ID   SDHD_BACSU              Reviewed;         448 AA.
AC   P54555;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Probable D-serine dehydratase;
DE            EC=4.3.1.18;
DE   AltName: Full=D-serine deaminase;
DE            Short=DSD;
GN   Name=dsdA; Synonyms=yqjR; OrderedLocusNames=BSU23770;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 447.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:13977,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:35247; EC=4.3.1.18;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the serine/threonine dehydratase family. DsdA
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D84432; BAA12624.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14309.2; -; Genomic_DNA.
DR   PIR; B69965; B69965.
DR   RefSeq; NP_390258.2; NC_000964.3.
DR   RefSeq; WP_004399082.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P54555; -.
DR   SMR; P54555; -.
DR   STRING; 224308.BSU23770; -.
DR   PaxDb; P54555; -.
DR   PRIDE; P54555; -.
DR   EnsemblBacteria; CAB14309; CAB14309; BSU_23770.
DR   GeneID; 938700; -.
DR   KEGG; bsu:BSU23770; -.
DR   PATRIC; fig|224308.179.peg.2590; -.
DR   eggNOG; COG3048; Bacteria.
DR   InParanoid; P54555; -.
DR   OMA; ESDPNCF; -.
DR   PhylomeDB; P54555; -.
DR   BioCyc; BSUB:BSU23770-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0008721; F:D-serine ammonia-lyase activity; IBA:GO_Central.
DR   GO; GO:0016836; F:hydro-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0036088; P:D-serine catabolic process; IBA:GO_Central.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   HAMAP; MF_01030; D_Ser_dehydrat; 1.
DR   InterPro; IPR011780; D_Ser_am_lyase.
DR   InterPro; IPR001926; PLP-dep.
DR   InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR   InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR   PANTHER; PTHR48078:SF9; PTHR48078:SF9; 1.
DR   Pfam; PF00291; PALP; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
DR   TIGRFAMs; TIGR02035; D_Ser_am_lyase; 1.
DR   PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE   3: Inferred from homology;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..448
FT                   /note="Probable D-serine dehydratase"
FT                   /id="PRO_0000185608"
FT   MOD_RES         117
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        447
FT                   /note="E -> G (in Ref. 1; BAA12624)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   448 AA;  49732 MW;  70D936998992613F CRC64;
     MSVHSEVLHA LLKDPFIQKL IDAEPVFWAN SGKKEGPLPR ADEWATEIAE AEKRMQRFAP
     YIAEVFPETK GAKGIIESPL FEVQHMKGKL EAAYQQPFPG RWLLKCDHEL PISGSIKARG
     GIYEVLKYAE NLALQEGMLQ ETDDYRILQE ERFTGFFSRY SIAVGSTGNL GLSIGIIGAA
     LGFRVTVHMS ADAKQWKKDL LRQKGVTVME YETDYSEAVN EGRRQAEQDP FCYFIDDEHS
     RQLFLGYAVA ASRLKTQLDC MNIKPSLETP LFVYLPCGVG GGPGGVAFGL KLLYGDDVHV
     FFAEPTHSPC MLLGLYSGLH EKISVQDIGL DNQTAADGLA VGRPSGFVGK LIEPLLSGCY
     TVEDNTLYTL LHMLAVSEDK YLEPSALAGM FGPVQLFSTE EGRRYAQKYK MEHAVHVVWG
     TGGSMVPKDE MAAYNRIGAD LLKKRNEK