8;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Sodium-dependent dicarboxylate transporter SdcS;
DE   AltName: Full=Na(+)/dicarboxylate symporter;
GN   Name=sdcS; OrderedLocusNames=SA1732;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=N315;
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT   aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- FUNCTION: Mediates the transport of the dicarboxylates fumarate,
CC       malate, and succinate across the cytoplasmic membrane via a Na(+)-
CC       electrochemical gradient. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC       NADC subfamily. {ECO:0000305}.
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DR   EMBL; BA000018; BAB43002.1; -; Genomic_DNA.
DR   PIR; C89980; C89980.
DR   RefSeq; WP_000323161.1; NC_002745.2.
DR   AlphaFoldDB; Q7A4P8; -.
DR   SMR; Q7A4P8; -.
DR   EnsemblBacteria; BAB43002; BAB43002; BAB43002.
DR   KEGG; sau:SA1732; -.
DR   HOGENOM; CLU_005170_0_0_9; -.
DR   OMA; LHGMNTY; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001898; SLC13A/DASS.
DR   Pfam; PF00939; Na_sulph_symp; 1.
DR   TIGRFAMs; TIGR00785; dass; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Ion transport; Membrane; Sodium; Sodium transport; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..520
FT                   /note="Sodium-dependent dicarboxylate transporter SdcS"
FT                   /id="PRO_0000260097"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        452..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        491..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   520 AA;  57172 MW;  77F87F2B1B1C404A CRC64;
     MAYFNQHQSM ISKRYLTFFS KSKKKKPFSA GQLIGLILGP LLFLLTLLFF HPQDLPWKGV
     YVLAITLWIA TWWITEAIPI AATSLLPIVL LPLGHILTPE QVSSEYGNDI IFLFLGGFIL
     AIAMERWNLH TRVALTIINL IGASTSKILL GFMVATGFLS MFVSNTAAVM IMIPIGLAII
     KEAHDLQEAN TNQTSIQKFE KSLVLAIGYA GTIGGLGTLI GTPPLIILKG QYMQHFGHEI
     SFAKWMIVGI PTVIVLLGIT WLYLRYVAFR HDLKYLPGGQ TLIKQKLDEL GKMKYEEKVV
     QTIFVLASLL WITREFLLKK WEVTSSVADG TIAIFISILL FIIPAKNTEK HRRIIDWEVA
     KELPWGVLIL FGGGLALAKG ISESGLAKWL GEQLKSLNGV SPILIVIVIT IFVLFLTEVT
     SNTATATMIL PILATLSVAV GVHPLLLMAP AAMAANCAYM LPVGTPPNAI IFGSGKISIK
     QMASVGFWVN LISAIIIILV VYYVMPIVLG IDINQPLPLK