ID   BEX1_MACFA              Reviewed;         128 AA.
AC   Q2PG52;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Protein BEX1;
DE   AltName: Full=Brain-expressed X-linked protein 1 homolog;
GN   Name=BEX1; ORFNames=QbsB-11523;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain stem;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling.
CC       Plays a role in cell cycle progression and neuronal differentiation.
CC       Inhibits neuronal differentiation in response to nerve growth factor
CC       (NGF). May act as a link between the cell cycle and neurotrophic factor
CC       signaling, possibly by functioning as an upstream modulator of receptor
CC       signaling, coordinating biological responses to external signals with
CC       internal cellular states (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with neurotrophin receptor p75NTR/NGFR. Interacts
CC       with OMP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the
CC       cytoplasm and the nucleus. {ECO:0000250}.
CC   -!- PTM: Phosphorylated. Phosphorylation of Ser-105 protects it from the
CC       proteasome (By similarity). {ECO:0000250}.
CC   -!- PTM: Ubiquitinated. Degraded by the proteasome (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BEX family. {ECO:0000305}.
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DR   EMBL; AB220385; BAE72918.1; -; mRNA.
DR   RefSeq; NP_001274563.1; NM_001287634.1.
DR   AlphaFoldDB; Q2PG52; -.
DR   STRING; 9541.XP_005594263.1; -.
DR   Ensembl; ENSMFAT00000057060; ENSMFAP00000012284; ENSMFAG00000023283.
DR   GeneID; 102145923; -.
DR   CTD; 55859; -.
DR   VEuPathDB; HostDB:ENSMFAG00000023283; -.
DR   eggNOG; ENOG502RW3Y; Eukaryota.
DR   GeneTree; ENSGT00940000153412; -.
DR   OMA; AKCPGGA; -.
DR   OrthoDB; 1532209at2759; -.
DR   Proteomes; UP000233100; Chromosome X.
DR   Bgee; ENSMFAG00000023283; Expressed in pituitary gland and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   InterPro; IPR007623; BEX.
DR   InterPro; IPR021156; TF_A-like/BEX.
DR   PANTHER; PTHR19430; PTHR19430; 1.
DR   Pfam; PF04538; BEX; 1.
DR   PIRSF; PIRSF008633; BEX; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Neurogenesis; Nucleus;
KW   Phosphoprotein; Reference proteome; Ubl conjugation.
FT   CHAIN           1..128
FT                   /note="Protein BEX1"
FT                   /id="PRO_0000229773"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..32
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         105
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3MKQ2"
SQ   SEQUENCE   128 AA;  15303 MW;  A3F1862339D1B0D6 CRC64;
     MESKEKRAVN NLSMENTNQE NEEKEEKEQV ANKGEPLALP LDAGEYCVPR GNRRRFRVRQ
     PILQYRWDMM HRLGEPQARM REENMERIGE EVRQLMEKLR EKQLSHSLRA VSTDPPHHDH
     HDEFCLMP