SDF2L_MOUSE
ID SDF2L_MOUSE Reviewed; 221 AA.
AC Q9ESP1; Q9ESP2;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Stromal cell-derived factor 2-like protein 1;
DE Short=SDF2-like protein 1;
DE Flags: Precursor;
GN Name=Sdf2l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=11162531; DOI=10.1006/bbrc.2000.4111;
RA Fukuda S., Sumii M., Masuda Y., Takahashi M., Koike N., Teishima J.,
RA Yasumoto H., Itamoto T., Asahara T., Dohi K., Kamiya K.;
RT "Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene
RT and encodes a new member of the Pmt/rt protein family.";
RL Biochem. Biophys. Res. Commun. 280:407-414(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-
CC ProRule:PRU10138}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with high expression in the
CC testis, ovary, uterus, and low expression in heart and skeletal muscle.
CC -!- INDUCTION: By tunicamycin and a calcium ionophore, A23187.
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DR EMBL; AB043006; BAB18276.1; -; mRNA.
DR EMBL; AB043008; BAB18278.1; -; Genomic_DNA.
DR EMBL; BC053425; AAH53425.1; -; mRNA.
DR CCDS; CCDS37270.1; -.
DR RefSeq; NP_071719.1; NM_022324.3.
DR AlphaFoldDB; Q9ESP1; -.
DR SMR; Q9ESP1; -.
DR BioGRID; 211030; 21.
DR CORUM; Q9ESP1; -.
DR STRING; 10090.ENSMUSP00000023453; -.
DR PhosphoSitePlus; Q9ESP1; -.
DR REPRODUCTION-2DPAGE; Q9ESP1; -.
DR EPD; Q9ESP1; -.
DR jPOST; Q9ESP1; -.
DR MaxQB; Q9ESP1; -.
DR PaxDb; Q9ESP1; -.
DR PeptideAtlas; Q9ESP1; -.
DR PRIDE; Q9ESP1; -.
DR ProteomicsDB; 256725; -.
DR TopDownProteomics; Q9ESP1; -.
DR Antibodypedia; 217; 99 antibodies from 19 providers.
DR DNASU; 64136; -.
DR Ensembl; ENSMUST00000023453; ENSMUSP00000023453; ENSMUSG00000022769.
DR GeneID; 64136; -.
DR KEGG; mmu:64136; -.
DR UCSC; uc007ykc.2; mouse.
DR CTD; 23753; -.
DR MGI; MGI:2149842; Sdf2l1.
DR VEuPathDB; HostDB:ENSMUSG00000022769; -.
DR eggNOG; KOG3358; Eukaryota.
DR GeneTree; ENSGT00940000160018; -.
DR HOGENOM; CLU_078126_1_0_1; -.
DR InParanoid; Q9ESP1; -.
DR OMA; KPQHGTR; -.
DR OrthoDB; 1534407at2759; -.
DR PhylomeDB; Q9ESP1; -.
DR TreeFam; TF314557; -.
DR BioGRID-ORCS; 64136; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Sdf2l1; mouse.
DR PRO; PR:Q9ESP1; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9ESP1; protein.
DR Bgee; ENSMUSG00000022769; Expressed in spermatocyte and 218 other tissues.
DR Genevisible; Q9ESP1; MM.
DR GO; GO:0101031; C:chaperone complex; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISA:MGI.
DR GO; GO:0034663; C:endoplasmic reticulum chaperone complex; IDA:ParkinsonsUK-UCL.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0051117; F:ATPase binding; ISO:MGI.
DR GO; GO:0051087; F:chaperone binding; ISO:MGI.
DR GO; GO:0051787; F:misfolded protein binding; ISO:MGI.
DR GO; GO:0071218; P:cellular response to misfolded protein; ISO:MGI.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; ISO:MGI.
DR GO; GO:0071712; P:ER-associated misfolded protein catabolic process; ISO:MGI.
DR GO; GO:0042981; P:regulation of apoptotic process; ISO:MGI.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; ISO:MGI.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR Pfam; PF02815; MIR; 1.
DR SMART; SM00472; MIR; 3.
DR SUPFAM; SSF82109; SSF82109; 1.
DR PROSITE; PS00014; ER_TARGET; 1.
DR PROSITE; PS50919; MIR; 3.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Phosphoprotein; Reference proteome; Repeat; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..221
FT /note="Stromal cell-derived factor 2-like protein 1"
FT /id="PRO_0000031958"
FT DOMAIN 33..87
FT /note="MIR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00131"
FT DOMAIN 95..150
FT /note="MIR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00131"
FT DOMAIN 151..205
FT /note="MIR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00131"
FT MOTIF 218..221
FT /note="Prevents secretion from ER"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10138"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HCN8"
SQ SEQUENCE 221 AA; 23648 MW; D2A7C15D360EB25D CRC64;
MWGASRGRVA GPTLLGLLLA LSVRSGGASK ASAGLVTCGS VLKLLNTHHK VRLHSHDIKY
GSGSGQQSVT GVEESDDANS YWRIRGGSEG GCPRGLPVRC GQAVRLTHVL TGKNLHTHHF
PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS GQHWEREASV RFQHVGTSVF LSVTGEQYGN
PIRGQHEVHG MPSANAHNTW KAMEGIFIKP GADLSTGHDE L
