BEX4_MOUSE
ID BEX4_MOUSE Reviewed; 118 AA.
AC Q9CWT2;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein BEX4 {ECO:0000305};
DE AltName: Full=Brain-expressed X-linked protein 4 {ECO:0000312|MGI:MGI:3606746};
GN Name=Bex4 {ECO:0000303|PubMed:15958283, ECO:0000312|MGI:MGI:3606746};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15958283; DOI=10.1016/j.gene.2005.05.012;
RA Alvarez E., Zhou W., Witta S.E., Freed C.R.;
RT "Characterization of the Bex gene family in humans, mice, and rats.";
RL Gene 357:18-28(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION BY CADMIUM.
RX PubMed=28295929; DOI=10.1002/jbt.21908;
RA Yu W., Yaping L., Mingjun W., Jie H., Xiaogang L., Gang L.;
RT "BEX4 upregulation alters Sertoli cell growth properties and protein
RT expression profiles: An explanation for cadmium-induced testicular Sertoli
RT cell injury.";
RL J. Biochem. Mol. Toxicol. 31:0-0(2017).
RN [4]
RP INDUCTION BY CURCUMIN.
RX PubMed=28145533; DOI=10.1038/srep41420;
RA Sidhar H., Giri R.K.;
RT "Induction of Bex genes by curcumin is associated with apoptosis and
RT activation of p53 in N2a neuroblastoma cells.";
RL Sci. Rep. 7:41420-41420(2017).
CC -!- FUNCTION: May play a role in microtubule deacetylation by negatively
CC regulating the SIRT2 deacetylase activity toward alpha-tubulin and
CC thereby participate in the control of cell cycle progression and
CC genomic stability. {ECO:0000250|UniProtKB:Q9NWD9}.
CC -!- SUBUNIT: Interacts with alpha-tubulin. Interacts with SIRT2.
CC {ECO:0000250|UniProtKB:Q9NWD9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000250|UniProtKB:Q9NWD9}. Nucleus {ECO:0000250|UniProtKB:Q9NWD9}.
CC Cytoplasm {ECO:0000269|PubMed:28295929}. Note=Also localizes to
CC microtubules. {ECO:0000250|UniProtKB:Q9NWD9}.
CC -!- TISSUE SPECIFICITY: Expressed in both Sertoli and germ cells as well as
CC interstitial area of the testis (at protein level).
CC {ECO:0000269|PubMed:28295929}.
CC -!- INDUCTION: Up-regulated by cadmium in testis (at protein level)
CC (PubMed:28295929). Up-regulated by curcumin (PubMed:28145533).
CC {ECO:0000269|PubMed:28145533, ECO:0000269|PubMed:28295929}.
CC -!- PTM: Ubiquitinated and degraded by the proteasome.
CC {ECO:0000250|UniProtKB:Q3MKP9}.
CC -!- SIMILARITY: Belongs to the BEX family. {ECO:0000305}.
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DR EMBL; AY833558; AAX40676.1; -; mRNA.
DR EMBL; AK010400; BAB26911.1; -; mRNA.
DR CCDS; CCDS30414.1; -.
DR RefSeq; NP_997622.1; NM_212457.2.
DR AlphaFoldDB; Q9CWT2; -.
DR SMR; Q9CWT2; -.
DR STRING; 10090.ENSMUSP00000112226; -.
DR iPTMnet; Q9CWT2; -.
DR PhosphoSitePlus; Q9CWT2; -.
DR MaxQB; Q9CWT2; -.
DR PaxDb; Q9CWT2; -.
DR PRIDE; Q9CWT2; -.
DR ProteomicsDB; 273672; -.
DR Ensembl; ENSMUST00000116527; ENSMUSP00000112226; ENSMUSG00000047844.
DR GeneID; 406217; -.
DR KEGG; mmu:406217; -.
DR UCSC; uc009uic.2; mouse.
DR CTD; 56271; -.
DR MGI; MGI:3606746; Bex4.
DR VEuPathDB; HostDB:ENSMUSG00000047844; -.
DR eggNOG; ENOG502TDUR; Eukaryota.
DR GeneTree; ENSGT00940000162932; -.
DR HOGENOM; CLU_123122_0_0_1; -.
DR InParanoid; Q9CWT2; -.
DR OMA; NIDHNEM; -.
DR OrthoDB; 1525516at2759; -.
DR PhylomeDB; Q9CWT2; -.
DR TreeFam; TF337909; -.
DR BioGRID-ORCS; 406217; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Bex4; mouse.
DR PRO; PR:Q9CWT2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9CWT2; protein.
DR Bgee; ENSMUSG00000047844; Expressed in yolk sac and 70 other tissues.
DR ExpressionAtlas; Q9CWT2; baseline and differential.
DR Genevisible; Q9CWT2; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005874; C:microtubule; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR GO; GO:0043014; F:alpha-tubulin binding; ISS:UniProtKB.
DR GO; GO:0042826; F:histone deacetylase binding; ISO:MGI.
DR GO; GO:0007059; P:chromosome segregation; ISS:UniProtKB.
DR GO; GO:1904428; P:negative regulation of tubulin deacetylation; ISS:UniProtKB.
DR GO; GO:0030334; P:regulation of cell migration; ISO:MGI.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:UniProtKB.
DR InterPro; IPR007623; BEX.
DR InterPro; IPR021156; TF_A-like/BEX.
DR PANTHER; PTHR13987; PTHR13987; 1.
DR Pfam; PF04538; BEX; 1.
DR PIRSF; PIRSF008633; BEX; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Ubl conjugation.
FT CHAIN 1..118
FT /note="Protein BEX4"
FT /id="PRO_0000229784"
FT REGION 14..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 30..118
FT /note="Interaction with alpha-tubulin"
FT /evidence="ECO:0000250|UniProtKB:Q9NWD9"
FT REGION 30..88
FT /note="Interaction with SIRT2"
FT /evidence="ECO:0000250|UniProtKB:Q9NWD9"
FT COMPBIAS 14..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 118 AA; 13820 MW; 80557188C3419CD7 CRC64;
MASKFKQVIL DLTVEKDKKD KKGGKASKQS EEEPHHLEEV ENKKPGGNVR RKVRRLVPNF
LWAIPNRHVD RNEGGEDVGR FVVQGTEVKR KTTEQQVRPY RRFRTPEPDN HYDFCLIP
