ID   SDCS_STAS1              Reviewed;         519 AA.
AC   Q49YW0;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Sodium-dependent dicarboxylate transporter SdcS;
DE   AltName: Full=Na(+)/dicarboxylate symporter;
GN   Name=sdcS; OrderedLocusNames=SSP0875;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Mediates the transport of dicarboxylates across the
CC       cytoplasmic membrane via a Na(+)-electrochemical gradient.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC       NADC subfamily. {ECO:0000305}.
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DR   EMBL; AP008934; BAE18020.1; -; Genomic_DNA.
DR   RefSeq; WP_011302754.1; NZ_MTGA01000031.1.
DR   AlphaFoldDB; Q49YW0; -.
DR   SMR; Q49YW0; -.
DR   STRING; 342451.SSP0875; -.
DR   EnsemblBacteria; BAE18020; BAE18020; SSP0875.
DR   KEGG; ssp:SSP0875; -.
DR   PATRIC; fig|342451.11.peg.874; -.
DR   eggNOG; COG0471; Bacteria.
DR   HOGENOM; CLU_005170_0_0_9; -.
DR   OMA; LHGMNTY; -.
DR   OrthoDB; 626718at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001898; SLC13A/DASS.
DR   Pfam; PF00939; Na_sulph_symp; 1.
DR   TIGRFAMs; TIGR00785; dass; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..519
FT                   /note="Sodium-dependent dicarboxylate transporter SdcS"
FT                   /id="PRO_0000260100"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        490..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   519 AA;  56978 MW;  E956E16138B6D756 CRC64;
     MNNLNKGDMR RSQYLMFFSN KKENKSYNVG QLVGLILGPL LFVLTLLLFQ PDNLSDKGVF
     VLAITLWIAT WWITEAIPIA ATSLLPLILL PVGHVLNPEE VSAQYGNDII FLFLGGFILA
     IAMERWNLHT RVALRIINTL GTSTGRILLG FMIATGFLSM FVSNTAAVMI MIPIGLAIIK
     EANELKHGDT KPESISKFEQ ALVLAIGYAG TIGGLGTLIG TPPLIILKGQ YQSAFGEEIS
     FAKWMIIGVP TVIVLLFLVW IYIRYIAFKH DMKTLPGGQD LIRKKLSELG KMKYEEKVVL
     IVFLLASFLW ITREFLLKHW TFTSEVADGT IAMFISVLLF LIPAKNKEKH KRIIDWEVAK
     DLPWGVLILF GGGLALAKGI SESGLANWLG EQLKLIEGVS PLVIVLVITI FVLFLTEITS
     NTATATMILP ILATLSVAVN VHPLLLMVPA AMAANCAYML PVGTPPNAIV FGTGKISIKK
     MASVGFWVNL LSIVVIVLVV YFLVPPVLGI DVTQPLPLK