ID   SDHD_OENOB              Reviewed;         433 AA.
AC   Q04G28;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Probable D-serine dehydratase {ECO:0000255|HAMAP-Rule:MF_01030};
DE            EC=4.3.1.18 {ECO:0000255|HAMAP-Rule:MF_01030};
DE   AltName: Full=D-serine deaminase {ECO:0000255|HAMAP-Rule:MF_01030};
DE            Short=DSD {ECO:0000255|HAMAP-Rule:MF_01030};
GN   Name=dsdA {ECO:0000255|HAMAP-Rule:MF_01030}; OrderedLocusNames=OEOE_0657;
OS   Oenococcus oeni (strain ATCC BAA-331 / PSU-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Oenococcus.
OX   NCBI_TaxID=203123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-331 / PSU-1;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:13977,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:35247; EC=4.3.1.18;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01030};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01030};
CC   -!- SIMILARITY: Belongs to the serine/threonine dehydratase family. DsdA
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01030}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABJ56594.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000411; ABJ56594.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041346443.1; NC_008528.1.
DR   AlphaFoldDB; Q04G28; -.
DR   SMR; Q04G28; -.
DR   STRING; 203123.OEOE_0657; -.
DR   DNASU; 4416798; -.
DR   EnsemblBacteria; ABJ56594; ABJ56594; OEOE_0657.
DR   KEGG; ooe:OEOE_0657; -.
DR   PATRIC; fig|203123.7.peg.665; -.
DR   eggNOG; COG3048; Bacteria.
DR   HOGENOM; CLU_035707_0_0_9; -.
DR   OrthoDB; 912282at2; -.
DR   Proteomes; UP000000774; Chromosome.
DR   GO; GO:0008721; F:D-serine ammonia-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016836; F:hydro-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0046416; P:D-amino acid metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   HAMAP; MF_01030; D_Ser_dehydrat; 1.
DR   InterPro; IPR011780; D_Ser_am_lyase.
DR   InterPro; IPR001926; PLP-dep.
DR   InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR   InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR   PANTHER; PTHR48078:SF9; PTHR48078:SF9; 1.
DR   Pfam; PF00291; PALP; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
DR   TIGRFAMs; TIGR02035; D_Ser_am_lyase; 1.
DR   PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE   3: Inferred from homology;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..433
FT                   /note="Probable D-serine dehydratase"
FT                   /id="PRO_0000291734"
FT   MOD_RES         110
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01030"
SQ   SEQUENCE   433 AA;  48272 MW;  C36355D401651420 CRC64;
     MTETLLKKKL NLNDQFLLNL KNYQEIFWKN PNYGDELPDL DVNRETIFQA NRRLERFAPY
     LESVFSDTKR SKGIIESPIQ RMDSIKDLLS VKGSLLIKRD DLMPVSGSIK SRGGIYEVLC
     FAEKIAIENG FDLKKDNYQD LRKDKYRKLF NQWRIEVAST GNLGLSVGLM ASTLGFKARI
     HMSHDATDWK INKLLQNGVE VKIYDDNFSN AVAAARVSSQ RDPYSYFIDD EGSKLLFAGY
     ATAGERVKKQ LSKMQIEVSK EHPLVVYLPA GVGGSPSGVA FGLKLQFADA VIPIFVEPTH
     MPSVLLGMAS GLNHDISVYD IGIDGKTAAD GLAVGRPSMI AGKYMKDKLF GIATVSDSDM
     FAYQGMLKKL ENIEVEPSAA VGIRGLIQSK EISEIPDSAT HMVWATGGSM VPKNTMHKYE
     DKAVRIFNTW KSE