BEX3_RAT
ID BEX3_RAT Reviewed; 130 AA.
AC Q6PDU5; Q9JIT2;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein BEX3 {ECO:0000305};
DE AltName: Full=Brain-expressed X-linked protein 3 homolog {ECO:0000312|RGD:3148};
DE Short=rBex3;
DE AltName: Full=Nerve growth factor receptor-associated protein 1;
DE AltName: Full=p75NTR-associated cell death executor;
GN Name=Bex3 {ECO:0000312|RGD:3148}; Synonyms=Nade, Ngfrap1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=Sprague-Dawley;
RX PubMed=10764727; DOI=10.1074/jbc.c000140200;
RA Mukai J., Hachiya T., Shoji-Hoshino S., Kimura M.T., Nadano D., Suvanto P.,
RA Hanaoka T., Li Y., Irie S., Greene L.A., Sato T.-A.;
RT "NADE, a p75NTR-associated cell death executor, is involved in signal
RT transduction mediated by the common neurotrophin receptor p75NTR.";
RL J. Biol. Chem. 275:17566-17570(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, AND
RP DEGRADATION BY THE PROTEASOME.
RC STRAIN=Sprague-Dawley;
RX PubMed=15958283; DOI=10.1016/j.gene.2005.05.012;
RA Alvarez E., Zhou W., Witta S.E., Freed C.R.;
RT "Characterization of the Bex gene family in humans, mice, and rats.";
RL Gene 357:18-28(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION.
RX PubMed=11124986; DOI=10.1523/jneurosci.20-24-09096.2000;
RA Park J.A., Lee J.-Y., Sato T.-A., Koh J.-Y.;
RT "Co-induction of p75NTR and p75NTR-associated death executor in neurons
RT after zinc exposure in cortical culture or transient ischemia in the rat.";
RL J. Neurosci. 20:9096-9103(2000).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=11224788; DOI=10.1097/00005537-200103000-00027;
RA Sano H., Mukai J., Monoo K., Close L.G., Sato T.-A.;
RT "Expression of p75NTR and its associated protein NADE in the rat cochlea.";
RL Laryngoscope 111:535-538(2001).
RN [6]
RP INDUCTION.
RX PubMed=12873743; DOI=10.1016/s0304-3940(03)00656-6;
RA Yi J.-S., Lee S.-K., Sato T.-A., Koh J.-Y.;
RT "Co-induction of p75(NTR) and the associated death executor NADE in
RT degenerating hippocampal neurons after kainate-induced seizures in the
RT rat.";
RL Neurosci. Lett. 347:126-130(2003).
CC -!- FUNCTION: May be a signaling adapter molecule involved in p75NTR-
CC mediated apoptosis induced by NGF. Plays a role in zinc-triggered
CC neuronal death. {ECO:0000269|PubMed:11124986}.
CC -!- SUBUNIT: Self-associates. Binds to the DEATH domain of p75NTR/NGFR.
CC Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC.
CC {ECO:0000250|UniProtKB:Q9WTZ9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
CC {ECO:0000269|PubMed:15958283}. Note=Shuttles between the cytoplasm and
CC the nucleus. Associates with replicating mitochondria (By similarity).
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PDU5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PDU5-2; Sequence=VSP_017745;
CC -!- TISSUE SPECIFICITY: In cochlea, it is expressed in pillar cells from
CC postnatal day 2 to adulthood. {ECO:0000269|PubMed:11224788}.
CC -!- INDUCTION: In neurons degenerating after kainate-induced seizures,
CC likely in a zinc-dependent manner. {ECO:0000269|PubMed:12873743}.
CC -!- DOMAIN: The nuclear export signal is required for export from the
CC nucleus and the interactions with itself and p75NTR/NGFR.
CC {ECO:0000250}.
CC -!- PTM: Ubiquitinated (Probable). Degraded by the proteasome.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: Binds transition metals.
CC -!- SIMILARITY: Belongs to the BEX family. {ECO:0000305}.
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DR EMBL; AF187065; AAF75130.1; -; mRNA.
DR EMBL; AY833556; AAX40674.1; -; mRNA.
DR EMBL; BC058503; AAH58503.1; -; mRNA.
DR RefSeq; NP_445853.1; NM_053401.1. [Q6PDU5-2]
DR RefSeq; XP_006257319.1; XM_006257257.3. [Q6PDU5-1]
DR RefSeq; XP_006257320.1; XM_006257258.3. [Q6PDU5-2]
DR AlphaFoldDB; Q6PDU5; -.
DR BioGRID; 250665; 2.
DR STRING; 10116.ENSRNOP00000042696; -.
DR PaxDb; Q6PDU5; -.
DR Ensembl; ENSRNOT00000045997; ENSRNOP00000042696; ENSRNOG00000028822. [Q6PDU5-1]
DR Ensembl; ENSRNOT00000101625; ENSRNOP00000077160; ENSRNOG00000028822. [Q6PDU5-1]
DR Ensembl; ENSRNOT00000101693; ENSRNOP00000082465; ENSRNOG00000028822. [Q6PDU5-2]
DR GeneID; 117089; -.
DR KEGG; rno:117089; -.
DR UCSC; RGD:3148; rat. [Q6PDU5-1]
DR CTD; 27018; -.
DR RGD; 3148; Bex3.
DR eggNOG; ENOG502TF4N; Eukaryota.
DR GeneTree; ENSGT00940000153412; -.
DR HOGENOM; CLU_123122_0_0_1; -.
DR InParanoid; Q6PDU5; -.
DR OMA; PMQNREE; -.
DR OrthoDB; 1577482at2759; -.
DR PhylomeDB; Q6PDU5; -.
DR TreeFam; TF337909; -.
DR Reactome; R-RNO-205025; NADE modulates death signalling.
DR PRO; PR:Q6PDU5; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000028822; Expressed in ovary and 20 other tissues.
DR ExpressionAtlas; Q6PDU5; baseline and differential.
DR Genevisible; Q6PDU5; RN.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005123; F:death receptor binding; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005163; F:nerve growth factor receptor binding; IDA:RGD.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; ISO:RGD.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR007623; BEX.
DR InterPro; IPR021156; TF_A-like/BEX.
DR PANTHER; PTHR19430; PTHR19430; 1.
DR Pfam; PF04538; BEX; 1.
DR PIRSF; PIRSF008633; BEX; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Apoptosis; Cytoplasm; Metal-binding; Nucleus;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..130
FT /note="Protein BEX3"
FT /id="PRO_0000229782"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..130
FT /note="Interaction with 14-3-3 epsilon"
FT /evidence="ECO:0000250"
FT REGION 87..112
FT /note="Interaction with p75NTR/NGFR"
FT /evidence="ECO:0000250"
FT MOTIF 96..106
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 42..61
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..10
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10764727,
FT ECO:0000303|PubMed:15958283"
FT /id="VSP_017745"
SQ SEQUENCE 130 AA; 15333 MW; 57B8DC9F343E934A CRC64;
MANIHQENEE MEQPLQNGQE DRPVGGGEGH QPAANNNNHN HNHNHNHNHN HNHHRRGQAR
RLAPNFRWAI PNRQMNDGLG GDGDDMEMFM EEMREIRRKL RELQLRNCLR ILMGELSNHH
DHHDEFCLMP
