ID   SDF2A_DROSI             Reviewed;         163 AA.
AC   B4QFP7;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Succinate dehydrogenase assembly factor 2-A, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03057};
DE            Short=SDH assembly factor 2-A {ECO:0000255|HAMAP-Rule:MF_03057};
DE            Short=SDHAF2-A {ECO:0000255|HAMAP-Rule:MF_03057};
DE   Flags: Precursor;
GN   ORFNames=GD10178;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Plays an essential role in the assembly of succinate
CC       dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC       complex II) that is a component of both the tricarboxylic acid (TCA)
CC       cycle and the mitochondrial electron transport chain, and which couples
CC       the oxidation of succinate to fumarate with the reduction of ubiquinone
CC       (coenzyme Q) to ubiquinol. Required for flavinylation (covalent
CC       attachment of FAD) of the flavoprotein subunit of the SDH catalytic
CC       dimer. {ECO:0000255|HAMAP-Rule:MF_03057}.
CC   -!- SUBUNIT: Interacts with the flavoprotein subunit within the SDH
CC       catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-
CC       Rule:MF_03057}.
CC   -!- SIMILARITY: Belongs to the SDHAF2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03057}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM000362; EDX06153.1; -; Genomic_DNA.
DR   RefSeq; XP_002080568.1; XM_002080532.2.
DR   AlphaFoldDB; B4QFP7; -.
DR   SMR; B4QFP7; -.
DR   STRING; 7240.B4QFP7; -.
DR   EnsemblMetazoa; FBtr0210088; FBpp0208580; FBgn0181953.
DR   GeneID; 6733513; -.
DR   HOGENOM; CLU_103054_0_1_1; -.
DR   OMA; YGKPQNP; -.
DR   PhylomeDB; B4QFP7; -.
DR   Proteomes; UP000000304; Chromosome 2r.
DR   Bgee; FBgn0181953; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0055070; P:copper ion homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0018293; P:protein-FAD linkage; ISS:UniProtKB.
DR   Gene3D; 1.10.150.250; -; 1.
DR   HAMAP; MF_03057; SDHAF2; 1.
DR   InterPro; IPR005631; SDH.
DR   InterPro; IPR036714; SDH_sf.
DR   InterPro; IPR028882; SDHAF2.
DR   Pfam; PF03937; Sdh5; 1.
DR   SUPFAM; SSF109910; SSF109910; 1.
PE   3: Inferred from homology;
KW   Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..23
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03057"
FT   CHAIN           24..163
FT                   /note="Succinate dehydrogenase assembly factor 2-A,
FT                   mitochondrial"
FT                   /id="PRO_0000383177"
SQ   SEQUENCE   163 AA;  19153 MW;  F95E854C37DCB13D CRC64;
     MLRQLRLTMD ISGWIFLPWR RSMSNMKDSP PPPPPLASTF DDVIVDYEDP DYLPLPEYPV
     RPNEPLETRK QRLLYQSRKR GMLENDLLLS TFAAKHLQNF SAEQTAQYDQ LINGVSNDWD
     IYYWATEVKP TPKEYDTEIM GLLKEHVKNA ERVTRLRQPD LNA