ID   BEX2_RAT                Reviewed;         129 AA.
AC   Q3MKQ1;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protein BEX2;
DE   AltName: Full=Brain-expressed X-linked protein 2 homolog;
GN   Name=Bex2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND MUTAGENESIS OF
RP   ARG-103.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=15958283; DOI=10.1016/j.gene.2005.05.012;
RA   Alvarez E., Zhou W., Witta S.E., Freed C.R.;
RT   "Characterization of the Bex gene family in humans, mice, and rats.";
RL   Gene 357:18-28(2005).
CC   -!- FUNCTION: Regulator of mitochondrial apoptosis and G1 cell cycle.
CC       Regulates the level of PP2A regulatory subunit B and PP2A phosphatase
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LMO2, possibly leading to regulate the
CC       transcriptional activity of a DNA-binding complex containing LMO2.
CC       Interacts with OMP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15958283}. Cytoplasm
CC       {ECO:0000269|PubMed:15958283}.
CC   -!- SIMILARITY: Belongs to the BEX family. {ECO:0000305}.
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DR   EMBL; AY833555; AAX40673.1; -; mRNA.
DR   RefSeq; NP_001070903.1; NM_001077435.1.
DR   AlphaFoldDB; Q3MKQ1; -.
DR   STRING; 10116.ENSRNOP00000041688; -.
DR   PhosphoSitePlus; Q3MKQ1; -.
DR   jPOST; Q3MKQ1; -.
DR   PaxDb; Q3MKQ1; -.
DR   PRIDE; Q3MKQ1; -.
DR   Ensembl; ENSRNOT00000042126; ENSRNOP00000041688; ENSRNOG00000032729.
DR   GeneID; 363498; -.
DR   KEGG; rno:363498; -.
DR   UCSC; RGD:1564466; rat.
DR   CTD; 84707; -.
DR   RGD; 1564466; Bex2.
DR   eggNOG; ENOG502RW3Y; Eukaryota.
DR   GeneTree; ENSGT00940000153412; -.
DR   HOGENOM; CLU_123122_1_0_1; -.
DR   InParanoid; Q3MKQ1; -.
DR   OMA; AKCPGGA; -.
DR   OrthoDB; 1532209at2759; -.
DR   PhylomeDB; Q3MKQ1; -.
DR   TreeFam; TF337909; -.
DR   PRO; PR:Q3MKQ1; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000032729; Expressed in cerebellum and 13 other tissues.
DR   Genevisible; Q3MKQ1; RN.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0051726; P:regulation of cell cycle; ISO:RGD.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR007623; BEX.
DR   InterPro; IPR021156; TF_A-like/BEX.
DR   PANTHER; PTHR19430; PTHR19430; 1.
DR   Pfam; PF04538; BEX; 1.
DR   PIRSF; PIRSF008633; BEX; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Cell cycle; Cytoplasm; Methylation; Nucleus; Reference proteome.
FT   CHAIN           1..129
FT                   /note="Protein BEX2"
FT                   /id="PRO_0000229779"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         51
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WTZ8"
FT   MUTAGEN         103
FT                   /note="R->L: Induces a redistribution from both the nucleus
FT                   and cytoplasm to only the cytoplasm."
FT                   /evidence="ECO:0000269|PubMed:15958283"
SQ   SEQUENCE   129 AA;  15541 MW;  BB8AF95C1058A4A7 CRC64;
     MESKVEQGVK NLNMENDHQE KEEKEEKPQD ANKREPVVAL PFEAGEYYVP RGSRRRFRVR
     QPIAHYRWDL MHRVGEPQGR MREENVQRFG EDMRQLMEKL RERQLSHSLR AVSTDPPHHD
     HHDEFCLMP