ID   ABDA_TRICA              Reviewed;         343 AA.
AC   Q07961;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Homeobox protein abdominal-A homolog;
GN   Name=ABD-A;
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=Georgia;
RA   Brown S.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-343.
RX   PubMed=7900986; DOI=10.1242/dev.117.1.233;
RA   Stuart J.J., Brown S.J., Beeman R.W., Denell R.E.;
RT   "The Tribolium homeotic gene Abdominal is homologous to abdominal-A of the
RT   Drosophila bithorax complex.";
RL   Development 117:233-243(1993).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Abd-AII;
CC         IsoId=Q07961-1; Sequence=Displayed;
CC       Name=Abd-AI;
CC         IsoId=Q07961-2; Sequence=VSP_002395;
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AF017415; AAB70262.1; -; mRNA.
DR   EMBL; AF017415; AAB70263.1; -; mRNA.
DR   EMBL; AF017414; AAB70261.1; -; Genomic_DNA.
DR   EMBL; AF017414; AAB70260.1; -; Genomic_DNA.
DR   EMBL; X72339; CAA51066.1; -; Genomic_DNA.
DR   RefSeq; NP_001034518.1; NM_001039429.1. [Q07961-1]
DR   RefSeq; XP_015839429.1; XM_015983943.1. [Q07961-1]
DR   AlphaFoldDB; Q07961; -.
DR   SMR; Q07961; -.
DR   STRING; 7070.TC000894-PA; -.
DR   EnsemblMetazoa; TC000894_001; TC000894_001; TC000894. [Q07961-1]
DR   GeneID; 641595; -.
DR   KEGG; tca:641595; -.
DR   CTD; 42037; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   HOGENOM; CLU_750519_0_0_1; -.
DR   OMA; MSHEQHK; -.
DR   PhylomeDB; Q07961; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022132; Abdominal-A.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF12407; Abdominal-A; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus.
FT   CHAIN           1..343
FT                   /note="Homeobox protein abdominal-A homolog"
FT                   /id="PRO_0000200254"
FT   DNA_BIND        216..275
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          29..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..302
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..326
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..59
FT                   /note="Missing (in isoform Abd-AI)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002395"
SQ   SEQUENCE   343 AA;  37772 MW;  D5CE73A71CFECE48 CRC64;
     MSSKFIIDSM LPKYHQQFHH QQLFQSATTE APAAYSSSSP SGSSPQHSSS SASTSPAARM
     YPYVSAAHHH HQAAAAAFGA AASGSMVPSF SSTASSALAA AVDAATDKSC RYTAGLAANV
     TPADSMVNYT LGQHHHNGAA VSAASSVSAA SASMAVAAQF YHQAASAVVD PLNSCSQPAA
     PGGQPIPDIP RYPWMSITDW MSPFDRVVCG PNGCPRRRGR QTYTRFQTLE LEKEFHFNHY
     LTRRRRIEIA HALCLTERQI KIWFQNRRMK LKKELRAVKE INEQARRERE EQERHKQQQQ
     EKQQKIEQQT HSSIHQHHHD PMKMSLDKSG GSDLLKAVSK VPT