ID   SDHA_LATSK              Reviewed;         209 AA.
AC   Q48838;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Probable L-serine dehydratase, alpha chain;
DE            Short=SDH;
DE            EC=4.3.1.17;
DE   AltName: Full=L-serine deaminase;
DE            Short=L-SD;
DE   Flags: Fragment;
GN   Name=sdhA;
OS   Latilactobacillus sakei (Lactobacillus sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=1599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 532.92 / 0-1;
RA   van den Berg D.J.C., Toonen M.Y., Robijn G.W., Kamerling J.P.,
RA   Vliegenthart J.F.G., van der Swaluw C.D.M., Ledoboer A.M., Verrips C.T.;
RT   "Isolation, characterization, and disruption of the putative
RT   exopolysaccharide gene cluster from Lactobactillus sake 0-1.";
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the iron-sulfur dependent L-serine dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; X98238; CAA66890.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q48838; -.
DR   SMR; Q48838; -.
DR   UniPathway; UPA00138; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005130; Ser_deHydtase-like_asu.
DR   InterPro; IPR004642; Ser_deHydtase_asu.
DR   Pfam; PF03313; SDH_alpha; 1.
DR   TIGRFAMs; TIGR00718; sda_alpha; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding.
FT   CHAIN           <1..209
FT                   /note="Probable L-serine dehydratase, alpha chain"
FT                   /id="PRO_0000171914"
FT   NON_TER         1
SQ   SEQUENCE   209 AA;  20887 MW;  D180E92BD55670BF CRC64;
     DIMLEAVQNA IATNEVNASM GIICATPTAG SAGTLPGILS VITKQLSLDR DAQIRFLFCA
     SAFGMVVAND AMIAGATGGC QAEVGSASAM GAAAAVEAAG GTHQQSSEAF AMAMSNLLGL
     VCDPVAGLVE VPCVKRNVIG SVNALTSADM ALAGLVSKIP ADEVISAMKS IGENLPSTLR
     ETGLGGLAAT PTGIALKMQI FGQDMSIDK