SDD1_YEAST
ID SDD1_YEAST Reviewed; 233 AA.
AC P39983; D3DLJ3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Uncharacterized protein YEL057C;
DE AltName: Full=Suppressor of degenerative death {ECO:0000312|SGD:S000000783};
GN Name=SDD1 {ECO:0000312|SGD:S000000783};
GN OrderedLocusNames=YEL057C {ECO:0000312|SGD:S000000783};
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4] {ECO:0007744|PDB:6SNT}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.8 ANGSTROMS) OF 197-210 IN COMPLEX WITH
RP STALLED RIBOSOME, FUNCTION, AND MUTAGENESIS OF ASP-200; TYR-201; LEU-202;
RP ILE-203; PHE-204; ARG-207; 209-LYS-ARG-210; LYS-209; 210-ARG-ARG-211;
RP ARG-210; ARG-211; 212-LYS-LYS-213 AND LYS-212.
RX PubMed=32203490; DOI=10.1038/s41594-020-0393-9;
RA Matsuo Y., Tesina P., Nakajima S., Mizuno M., Endo A., Buschauer R.,
RA Cheng J., Shounai O., Ikeuchi K., Saeki Y., Becker T., Beckmann R.,
RA Inada T.;
RT "RQT complex dissociates ribosomes collided on endogenous RQC substrate
RT SDD1.";
RL Nat. Struct. Mol. Biol. 27:323-332(2020).
CC -!- FUNCTION: Acts as a endogenous target of the ribosome quality control
CC (RQC) pathway (PubMed:32203490). During translation, the nascent chain
CC has a propensity to stall ribosomes, thereby stimulating activation of
CC the RQC pathway (PubMed:32203490). {ECO:0000269|PubMed:32203490}.
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DR EMBL; U18795; AAB65030.1; -; Genomic_DNA.
DR EMBL; AY557813; AAS56139.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07597.1; -; Genomic_DNA.
DR PIR; S50532; S50532.
DR RefSeq; NP_010857.1; NM_001178872.1.
DR PDB; 6SNT; EM; 2.80 A; NC=1-233.
DR PDBsum; 6SNT; -.
DR AlphaFoldDB; P39983; -.
DR BioGRID; 36672; 164.
DR DIP; DIP-4882N; -.
DR MINT; P39983; -.
DR STRING; 4932.YEL057C; -.
DR PaxDb; P39983; -.
DR PRIDE; P39983; -.
DR EnsemblFungi; YEL057C_mRNA; YEL057C; YEL057C.
DR GeneID; 856653; -.
DR KEGG; sce:YEL057C; -.
DR SGD; S000000783; YEL057C.
DR VEuPathDB; FungiDB:YEL057C; -.
DR HOGENOM; CLU_103875_0_0_1; -.
DR OMA; KTVQFSA; -.
DR BioCyc; YEAST:G3O-30175-MON; -.
DR PRO; PR:P39983; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P39983; protein.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..233
FT /note="Uncharacterized protein YEL057C"
FT /id="PRO_0000202604"
FT REGION 196..212
FT /note="The nascent chain stimulates ribosomal stalling
FT during translation by interfering with the conformation of
FT the peptidyl transferase center (PTC), and the translating
FT mRNA by adopting a difficult-to-decode structure at the
FT ribosome decoding center"
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 200
FT /note="D->A,E,R,Y: Decreases propensity to stall
FT ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 201
FT /note="Y->A: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 202
FT /note="L->A: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 203
FT /note="I->A: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 204
FT /note="F->A: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 207
FT /note="R->A: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 209..210
FT /note="KR->AA: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 209
FT /note="K->A: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 210..211
FT /note="RR->KK: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 210
FT /note="R->A: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 211
FT /note="R->A: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 212..213
FT /note="KK->AA: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
FT MUTAGEN 212
FT /note="K->A: Decreases propensity to stall ribosomes."
FT /evidence="ECO:0000269|PubMed:32203490"
SQ SEQUENCE 233 AA; 27229 MW; B10F223BD8121537 CRC64;
MANDGIQRND NRKGFKTVQF SAYSKEIDVI MKKISFLERN ITQQLDTLPH FPKTLPPNHK
DCVSRKHRAR RGWSSQLKNL LGIYSKEEIF TLDNLAATLH DQVLKLQATL FPNAILKQVH
LDNANIENKR ILKEITYKYL SNENCKEENK FGTFIVKRIF FGDLSLGVSV LINRIAFESA
TSSIMVVRSS FIESDFFYED YLIFDCRAKR RKKLKRKILF ISTTMNFNYQ TKV
