ID   BEX3_BOVIN              Reviewed;         112 AA.
AC   Q3ZBJ6;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Protein BEX3 {ECO:0000305};
DE   AltName: Full=Brain-expressed X-linked protein 3 homolog {ECO:0000250|UniProtKB:Q00994};
DE   AltName: Full=Nerve growth factor receptor-associated protein 1;
DE   AltName: Full=p75NTR-associated cell death executor;
GN   Name=BEX3 {ECO:0000250|UniProtKB:Q00994}; Synonyms=NADE, NGFRAP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Kidney;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a signaling adapter molecule involved in p75NTR-
CC       mediated apoptosis induced by NGF. Plays a role in zinc-triggered
CC       neuronal death (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Binds to the DEATH domain of p75NTR/NGFR.
CC       Interacts with 14-3-3 epsilon YWHAE. Interacts with DIABLO/SMAC.
CC       {ECO:0000250|UniProtKB:Q9WTZ9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the
CC       cytoplasm and the nucleus. Associates with replicating mitochondria (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: The nuclear export signal is required for export from the
CC       nucleus and the interactions with itself and p75NTR/NGFR.
CC       {ECO:0000250}.
CC   -!- PTM: Ubiquitinated. Degraded by the proteasome (By similarity).
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Binds transition metals. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BEX family. {ECO:0000305}.
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DR   EMBL; BC103258; AAI03259.1; -; mRNA.
DR   RefSeq; NP_001157249.1; NM_001163777.2.
DR   AlphaFoldDB; Q3ZBJ6; -.
DR   STRING; 9913.ENSBTAP00000007916; -.
DR   PaxDb; Q3ZBJ6; -.
DR   Ensembl; ENSBTAT00000007916; ENSBTAP00000007916; ENSBTAG00000006026.
DR   GeneID; 100034674; -.
DR   KEGG; bta:100034674; -.
DR   CTD; 27018; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006026; -.
DR   VGNC; VGNC:50552; BEX3.
DR   eggNOG; ENOG502TF4N; Eukaryota.
DR   GeneTree; ENSGT00940000153412; -.
DR   HOGENOM; CLU_123122_0_0_1; -.
DR   InParanoid; Q3ZBJ6; -.
DR   OMA; PMQNREE; -.
DR   OrthoDB; 1577482at2759; -.
DR   TreeFam; TF337909; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000006026; Expressed in Ammon's horn and 105 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR007623; BEX.
DR   InterPro; IPR021156; TF_A-like/BEX.
DR   PANTHER; PTHR19430; PTHR19430; 1.
DR   Pfam; PF04538; BEX; 1.
DR   PIRSF; PIRSF008633; BEX; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Cytoplasm; Metal-binding; Nucleus; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..112
FT                   /note="Protein BEX3"
FT                   /id="PRO_0000229780"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..112
FT                   /note="Interaction with 14-3-3 epsilon"
FT                   /evidence="ECO:0000250"
FT   REGION          69..94
FT                   /note="Interaction with p75NTR/NGFR"
FT                   /evidence="ECO:0000250"
FT   MOTIF           78..88
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        23..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   112 AA;  13249 MW;  F8B81AC939E90A7D CRC64;
     MANIHQENEE MEQPVQNGEE DRPLGGGEGH QPERNHRRGQ ARRLAPNFRW VIPNRQVNDG
     MGGEGDDMEI FMEEMREIRR KLRELQLRNC LRILMGELSN HHDHHDEFCL MP