BEX2_MOUSE
ID BEX2_MOUSE Reviewed; 129 AA.
AC Q9WTZ8;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein BEX2;
DE AltName: Full=Brain-expressed X-linked protein 2 homolog;
GN Name=Bex2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=10072429; DOI=10.1093/hmg/8.4.611;
RA Brown A.L., Kay G.F.;
RT "Bex1, a gene with increased expression in parthenogenetic embryos, is a
RT member of a novel gene family on the mouse X chromosome.";
RL Hum. Mol. Genet. 8:611-619(1999).
RN [2]
RP ERRATUM OF PUBMED:10072429.
RA Brown A.L., Kay G.F.;
RL Hum. Mol. Genet. 8:943-943(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH OMP.
RX PubMed=12911636; DOI=10.1046/j.1471-4159.2003.01940.x;
RA Behrens M., Margolis J.W., Margolis F.L.;
RT "Identification of members of the Bex gene family as olfactory marker
RT protein (OMP) binding partners.";
RL J. Neurochem. 86:1289-1296(2003).
RN [6]
RP INTERACTION WITH OMP.
RX PubMed=15198671; DOI=10.1111/j.1471-4159.2004.02463.x;
RA Koo J.H., Gill S., Pannell L.K., Menco B.P.M., Margolis J.W.,
RA Margolis F.L.;
RT "The interaction of Bex and OMP reveals a dimer of OMP with a short half-
RT life.";
RL J. Neurochem. 90:102-116(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=15861462; DOI=10.1002/cne.20486;
RA Koo J.H., Saraswati M., Margolis F.L.;
RT "Immunolocalization of Bex protein in the mouse brain and olfactory
RT system.";
RL J. Comp. Neurol. 487:1-14(2005).
RN [8]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-51, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Regulator of mitochondrial apoptosis and G1 cell cycle.
CC Regulates the level of PP2A regulatory subunit B and PP2A phosphatase
CC activity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with LMO2, possibly leading to regulate the
CC transcriptional activity of a DNA-binding complex containing LMO2 (By
CC similarity). Interacts with OMP. {ECO:0000250,
CC ECO:0000269|PubMed:12911636, ECO:0000269|PubMed:15198671}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Primarily localized to neuronal cells within
CC several regions of the brain, including the olfactory epithelium, bulb,
CC peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus,
CC median eminence, lateral hypothalamic area, thalamus, hippocampus and
CC cerebellum (at protein level). {ECO:0000269|PubMed:15861462}.
CC -!- SIMILARITY: Belongs to the BEX family. {ECO:0000305}.
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DR EMBL; AF097439; AAD24430.1; -; mRNA.
DR EMBL; AK132005; BAE20934.1; -; mRNA.
DR EMBL; BC027529; AAH27529.1; -; mRNA.
DR RefSeq; NP_033879.1; NM_009749.2.
DR AlphaFoldDB; Q9WTZ8; -.
DR MINT; Q9WTZ8; -.
DR STRING; 10090.ENSMUSP00000043113; -.
DR iPTMnet; Q9WTZ8; -.
DR PhosphoSitePlus; Q9WTZ8; -.
DR MaxQB; Q9WTZ8; -.
DR PaxDb; Q9WTZ8; -.
DR PRIDE; Q9WTZ8; -.
DR ProteomicsDB; 273557; -.
DR DNASU; 12069; -.
DR Ensembl; ENSMUST00000049130; ENSMUSP00000043113; ENSMUSG00000042750.
DR GeneID; 12069; -.
DR KEGG; mmu:12069; -.
DR UCSC; uc009uia.2; mouse.
DR CTD; 84707; -.
DR MGI; MGI:1338017; Bex2.
DR VEuPathDB; HostDB:ENSMUSG00000042750; -.
DR eggNOG; ENOG502RW3Y; Eukaryota.
DR GeneTree; ENSGT00940000153412; -.
DR HOGENOM; CLU_123122_1_0_1; -.
DR InParanoid; Q9WTZ8; -.
DR OMA; PVLQYRW; -.
DR OrthoDB; 1532209at2759; -.
DR PhylomeDB; Q9WTZ8; -.
DR TreeFam; TF337909; -.
DR BioGRID-ORCS; 12069; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q9WTZ8; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9WTZ8; protein.
DR Bgee; ENSMUSG00000042750; Expressed in arcuate nucleus of hypothalamus and 206 other tissues.
DR Genevisible; Q9WTZ8; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005667; C:transcription regulator complex; ISO:MGI.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; ISO:MGI.
DR GO; GO:0051726; P:regulation of cell cycle; ISO:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR007623; BEX.
DR InterPro; IPR021156; TF_A-like/BEX.
DR PANTHER; PTHR19430; PTHR19430; 1.
DR Pfam; PF04538; BEX; 1.
DR PIRSF; PIRSF008633; BEX; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Cell cycle; Cytoplasm; Methylation; Nucleus; Reference proteome.
FT CHAIN 1..129
FT /note="Protein BEX2"
FT /id="PRO_0000229778"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 51
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
SQ SEQUENCE 129 AA; 15452 MW; 2CB3798C8BEC2E89 CRC64;
MESKVEQGVK NLNMENDHQE KEEKEEKPQD ASKRDPIVAL PFEAGDYYVP RGGRRRFRVR
QPIVHYRWDL MHRVGEPQGR MREENVQRFG DDVRQLMEKL RERQLSHSLR AVSTDPPHHD
HHDEFCLMP
