ID   SDE5_ARATH              Reviewed;         490 AA.
AC   Q9LUQ3; Q9M7X0;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Putative nuclear RNA export factor SDE5 {ECO:0000305};
DE   AltName: Full=Protein SILENCING DEFECTIVE 5 {ECO:0000303|PubMed:17397509};
GN   Name=SDE5 {ECO:0000303|PubMed:17397509};
GN   OrderedLocusNames=At3g15390 {ECO:0000312|Araport:AT3G15390};
GN   ORFNames=MJK13.5 {ECO:0000312|EMBL:AAF35405.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17397509; DOI=10.1111/j.1365-313x.2007.03043.x;
RA   Hernandez-Pinzon I., Yelina N.E., Schwach F., Studholme D.J., Baulcombe D.,
RA   Dalmay T.;
RT   "SDE5, the putative homologue of a human mRNA export factor, is required
RT   for transgene silencing and accumulation of trans-acting endogenous
RT   siRNA.";
RL   Plant J. 50:140-148(2007).
RN   [5]
RP   FUNCTION.
RX   PubMed=20798330; DOI=10.1105/tpc.110.076638;
RA   Jauvion V., Elmayan T., Vaucheret H.;
RT   "The conserved RNA trafficking proteins HPR1 and TEX1 are involved in the
RT   production of endogenous and exogenous small interfering RNA in
RT   Arabidopsis.";
RL   Plant Cell 22:2697-2709(2010).
CC   -!- FUNCTION: Involved in sense transgene post-transcriptional gene
CC       silencing (S-PTGS). Not involved in repeat-induced transgene silencing
CC       (IR-PTGS). Essential component of the trans-acting short interfering
CC       RNA (tasiRNA) pathway. Required for the production of tasiRNAs
CC       (PubMed:17397509, PubMed:20798330). Acts together with RDR6 in
CC       generating double-stranded RNA from specific single-stranded RNAs. May
CC       be involved in the transport of RNA molecules that are converted into a
CC       double-stranded form by RDR6. Involved in virus-induced silencing. Not
CC       involved in the biogenesis of microRNAs and 24 nt siRNAs produced by
CC       DCL3 (PubMed:17397509). {ECO:0000269|PubMed:17397509,
CC       ECO:0000269|PubMed:20798330}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST data.
CC         {ECO:0000305};
CC       Name=1;
CC         IsoId=Q9LUQ3-1; Sequence=Displayed;
CC   -!- DISRUPTION PHENOTYPE: Elongated and curled downward leaves. Upon
CC       infection, over-accumulation of cucumber mosaic virus (CMV) RNA and
CC       enhanced susceptibility to CMV. {ECO:0000269|PubMed:17397509}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF35405.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB022218; BAB02368.1; -; Genomic_DNA.
DR   EMBL; AC024081; AAF35405.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE75662.1; -; Genomic_DNA.
DR   RefSeq; NP_188158.4; NM_112407.5. [Q9LUQ3-1]
DR   AlphaFoldDB; Q9LUQ3; -.
DR   SMR; Q9LUQ3; -.
DR   STRING; 3702.AT3G15390.1; -.
DR   PaxDb; Q9LUQ3; -.
DR   PRIDE; Q9LUQ3; -.
DR   ProteomicsDB; 232889; -. [Q9LUQ3-1]
DR   EnsemblPlants; AT3G15390.1; AT3G15390.1; AT3G15390. [Q9LUQ3-1]
DR   GeneID; 820778; -.
DR   Gramene; AT3G15390.1; AT3G15390.1; AT3G15390. [Q9LUQ3-1]
DR   KEGG; ath:AT3G15390; -.
DR   Araport; AT3G15390; -.
DR   TAIR; locus:2090181; AT3G15390.
DR   eggNOG; KOG2401; Eukaryota.
DR   HOGENOM; CLU_024477_1_0_1; -.
DR   InParanoid; Q9LUQ3; -.
DR   OMA; MASAYCQ; -.
DR   OrthoDB; 1111822at2759; -.
DR   PhylomeDB; Q9LUQ3; -.
DR   PRO; PR:Q9LUQ3; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LUQ3; baseline and differential.
DR   Genevisible; Q9LUQ3; AT.
DR   GO; GO:0005829; C:cytosol; HDA:TAIR.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0010267; P:ta-siRNA processing; TAS:TAIR.
DR   InterPro; IPR013899; DUF1771.
DR   Pfam; PF08590; DUF1771; 1.
DR   SMART; SM01162; DUF1771; 1.
PE   4: Predicted;
KW   Alternative splicing; Plant defense; Reference proteome;
KW   RNA-mediated gene silencing.
FT   CHAIN           1..490
FT                   /note="Putative nuclear RNA export factor SDE5"
FT                   /id="PRO_0000434564"
SQ   SEQUENCE   490 AA;  55162 MW;  942CFB3FB27712DD CRC64;
     MSKIASSSNS DPDSRSLQVL LDTFGSRFSL DDIAAAYCQA SQNVDVAGEI LSAMAEKTPQ
     CDQVEMKTAT SKPTQVYVPK EVPRQEDSKA KVWRPKRNSI SNGTVSSVIG KEYARTRPIS
     NAPKEATKPL KINSRDIPET EIWSEEMRKS NEGKISRAPT DVEEFIVKML GEGFQASQEV
     IHQVLGVCGY DVKKSTEKLL DFSDTKKYAD VGISNEVMSK VDPQRQSTSC NQMELQKISQ
     SVGARTFTGS QEGRNAKNGL EKEVLEALFS GAERYVDKPK VTRHFGERRP GVAGRPVFKP
     LEDPFQERVV AVKQSSNTSK EDDDENEFKA HRKAVREHLN QMKEYYGAAA EAFSKGETER
     AHRLVEKGHF FGQKAREADD KSVAKMIDVN QEDDSTYEED EVVTVNMNEH EAKEALRLLK
     RQLIYFSGIS SFKYLRVQLG EKKEDFKSKR KHIVKLLEGE SIPWTEEDGG LVIMIRVDEI
     DPKKLSFAKK