SDF2_MOUSE
ID SDF2_MOUSE Reviewed; 211 AA.
AC Q9DCT5; P97307;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=Stromal cell-derived factor 2;
DE Short=SDF-2;
DE Flags: Precursor;
GN Name=Sdf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8918255; DOI=10.1016/0378-1119(96)00251-x;
RA Hamada T., Tashiro K., Tada H., Inazawa J., Shirozu M., Shibahara K.,
RA Nakamura T., Martina N., Nakano T., Honjo T.;
RT "Isolation and characterization of a novel secretory protein, stromal cell-
RT derived factor-2 (SDF-2) using the signal sequence trap method.";
RL Gene 176:211-214(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with highest expression in
CC liver and kidney.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB22144.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D50646; BAA09313.1; -; mRNA.
DR EMBL; AK002496; BAB22144.2; ALT_INIT; mRNA.
DR EMBL; BC058798; AAH58798.1; -; mRNA.
DR PIR; JC5105; JC5105.
DR RefSeq; NP_033169.3; NM_009143.3.
DR AlphaFoldDB; Q9DCT5; -.
DR SMR; Q9DCT5; -.
DR BioGRID; 203139; 12.
DR STRING; 10090.ENSMUSP00000002133; -.
DR PhosphoSitePlus; Q9DCT5; -.
DR EPD; Q9DCT5; -.
DR MaxQB; Q9DCT5; -.
DR PaxDb; Q9DCT5; -.
DR PeptideAtlas; Q9DCT5; -.
DR PRIDE; Q9DCT5; -.
DR ProteomicsDB; 253431; -.
DR DNASU; 20316; -.
DR GeneID; 20316; -.
DR KEGG; mmu:20316; -.
DR UCSC; uc007kiq.2; mouse.
DR CTD; 6388; -.
DR MGI; MGI:108019; Sdf2.
DR eggNOG; KOG3358; Eukaryota.
DR InParanoid; Q9DCT5; -.
DR OrthoDB; 1534407at2759; -.
DR PhylomeDB; Q9DCT5; -.
DR TreeFam; TF314557; -.
DR BioGRID-ORCS; 20316; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Sdf2; mouse.
DR PRO; PR:Q9DCT5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9DCT5; protein.
DR GO; GO:0101031; C:chaperone complex; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0051787; F:misfolded protein binding; ISO:MGI.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; ISO:MGI.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR Pfam; PF02815; MIR; 1.
DR SMART; SM00472; MIR; 3.
DR SUPFAM; SSF82109; SSF82109; 1.
DR PROSITE; PS50919; MIR; 3.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..211
FT /note="Stromal cell-derived factor 2"
FT /id="PRO_0000031956"
FT DOMAIN 21..75
FT /note="MIR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00131"
FT DOMAIN 83..138
FT /note="MIR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00131"
FT DOMAIN 139..193
FT /note="MIR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00131"
FT CONFLICT 120
FT /note="A -> S (in Ref. 1; BAA09313)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="N -> I (in Ref. 1; BAA09313)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="K -> Q (in Ref. 1; BAA09313)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 211 AA; 23159 MW; 9BC16CB12A79DCF5 CRC64;
MAVLSLLLLG GLWSAVGASN MAVVTCGSVV KLLNTRHNVR LHSHDVRYGS GSGQQSVTGV
TSVDDSNSYW RIRGKTATVC ERGTPIKCGQ PIRLTHINTG RNLHSHHFTS PLSGNQEVSA
FGEEGEGDYL DDWTVLCNGP YWVRDGEVRF KHSSTDVLLS VTGEQYGRPI SGQKEVHGMA
QPSQNNYWKA MEGIFMKPSE LLRAEVHHAE L
